NANOSOLUTIONS
Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment
| Coordinatore | TYOETERVEYSLAITOS
Organization address
address: Topeliuksenkatu 41 a A contact info |
| Nazionalità Coordinatore | Finland [FI] |
| Sito del progetto | http://nanosolutionsfp7.com |
| Totale costo | 13˙765˙733 € |
| EC contributo | 10˙000˙000 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2012-LARGE-6 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-04-01 - 2017-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
TYOETERVEYSLAITOS
Organization address
address: Topeliuksenkatu 41 a A contact info |
FI (HELSINKI) | coordinator | 1˙913˙591.59 |
| 2 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 1˙394˙999.60 |
| 3 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Organization address
address: BELFIELD contact info |
IE (DUBLIN) | participant | 580˙051.00 |
| 4 |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address
address: GESCHWISTER SCHOLL PLATZ 1 contact info |
DE (MUENCHEN) | participant | 464˙100.00 |
| 5 |
UNIVERSITY OF PLYMOUTH
Organization address
address: DRAKE CIRCUS contact info |
UK (PLYMOUTH) | participant | 414˙064.80 |
| 6 |
INSIGHT PUBLISHERS LIMITED
Organization address
address: KING SQUARE 12-13 contact info |
UK (BRISTOL) | participant | 399˙240.00 |
| 7 |
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES
Organization address
address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182 contact info |
ES (SAN SEBASTIAN) | participant | 365˙000.00 |
| 8 |
MISVIK BIOLOGY OY
Organization address
address: ITAINEN PITKAKATU 4 B contact info |
FI (TURKU) | participant | 350˙562.98 |
| 9 |
INSTITUTE OF OCCUPATIONAL MEDICINE
Organization address
address: Research Avenue North, Riccarton 45 contact info |
UK (EDINBURGH) | participant | 339˙686.29 |
| 10 |
HERIOT-WATT UNIVERSITY
Organization address
address: Riccarton contact info |
UK (EDINBURGH) | participant | 299˙999.60 |
| 11 |
EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT
Organization address
address: Ueberlandstrasse 129 contact info |
CH (DUEBENDORF) | participant | 290˙000.00 |
| 12 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | participant | 289˙999.75 |
| 13 |
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Organization address
address: CARRER DE LA INNOVACIO 2 contact info |
ES (TERRASSA) | participant | 274˙152.00 |
| 14 |
UNIVERSITAET LEIPZIG
Organization address
address: RITTERSTRASSE 26 contact info |
DE (LEIPZIG) | participant | 250˙000.40 |
| 15 |
UNIVERSITE DE BORDEAUX
Organization address
address: PLACE PEY BERLAND 35 contact info |
FR (BORDEAUX) | participant | 250˙000.40 |
| 16 |
TURUN YLIOPISTO
Organization address
address: YLIOPISTONMAKI contact info |
FI (TURUN YLIOPISTO) | participant | 249˙999.00 |
| 17 |
FONDAZIONE TELETHON
Organization address
address: VIA VARESE 16/B contact info |
IT (ROMA) | participant | 249˙996.80 |
| 18 |
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Organization address
address: Schoemakerstraat 97 contact info |
NL (DEN HAAG) | participant | 244˙894.75 |
| 19 |
THE UNIVERSITY OF MANCHESTER
Organization address
address: OXFORD ROAD contact info |
UK (MANCHESTER) | participant | 244˙566.12 |
| 20 |
BIOBYTE SOLUTIONS GMBH
Organization address
address: Bothestrasse 142 contact info |
DE (Heidelberg) | participant | 150˙000.00 |
| 21 |
BIOTESYS GMBH
Organization address
address: SCHELZTORSTRASSE 54-56 contact info |
DE (ESSLINGEN) | participant | 150˙000.00 |
| 22 |
PLASMACHEM PRODUKTIONS- UND HANDEL GMBH
Organization address
address: RUDOWER CHAUSSEE 29 contact info |
DE (BERLIN) | participant | 149˙996.00 |
| 23 |
INKOA SISTEMAS SL
Organization address
address: "CALLE RIBERA DE AXPE 11, EDIFICIO D1" contact info |
ES (ERANDIO) | participant | 126˙240.00 |
| 24 |
Nome Ente NON disponibile
Organization address
address: Campus Universitario Darcy Ribeiro contact info |
BR (Brasilia) | participant | 100˙000.00 |
| 25 |
Zhejiang University
Organization address
address: ZHE DA ROAD 38 contact info |
CN (HANGZHOU) | participant | 100˙000.00 |
| 26 |
NATIONAL HEALTH LABORATORY SERVICES
Organization address
address: MODDERFONTEIN ROAD 1 GAUTENG contact info |
ZA (SANDRINGHAM) | participant | 80˙000.00 |
| 27 |
NOORDWES-UNIVERSITEIT
Organization address
address: HOFFMAN STREET 11 contact info |
ZA (POTCHEFSTROOM) | participant | 80˙000.00 |
| 28 |
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Organization address
address: TEKNIIKANTIE 4 A contact info |
FI (ESPOO) | participant | 50˙986.14 |
| 29 |
UNIVERSITA DEGLI STUDI DI SALERNO
Organization address
address: VIA GIOVANNI PAOLO II 132 contact info |
IT (FISCIANO (SA)) | participant | 50˙000.00 |
| 30 |
NANOLOGICA AB
Organization address
city: Stockholm contact info |
SE (Stockholm) | participant | 20˙000.40 |
| 31 |
POLIMEROS Y SISTEMAS DE APLICACION TECNICA SL
Organization address
address: "CALLE CAPCIR 12, POL IND PLACA DE LA BRUGUERA" contact info |
ES (CASTELLAR DEL VALLES) | participant | 19˙880.00 |
| 32 |
POLYMER FACTORY SWEDEN AB
Organization address
address: KRISTINEDALSVAGEN 48 contact info |
SE (NACKA) | participant | 19˙785.00 |
| 33 |
NANOCYL SA
Organization address
address: RUE DE L'ESSOR 4 contact info |
BE (SAMBREVILLE) | participant | 19˙040.00 |
| 34 |
SOLVAY SA
Organization address
address: RUE DE RANSBEEK 310 contact info |
BE (BRUXELLES) | participant | 13˙733.50 |
| 35 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | participant | 5˙433.88 |
| 36 |
LEIDOS BIOMEDICAL RESEARCH INC
Organization address
address: BOYLES STREET 1050 contact info |
US (FREDERICK MD) | participant | 0.00 |
| 37 |
NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH
Organization address
address: WILLOWDALE ROAD MS L 2015 contact info |
US (MORGANTOWN) | participant | 0.00 |
| 38 |
UNIVERSITE BORDEAUX I
Organization address
address: 351 Cours de la Liberation contact info |
FR (TALENCE) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced alterations in gene expression and translation, but may involve also epigenetic transformation of genetic functions. We believe that it will be possible to create a set of biomarkers of ENM toxicity that are relevant in assessing and predicting the safety and toxicity of ENM across species. The ENM-organism interaction is complex and depends, not simply on the composition of ENM core, but particularly on its physico-chemical properties. In fact, important physico-chemical properties are largely governed by their surface properties. All of these factors determine the binding of different biomolecules on the surface of the ENM, the formation of a corona around the ENM core. Thus, any positive or negative biological effect of ENM in organisms may be dynamically modulated by the bio-molecule corona associated with or substituted into the ENM surface rather than the ENM on its own. The bio-molecule corona of seemingly identical ENM cores may undergo dynamic changes during their passage through different biological compartments; in other words, their biological effects are governed by this complex surface chemistry. We propose that understanding the fundamental characteristics of ENM underpinning their biological effects will provide a sound foundation with which to classify ENM according to their safety. Therefore, the overarching objective of this research is to provide a means to develop a safety classification of ENM based on an understanding of their interactions with living organisms at the molecular, cellular, and organism levels based on their material characteristics.'
Introduzione (Teaser)
Engineered nanomaterials (ENMs) are now ubiquitous, but safety studies have lagged behind technological developments. EU-funded research will establish an ENM safety classifier akin to material safety data sheets to ensure safety for humans and the environment.
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