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NANOFOL

Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases

Coordinatore	UNIVERSIDADE DO MINHO Organization address address: Largo do Paco city: BRAGA postcode: 4704553 contact info Titolo: Prof. Nome: Vasco Manuel Cognome: Pinto Texeira Email: send email Telefono: +35 1253 601118 Fax: +351 253601059
Nazionalità Coordinatore	Portugal [PT]
Sito del progetto	http://www.nanofol.eu/
Totale costo	6˙635˙409 €
EC contributo	5˙149˙874 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2008-LARGE-2
Funding Scheme	CP-IP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-12-01 - 2013-11-30

Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSIDADE DO MINHO Organization address address: Largo do Paco city: BRAGA postcode: 4704553 contact info Titolo: Prof. Nome: Vasco Manuel Cognome: Pinto Texeira Email: send email Telefono: +35 1253 601118 Fax: +351 253601059	PT (BRAGA)	coordinator	1˙054˙530.00
2	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mrs. Nome: Tiphaine Cognome: Guida Email: send email Telefono: +33 1 40784913 Fax: +33 1 40784998	FR (PARIS)	participant	522˙780.00
3	INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS Organization address address: Parc Technologique Alata city: VERNEUIL EN HALATTE postcode: 60550 contact info Titolo: Ms. Nome: Lydia Cognome: Boutigny Email: send email Telefono: +33 3 44 55 61 20 Fax: +33 3 44 55 61 10	FR (VERNEUIL EN HALATTE)	participant	468˙319.00
4	NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO Organization address address: Schoemakerstraat 97 city: DEN HAAG postcode: 2600 JA contact info Titolo: Dr. Nome: Herman Cognome: Lenting Email: send email Telefono: +31 88 8665486 Fax: +31 40 2650850	NL (DEN HAAG)	participant	453˙858.53
5	MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Hannes Cognome: Stockinger Email: send email Telefono: +43 1 40160 33001 Fax: +43 1 40160 933002	AT (WIEN)	participant	452˙432.56
6	EXBIO PRAHA AS Organization address address: Nad Safinou II 341 city: VESTEC postcode: 25242 contact info Nome: Stanislav Cognome: Lancouch Email: send email Telefono: 420261000000 Fax: 420261000000	CZ (VESTEC)	participant	418˙175.60
7	SYNOVO GMBH Organization address address: Paul Ehrlich Str 15 city: TUEBINGEN postcode: 72076 contact info Titolo: Dr. Nome: Michael Cognome: Burnet Email: send email Telefono: +49 7071 600543 Fax: +49 7071 964326	DE (TUEBINGEN)	participant	368˙373.90
8	INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR - IBMC Organization address address: RUA DO CAMPO ALEGRE 823 city: PORTO postcode: 4150 180 contact info Titolo: Dr. Nome: Claudia Cognome: Ferreira Email: send email Telefono: +351 226074900 Fax: +351 226068062	PT (PORTO)	participant	314˙437.56
9	TECHNISCHE UNIVERSITAET GRAZ Organization address address: Rechbauerstrasse 12 city: GRAZ postcode: 8010 contact info Titolo: Prof. Nome: Georg Cognome: Guebitz Email: send email Telefono: +43 3168738312 Fax: +43 3168738815	AT (GRAZ)	participant	304˙036.84
10	UNIVERSITATEA AUREL VLAICU DIN ARAD Organization address address: BULEVARD REVOLUTIEI 77 city: Arad postcode: 310130 contact info Titolo: Prof. Nome: Ramona Cognome: Lile Email: send email Telefono: 40721930210	RO (Arad)	participant	285˙175.25
11	ALMA CONSULTING GROUP SAS Organization address address: Domaine des Bois d'Houlbec city: HOULBEC COCHEREL postcode: 27120 contact info Titolo: Ms. Nome: Maud Cognome: Bossard Email: send email Telefono: 33141494100 Fax: 33141494101	FR (HOULBEC COCHEREL)	participant	213˙007.00
12	UNIVERSITAET FUER BODENKULTUR WIEN Organization address address: Gregor Mendel Strasse 33 city: WIEN postcode: 1180 contact info Titolo: Prof. Nome: Georg Cognome: Guebitz Email: send email Telefono: +43 664 572 2600	AT (WIEN)	participant	147˙407.69
13	SUAN FARMA S.A. Organization address address: Einstein 8 city: Alcobendas postcode: 28108 contact info Titolo: Mr. Nome: Ion Cognome: Arocena Velez Email: send email Telefono: +34 915713598 Fax: +34 915671557	ES (Alcobendas)	participant	125˙572.55
14	"Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda." Organization address address: "Av. da Republica, Quinta do Marques, Estacao Agronomica Nacional IBET/ITQB, Lab.7.14" city: Oeiras postcode: 2780-157 contact info Email: send email Telefono: +35 1 21 4469738	PT (Oeiras)	participant	21˙767.53

Mappa

Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

proof activated rheumatoid bystander nanobiodevices arthritis inflammatory chronic affecting nanofol inflammation nanodevice efficacy animal macrophages vitro risk folate diseases fbn strategy vivo cells molecules

Obiettivo del progetto (Objective)

'NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.'

Introduzione (Teaser)

Chronic inflammatory diseases like rheumatoid arthritis (RA) affect over 80 million people worldwide. Anti-arthritis drugs in current use have limited efficacy and are associated with high costs, allergic reactions and potentially lethal side-effects.