NANOGNOSTICS

Quantum Dot-Based Highly Sensitive Immunoassays for Multiplexed Diagnostics of Alzheimer's Disease

Coordinatore	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V    more  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Mr. Nome: Walter Cognome: Krause Email: send email Telefono: +49 89 12052713 Fax: +49 89 12057534
Nazionalità Coordinatore	Germany [DE]
Sito del progetto	http://www.nanognostics.org/
Totale costo	5˙281˙158 €
EC contributo	4˙037˙064 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-10-01   -   2013-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Mr. Nome: Walter Cognome: Krause Email: send email Telefono: +49 89 12052713 Fax: +49 89 12057534	DE (MUENCHEN)	coordinator	448˙725.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Mr. Nome: Denis Cognome: Fix Email: send email Telefono: +33 3 88 10 67 19 Fax: +33 3 88 10 86 08	FR (PARIS)	participant	578˙800.00
3	EDINBURGH INSTRUMENTS LTD  Organization address address: Bain Square 2 city: LIVINGSTON postcode: EH54 7DQ contact info Titolo: Mr. Nome: David Cognome: Mccarlie Email: send email Telefono: 441506000000 Fax: 441506000000	UK (LIVINGSTON)	participant	539˙400.00
4	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Ms. Nome: Jane Cognome: Turner Email: send email Telefono: 97226586676 Fax: 97225613205	IL (JERUSALEM)	participant	515˙100.00
5	CHARITE - UNIVERSITAETSMEDIZIN BERLIN  Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 contact info Titolo: Ms. Nome: Eveline Cognome: Fräßdorf Email: send email Telefono: +49 30 450 57 60 24 Fax: +49 30 450 57 69 54	DE (BERLIN)	participant	488˙700.00
6	PHILIPPS UNIVERSITAET MARBURG  Organization address address: Biegenstrasse 10 city: MARBURG postcode: 35032 contact info Titolo: Prof. Nome: Wolfgang Cognome: Parak Email: send email Telefono: 4964210000000 Fax: 4964210000000	DE (MARBURG)	participant	453˙500.00
7	TURUN YLIOPISTO  Organization address address: YLIOPISTONMAKI city: TURUN YLIOPISTO postcode: 20014 contact info Titolo: Prof. Nome: Pekka Cognome: Hänninen Email: send email Telefono: 358401000000 Fax: 35823337060	FI (TURUN YLIOPISTO)	participant	373˙599.80
8	UNIVERSITAET POTSDAM  Organization address address: AM NEUEN PALAIS 10 city: POTSDAM postcode: 14469 contact info Titolo: Dr. Nome: Regina Cognome: Gerber Email: send email Telefono: +49 331 9771080 Fax: +49 331 9771298	DE (POTSDAM)	participant	364˙800.00
9	UNIVERSITE PARIS-SUD  Organization address address: RUE GEORGES CLEMENCEAU 15 city: ORSAY postcode: 91405 contact info Titolo: Mr. Nome: Nicolas Cognome: Lecompte Email: send email Telefono: +33 1 69155589 Fax: +33 1 69155599	FR (ORSAY)	participant	274˙439.20
10	Arctic Photonics Oy  Organization address address: TILLINMAANPUISTO 3A city: ESPOO postcode: 2330 contact info Titolo: Dr. Nome: Scott Cognome: Buchter Email: send email Telefono: 358443000000 Fax: 358425000000	FI (ESPOO)	participant	0.00

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 Obiettivo del progetto (Objective)

'6.1 million people currently live with a form of dementia in the European Union with an addition of 1.4 million new cases every year. Combination of psychological testing, brain-imaging and exclusion of other neurological disorders makes the diagnosis of Alzheimer’s disease complicated and time consuming (taking up to 20 months). A rapid, sensitive and specific immunoassay for protein markers inside blood would largely improve early diagnosis and lead to a better treatment of dementia. Homogeneous assays based on FRET from one dye labeled specific antibody (AB1) to another (AB2) within an “AB1-biomarker-AB2” immune complex are an ideal basis to meet these diagnostic requirements. As the detection of several protein markers is obligatory for a highly sensitive and specific diagnosis an optical multiplexing approach with dyes of different colors is a smart solution. Semiconductor quantum dots (QDs) are the ideal candidates due to their size-dependent absorption and emission wavelengths. Moreover, they possess unique photophysical properties that overcome conventional fluorescence dyes. In combination with lanthanide complexes (LCs), that display long luminescence lifetimes and well separated emission bands, QDs render a powerful multiplexing tool for highly sensitive diagnostics even for large immune complexes. FRET applications using QDs are to date restricted to academic research and a profound understanding of QD-based FRET is not available. For a comprehensive analysis the use of LCs is mandatory, because they are the only known donors for efficient FRET to QD acceptors. NANOGNOSTICS strives for a profound understanding of QD-based FRET, the synthetic creation of highly efficient QD immune sensors for detection of several Alzheimer-specific protein markers and the development of a modular high-throughput-screening immuno analyzer for the integration of QD-based multiplexing immunoassays into early diagnosis for improved patient outcome in dementia therapy.'

Introduzione (Teaser)

Millions of people worldwide are living with some kind of dementia. Tools offering prompt and accurate disease diagnosis could significantly postpone disease progression or even treat major symptoms.