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INMARE

Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea

Total Cost €

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EC-Contrib. €

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Partnership

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 INMARE project word cloud

Explore the words cloud of the INMARE project. It provides you a very rough idea of what is the project "INMARE" about.

core    market    bioanalytical    hot    proportion    ip    enzyme    expertise    action    collaborative    pipelines    streamlining    discover    bioactive    multidisciplinary    biopolymers    track    screening    industry    discovery    chemicals    construction    clean    cheaper    facilities    innovation    biodiversity    record    identification    bioprocess    structural    biocatalysts    stands    platforms    bioactives    companies    experts    nanoparticle    biobased    allrounders    innovative    prioritize    committed    scientific    edge    fine    cutting    spots    compound    metagenomic    emphasis    biocatalysis    annotation    crystallization    enzymes    biocatalytic    technologies    prototypes    integrating    functional    collections    leaders    agriculture    inmare    expression    safer    libraries    academic    environmental    public    engineering    impressive    establishing    marine    pharmaceuticals    streamline    quality    drugs    unify    biotechnology    assays    bioinformatics    designed    industrial    protein    shortening    sea    diversity    sequence   

Project "INMARE" data sheet

The following table provides information about the project.

Coordinator
BANGOR UNIVERSITY 

Organization address
address: COLLEGE ROAD
city: BANGOR
postcode: LL57 2DG
website: http://www.bangor.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.inmare-h2020.eu
 Total cost 7˙396˙689 €
 EC max contribution 5˙999˙557 € (81%)
 Programme 1. H2020-EU.3.5. (SOCIETAL CHALLENGES - Climate action, Environment, Resource Efficiency and Raw Materials)
2. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
 Code Call H2020-BG-2014-2
 Funding Scheme IA
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BANGOR UNIVERSITY UK (BANGOR) coordinator 733˙411.00
2    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 630˙000.00
3    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 500˙001.00
4    HEINRICH-HEINE-UNIVERSITAET DUESSELDORF DE (DUSSELDORF) participant 345˙000.00
5    UNIVERSITAET HAMBURG DE (HAMBURG) participant 345˙000.00
6    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) participant 330˙000.00
7    NOVOZYMES A/S DK (BAGSVAERD) participant 329˙000.00
8    ASSOCIACAO DO INSTITUTO SUPERIOR TECNICO PARA A INVESTIGACAO E DESENVOLVIMENTO PT (LISBOA) participant 309˙663.00
9    VILNIAUS UNIVERSITETAS LT (VILNIUS) participant 299˙950.00
10    JACOBS UNIVERSITY BREMEN GGMBH DE (BREMEN) participant 283˙968.00
11    POLYTECHNEIO KRITIS EL (CHANIA) participant 250˙000.00
12    PHARMAMAR, S.A. ES (COLMENAR VIEJO (MADRID)) participant 249˙459.00
13    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) participant 227˙150.00
14    UNIVERSITETET I BERGEN NO (BERGEN) participant 220˙000.00
15    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 184˙981.00
16    LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE UK (LONDON) participant 159˙998.00
17    EVOXX TECHNOLOGIES GMBH DE (MONHEIM) participant 151˙637.00
18    NORCE NORWEGIAN RESEARCH CENTRE AS NO (BERGEN) participant 120˙630.00
19    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 115˙000.00
20    SEASCAPE BELGIUM BE (BRUSSEL) participant 79˙231.00
21    SEASCAPE CONSULTANTS LTD UK (ROMSEY HAMPSHIRE) participant 75˙473.00
22    CLUSTER INDUSTRIELLE BIOTECHNOLOGIE 2021 E.V. DE (Düsseldorf) participant 60˙000.00
23    BAYER TECHNOLOGY SERVICES GMBH DE (LEVERKUSEN) participant 0.00
24    FACHHOCHSCHULE NORDWESTSCHWEIZ CH (WINDISCH) participant 0.00
25    INOFEA AG CH (MUTTENZ) participant 0.00
26    THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO CA (TORONTO) participant 0.00
27    UNI RESEARCH AS NO (BERGEN) participant 0.00

Map

 Project objective

INMARE stands for “Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea”. It is a collaborative Innovation Action to streamline the pathways of discovery and industrial applications of new marine enzymes and bioactives for targeted production of fine chemicals, drugs and in environmental clean-up applications. The INMARE consortium will unify the multidisciplinary expertise and facilities of academic and industry partners. This will include integrating the following core activities: advanced technologies to access and sample unique marine biodiversity hot-spots; state-of-the art technologies for construction of metagenomic libraries; innovative enzyme screening assays and platforms; cutting-edge sequence annotation pipelines and bioinformatics resources; high-end activity screening technology; bioanalytical and bioprocess engineering facilities and expertise, nanoparticle-biocatalysts; high-quality protein crystallization and structural analysis facilities and experts in IP management for biotechnology. The companies involved in the project are market leaders in enzyme production and biocatalysis processes designed to efficiently deliver safer (pharmaceuticals) cheaper (agriculture) and biobased (biopolymers) products. They also have impressive track record in environmental clean-up technologies and are committed to promoting public understanding, awareness and dissemination of scientific research. The main emphasis will be focused on streamlining and shortening the pipelines for enzyme and ‘bioactive compound’ discovery towards industrial applications through the establishing of marine enzyme collections with a high proportion of enzymes-“allrounders”. The project will also prioritize the identification of novel lead products and the delivery of improved prototypes for new biocatalytic processes.

 Deliverables

List of deliverables.
D8-15 Two articles on main highlights of the INMARE project in a non-scientific jornal Other 2020-01-28 10:07:37
D8.7 Report on INMARE Bioinformatics training Workshop Other 2020-01-28 10:07:37
D8.10 At least two peer-reviewed papers in legal or inter-disciplinary journals on IP issues Other 2020-01-28 10:07:37
D8.11 At least two patents filed Websites, patent fillings, videos etc. 2020-01-28 10:07:37
D8.14 Two INMARE Science Policy Briefs for management-level personnel and decision makers/advisors with a focus on the research efforts of INMARE Documents, reports 2020-01-28 10:07:36
D8.6 Two articles on main highlights of the INMARE project in a non-scientific journal Other 2020-01-28 10:07:36
D8.5 Report on INMARE Workshop on metagenomics and bioprospecting Other 2020-01-28 10:07:36
D8.9 INMARE Project Leaflet with summary information and noteworthy outputs for wide distribution Websites, patent fillings, videos etc. 2020-01-28 10:07:37
D8.1 Communication and Dissemination Strategy Documents, reports 2020-01-28 10:07:35
D8.2 INMARE Project Website published online Websites, patent fillings, videos etc. 2020-01-28 10:07:35
D8.3 INMARE Project Brochure with general information for wide distribution Documents, reports 2020-01-28 10:07:35
D8.4 Two INMARE Science Policy Briefs for management-level personnel and decision makers/advisors with a focus on the research efforts of INMARE Documents, reports 2020-01-28 10:07:35
D8.8 Report on the inter-disciplinary symposium on ‘Marine Biodiversity: Ownership, Sharing and intellectual Property Protection’ Other 2020-01-28 10:07:37

Take a look to the deliverables list in detail:  detailed list of INMARE deliverables.

 Publications

year authors and title journal last update
List of publications.
2016 Michail M. Yakimov, Francesca Crisafi, Enzo Messina, Francesco Smedile, Anna Lopatina, Renata Denaro, Dietmar H. Pieper, Peter N. Golyshin, Laura Giuliano
Analysis of defence systems and a conjugative IncP-1 plasmid in the marine polyaromatic hydrocarbons-degrading bacterium Cycloclasticus sp. 78-ME
published pages: 508-519, ISSN: 1758-2229, DOI: 10.1111/1758-2229.12424
Environmental Microbiology Reports 8/4 2020-01-28
2015 Negar Moridi, Philippe F.-X. Corvini, Patrick Shahgaldian
Reversible Supramolecular Surface Attachment of Enzyme-Polymer Conjugates for the Design of Biocatalytic Filtration Membranes
published pages: 14800-14804, ISSN: 1433-7851, DOI: 10.1002/anie.201507020
Angewandte Chemie International Edition 54/49 2020-01-28
2016 F. Jerry Reen, John P. Phelan, Lorna Gallagher, David F. Woods, Rachel M. Shanahan, Rafael Cano, Eoin Ó Muimhneacháin, Gerard P. McGlacken, Fergal O\'Gara
Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation
published pages: 5894-5905, ISSN: 0066-4804, DOI: 10.1128/AAC.00190-16
Antimicrobial Agents and Chemotherapy 60/10 2020-01-28
2016 Dulantha Ulluwishewa, Liang Wang, Callen Pereira, Stephanie Flynn, Elizabeth Cain, Stephen Stick, F. Jerry Reen, Joshua P. Ramsay, Fergal O’Gara
Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus
published pages: 1398-1406, ISSN: 1350-0872, DOI: 10.1099/mic.0.000317
Microbiology 162/8 2020-01-28
2016 J. P. Phelan, F. J. Reen, N. Dunphy, R. O’Connor, F. O’Gara
Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models
published pages: , ISSN: 1471-2407, DOI: 10.1186/s12885-016-2528-2
BMC Cancer 16/1 2020-01-28
2015 Rafael Bargiela, Christoph Gertler, Mirko Magagnini, Francesca Mapelli, Jianwei Chen, Daniele Daffonchio, Peter N. Golyshin, Manuel Ferrer
Degradation Network Reconstruction in Uric Acid and Ammonium Amendments in Oil-Degrading Marine Microcosms Guided by Metagenomic Data
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2015.01270
Frontiers in Microbiology 6 2020-01-28
2015 Manuel Ferrer, Rafael Bargiela, Mónica Martínez-Martínez, Jaume Mir, Rainhard Koch, Olga V. Golyshina, Peter N. Golyshin
Biodiversity for biocatalysis: A review of the α/β-hydrolase fold superfamily of esterases-lipases discovered in metagenomes
published pages: 235-249, ISSN: 1024-2422, DOI: 10.3109/10242422.2016.1151416
Biocatalysis and Biotransformation 33/5-6 2020-01-28
2016 Olga V. Golyshina, Peter N. Golyshin, Nadine I. Goldenstein, Heinrich Lünsdorf, Kai-Uwe Hinrichs, Ilya V. Kublanov
The novel extremely acidophilic, cell-wall-deficient archaeon Cuniculiplasma divulgatum gen. nov., sp. nov. represents a new family, Cuniculiplasmataceae fam. nov., of the order Thermoplasmatales
published pages: 332-340, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.000725
International Journal of Systematic and Evolutionary Microbiology 66/1 2020-01-28
2016 F. Jerry Reen, Jose A. Gutiérrez-Barranquero, Fergal O’Gara
Mining microbial signals for enhanced biodiscovery of secondary metabolites
published pages: 287-300, ISSN: , DOI: 10.1007/978-1-4939-6691-2_19
Methods in Molecular Biology 2020-01-28
2015 Rafael Bargiela, Francesca Mapelli, David Rojo, Bessem Chouaia, Jesús Tornés, Sara Borin, Michael Richter, Mercedes V. Del Pozo, Simone Cappello, Christoph Gertler, María Genovese, Renata Denaro, Mónica Martínez-Martínez, Stilianos Fodelianakis, Ranya A. Amer, David Bigazzi, Xifang Han, Jianwei Chen, Tatyana N. Chernikova, Olga V. Golyshina, Mouna Mahjoubi, Atef Jaouanil, Fatima Benzha, Mirko Magagnini, Emad Hussein, Fuad Al-Horani, Ameur Cherif, Mohamed Blaghen, Yasser R. Abdel-Fattah, Nicolas Kalogerakis, Coral Barbas, Hanan I. Malkawi, Peter N. Golyshin, Michail M. Yakimov, Daniele Daffonchio, Manuel Ferrer
Bacterial population and biodegradation potential in chronically crude oil-contaminated marine sediments are strongly linked to temperature
published pages: 11651, ISSN: 2045-2322, DOI: 10.1038/srep11651
Scientific Reports 5 2020-01-28
2016 Thomas Classen, Filip Kovacic, Benjamin Lauinger, Jörg Pietruszka, Karl-Erich Jaeger
Screening for Enantioselective Lipases
published pages: , ISSN: , DOI: 10.1007/8623_2016_218
Springer Protocols Handbooks 2020-01-28
2016 Carla C. C. R. de Carvalho
Whole cell biocatalysts: essential workers from Nature to the industry
published pages: , ISSN: 1751-7915, DOI: 10.1111/1751-7915.12363
Microbial Biotechnology 2020-01-28
2017 Carlos J. C. Rodrigues, Ricardo F.S. Pereira, Pedro Fernandes, Joaquim M.S. Cabral, Carla C. C. R. de Carvalho
Cultivation-based strategies to find efficient marine biocatalysts
published pages: 1700036, ISSN: 1860-6768, DOI: 10.1002/biot.201700036
Biotechnology Journal 12/7 2020-01-28
2016 María Parages, José Gutiérrez-Barranquero, F. Reen, Alan Dobson, Fergal O’Gara
Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts
published pages: 62, ISSN: 1660-3397, DOI: 10.3390/md14030062
Marine Drugs 14/3 2020-01-28
2017 Alyah Buzid, F. Jerry Reen, Victor K. Langsi, Eoin Ó Muimhneacháin, Fergal O\'Gara, Gerard P. McGlacken, John H. T. Luong, Jeremy D. Glennon
Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption
published pages: 533-541, ISSN: 2196-0216, DOI: 10.1002/celc.201600590
ChemElectroChem 4/3 2020-01-28
2015 Rafael Bargiela, Florian-Alexander Herbst, Mónica Martínez-Martínez, Jana Seifert, David Rojo, Simone Cappello, María Genovese, Francesca Crisafi, Renata Denaro, Tatyana N. Chernikova, Coral Barbas, Martin von Bergen, Michail M. Yakimov, Manuel Ferrer, Peter N. Golyshin
Metaproteomics and metabolomics analyses of chronically petroleum-polluted sites reveal the importance of general anaerobic processes uncoupled with degradation
published pages: 3508-3520, ISSN: 1615-9853, DOI: 10.1002/pmic.201400614
PROTEOMICS 15/20 2020-01-28
2016 M. Rita Correro, Michael Takacs, Sabine Sykora, Philippe F.-X. Corvini, Patrick Shahgaldian
Supramolecular enzyme engineering in complex nanometer-thin biomimetic organosilica layers
published pages: 89966-89971, ISSN: 2046-2069, DOI: 10.1039/C6RA17775A
RSC Adv. 6/92 2020-01-28
2016 Stephan Thies, Sonja Christina Rausch, Filip Kovacic, Alexandra Schmidt-Thaler, Susanne Wilhelm, Frank Rosenau, Rolf Daniel, Wolfgang Streit, Jörg Pietruszka, Karl-Erich Jaeger
Metagenomic discovery of novel enzymes and biosurfactants in a slaughterhouse biofilm microbial community
published pages: 27035, ISSN: 2045-2322, DOI: 10.1038/srep27035
Scientific Reports 6 2020-01-28
2017 Dimitry Y Sorokin, Enzo Messina, Francesco Smedile, Pawel Roman, Jaap S Sinninghe Damsté, Sergio Ciordia, Maria Carmen Mena, Manuel Ferrer, Peter N Golyshin, Ilya V Kublanov, Nazar I Samarov, Stepan V Toshchakov, Violetta La Cono, Michail M Yakimov
Discovery of anaerobic lithoheterotrophic haloarchaea, ubiquitous in hypersaline habitats
published pages: 1245-1260, ISSN: 1751-7362, DOI: 10.1038/ismej.2016.203
The ISME Journal 11/5 2020-01-28
2017 Rachel Shanahan, F. Jerry Reen, Rafael Cano, Fergal O\'Gara, Gerard P. McGlacken
The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
published pages: 306-310, ISSN: 1477-0520, DOI: 10.1039/C6OB01930G
Org. Biomol. Chem. 15/2 2020-01-28
2016 Stefano Romano, Antonio Fernàndez-Guerra, F. Jerry Reen, Frank O. Glöckner, Susan P. Crowley, Orla O\'Sullivan, Paul D. Cotter, Claire Adams, Alan D. W. Dobson, Fergal O\'Gara
Comparative Genomic Analysis Reveals a Diverse Repertoire of Genes Involved in Prokaryote-Eukaryote Interactions within the Pseudovibrio Genus
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.00387
Frontiers in Microbiology 7 2020-01-28
2016 Alyah Buzid, Fengjun Shang, F. Jerry Reen, Eoin Ó Muimhneacháin, Sarah L. Clarke, Lin Zhou, John H. T. Luong, Fergal O’Gara, Gerard P. McGlacken, Jeremy D. Glennon
Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep30001
Scientific Reports 6/1 2020-01-28
2016 Nadine Katzke, Andreas Knapp, Anita Loeschcke, Thomas Drepper, Karl-Erich Jaeger
Novel Tools for the Functional Expression of Metagenomic DNA
published pages: 159-196, ISSN: , DOI: 10.1007/978-1-4939-6691-2_10
Novel Tools for the Functional Expression of Metagenomic DNA Meth. Mol. Biol 2020-01-28
2017 Ana Popovic, Tran Hai, Anatoly Tchigvintsev, Mahbod Hajighasemi, Boguslaw Nocek, Anna N. Khusnutdinova, Greg Brown, Julia Glinos, Robert Flick, Tatiana Skarina, Tatyana N. Chernikova, Veronica Yim, Thomas Brüls, Denis Le Paslier, Michail M. Yakimov, Andrzej Joachimiak, Manuel Ferrer, Olga V. Golyshina, Alexei Savchenko, Peter N. Golyshin, Alexander F. Yakunin
Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families
published pages: 44103, ISSN: 2045-2322, DOI: 10.1038/srep44103
Scientific Reports 7 2020-01-28
2016 Alyah Buzid, Eoin Ó Muimhneacháin, F. Jerry Reen, Phyllis E. Hayes, Leticia M. Pardo, Fengjun Shang, Fergal O’Gara, Jonathan Sperry, John H. T. Luong, Jeremy D. Glennon, Gerard P. McGlacken
Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa
published pages: 6361-6367, ISSN: 1618-2642, DOI: 10.1007/s00216-016-9749-8
Analytical and Bioanalytical Chemistry 408/23 2020-01-28
2016 Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte, Manuel Ferrer
High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review
published pages: 605-615, ISSN: 1386-2073, DOI: 10.2174/1386207319666151110123927
Combinatorial Chemistry & High Throughput Screening 19/8 2020-01-28
2016 F. Jerry Reen, Stephanie Flynn, David F. Woods, Niall Dunphy, Muireann Ní Chróinín, David Mullane, Stephen Stick, Claire Adams, Fergal O’Gara
Bile signalling promotes chronic respiratory infections and antibiotic tolerance
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep29768
Scientific Reports 6/1 2020-01-28
2016 F. Jerry Reen, John P. Phelan, David F. Woods, Rachel Shanahan, Rafael Cano, Sarah Clarke, Gerard P. McGlacken, Fergal O’Gara
Harnessing Bacterial Signals for Suppression of Biofilm Formation in the Nosocomial Fungal Pathogen Aspergillus fumigatus
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.02074
Frontiers in Microbiology 7 2020-01-28
2016 Mercedes Ramírez-Escudero, Mercedes V. del Pozo, Julia Marín-Navarro, Beatriz González, Peter N. Golyshin, Julio Polaina, Manuel Ferrer, Julia Sanz-Aparicio
Structural and Functional Characterization of a Ruminal β-Glycosidase Defines a Novel Subfamily of Glycoside Hydrolase Family 3 with Permuted Domain Topology
published pages: 24200-24214, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.747527
Journal of Biological Chemistry 291/46 2020-01-28
2016 M. Rita Correro, Negar Moridi, Hansjörg Schützinger, Sabine Sykora, Erik M. Ammann, E. Henrik Peters, Yves Dudal, Philippe F.-X. Corvini, Patrick Shahgaldian
Enzyme Shielding in an Enzyme-thin and Soft Organosilica Layer
published pages: 6285-6289, ISSN: 1433-7851, DOI: 10.1002/anie.201600590
Angewandte Chemie International Edition 55/21 2020-01-28
2016 Emma Hennessy, Claire Adams, F. Jerry Reen, Fergal O\'Gara
Is There Potential for Repurposing Statins as Novel Antimicrobials?
published pages: 5111-5121, ISSN: 0066-4804, DOI: 10.1128/AAC.00192-16
Antimicrobial Agents and Chemotherapy 60/9 2020-01-28
2015 Antonio Placido, Tran Hai, Manuel Ferrer, Tatyana N. Chernikova, Marco Distaso, Dale Armstrong, Alexander F. Yakunin, Stepan V. Toshchakov, Michail M. Yakimov, Ilya V. Kublanov, Olga V. Golyshina, Graziano Pesole, Luigi R. Ceci, Peter N. Golyshin
Diversity of hydrolases from hydrothermal vent sediments of the Levante Bay, Vulcano Island (Aeolian archipelago) identified by activity-based metagenomics and biochemical characterization of new esterases and an arabinopyranosidase
published pages: 10031-10046, ISSN: 0175-7598, DOI: 10.1007/s00253-015-6873-x
Applied Microbiology and Biotechnology 99/23 2020-01-28

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