CARBAZYMES
Sustainable industrial processes based on a C-C bond-forming enzyme platform
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the CARBAZYMES project. It provides you a very rough idea of what is the project "CARBAZYMES" about.
Project "CARBAZYMES" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITAT DARMSTADT
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://www.carbazymes.com/ |
| Total cost | 9˙251˙355 € |
| EC max contribution | 8˙202˙966 € (89%) |
| Programme |
1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology) |
| Code Call | H2020-LEIT-BIO-2014-1 |
| Funding Scheme | IA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2019-03-31 |
Partnership
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Project objective
C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project. Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners. CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.
Deliverables
| International Outreach Symposium | Other | 2020-02-06 14:56:19 |
| Fourth set of scientific publications | Websites, patent fillings, videos etc. | 2020-02-06 14:56:19 |
| Project website | Websites, patent fillings, videos etc. | 2020-02-06 14:56:18 |
| Second set of scientific publications | Websites, patent fillings, videos etc. | 2020-02-06 14:56:18 |
| Publicity materials | Other | 2020-02-06 14:56:18 |
| Dissemination and branding standards | Websites, patent fillings, videos etc. | 2020-02-06 14:56:18 |
| First set of scientific publications | Websites, patent fillings, videos etc. | 2020-02-06 14:56:18 |
| Posts, press releases, news items | Websites, patent fillings, videos etc. | 2020-02-06 14:56:18 |
| Third set of scientific publications | Websites, patent fillings, videos etc. | 2020-02-06 14:56:18 |
Take a look to the deliverables list in detail: detailed list of CARBAZYMES deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Chao Guo, Mohammad Saifuddin, Thangavelu Saravanan, Masih Sharifi, Gerrit J. Poelarends Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates published pages: 4369-4373, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b00780 |
ACS Catalysis 9/5 | 2020-02-06 |
| 2019 |
Anera Å varc, Zvjezdana Findrik Blažević, ÄurÄ‘a Vasićâ€RaÄki, Anna Szekrenyi, Wolfâ€Dieter Fessner, Simon J Charnock, Ana Vrsalović PreseÄki 2â€Deoxyriboseâ€5â€phosphate aldolase from Thermotoga maritima in the synthesis of a statin sideâ€chain precursor: characterization, modeling and optimization published pages: 1832-1842, ISSN: 0268-2575, DOI: 10.1002/jctb.5956 |
Journal of Chemical Technology & Biotechnology 94/6 | 2020-02-06 |
| 2018 |
Anders O. Magnusson, Anna Szekrenyi, Henkâ€Jan Joosten, James Finnigan, Simon Charnock, Wolfâ€Dieter Fessner nanoDSF as screening tool for enzyme libraries and biotechnology development published pages: 184-204, ISSN: 1742-464X, DOI: 10.1111/febs.14696 |
The FEBS Journal 286/1 | 2020-02-06 |
| 2018 |
Raquel Roldán, Karel Hernandez, Jesús Joglar, Jordi Bujons, Teodor Parella, Israel Sánchez-Moreno, Virgil Hélaine, Marielle Lemaire, Christine Guérard-Hélaine, Wolf-Dieter Fessner, Pere Clapés Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes published pages: 8804-8809, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b02486 |
ACS Catalysis 8/9 | 2020-02-06 |
| 2018 |
Millán, Claudia; Sammito, Massimo; McCoy, Airlie; Nascimento, Andrey F Ziem; Petrillo, Giovanna; Oeffner, Robert; DomÃnguez-Gil, Teresa; Hermoso, Juan A; Read, Randy; Usón, Isabel Exploiting distant homologues for phasing through the generation of compact fragments, local fold refinement and partial solution combination. published pages: D74, 290–304, ISSN: 2059-7983, DOI: 10.17863/CAM.25122 |
Acta Crystallographica. Section D, Structural Biology 6 | 2020-02-06 |
| 2019 |
M. Sudar Application of Chemical Engineering Methodology in Process Development: A Case Study of MenD-catalyzed Synthesis of 6-Cyano-4-oxohexanoic Acid published pages: 501-510, ISSN: 0352-9568, DOI: 10.15255/cabeq.2018.1393 |
Chemical and Biochemical Engineering Quarterly 32/4 | 2020-02-06 |
| 2018 |
Sabrina Hampel, Jan-Patrick Steitz, Anna Baierl, Patrizia Lehwald, Luzia Wiesli, Michael Richter, Alexander Fries, Martina Pohl, Gunter Schneider, Doreen Dobritzsch, Michael Müller Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens published pages: 2283-2292, ISSN: 1439-4227, DOI: 10.1002/cbic.201800325 |
ChemBioChem 19/21 | 2020-02-06 |
| 2019 |
Raquel Roldán, Karel Hernández, Jesús Joglar, Jordi Bujons, Teodor Parella, Wolf-Dieter Fessner, Pere Clapés Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes published pages: 361, 1–16, ISSN: 1615-4150, DOI: 10.1002/adsc.201801530 |
Advanced Synthesis & Catalysis Adv. Synth. Catal. | 2020-02-06 |
| 2018 |
Sebastian Junker, Raquel Roldan, Henk-Jan Joosten, Pere Clapés, Wolf-Dieter Fessner Complete Switch of Reaction Specificity of an Aldolase by Directed Evolution In Vitro: Synthesis of Generic Aliphatic Aldol Products published pages: 10153-10157, ISSN: 1433-7851, DOI: 10.1002/anie.201804831 |
Angewandte Chemie International Edition 57/32 | 2020-02-06 |
| 2019 |
Lieuwe Biewenga, Thangavelu Saravanan, Andreas Kunzendorf, Jan-Ytzen van der Meer, Tjaard Pijning, Pieter G. Tepper, Ronald van Merkerk, Simon J. Charnock, Andy-Mark W. H. Thunnissen, Gerrit J. Poelarends Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions published pages: 1503-1513, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b04299 |
ACS Catalysis 9/2 | 2020-02-06 |
| 2019 |
Elia Calderini, Julia Wessel, Philipp Süss, Patrick Schrepfer, Rainer Wardenga, Anett Schallmey Selective Ringâ€Opening of Diâ€Substituted Epoxides Catalysed by Halohydrin Dehalogenases published pages: 2099-2106, ISSN: 1867-3880, DOI: 10.1002/cctc.201900103 |
ChemCatChem 11/8 | 2020-02-06 |
| 2016 |
Jan-Ytzen van der Meer, Lieuwe Biewenga, Gerrit J. Poelarends The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201600382 |
ChemBioChem | 2020-02-06 |
| 2017 |
Karel Hernandez, Jordi Bujons, Jesús Joglar, Simon J. Charnock, Pablo DomÃnguez de MarÃa, Wolf Dieter Fessner, Pere Clapés Combining Aldolases and Transaminases for the Synthesis of 2-Amino-4-hydroxybutanoic Acid published pages: 1707-1711, ISSN: 2155-5435, DOI: 10.1021/acscatal.6b03181 |
ACS Catalysis 7/3 | 2020-02-06 |
| 2017 |
José Berenguer, Mario MencÃa, Aurelio Hidalgo Are in vivo selections on the path to extinction? published pages: 46-49, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12490 |
Microbial Biotechnology 10/1 | 2020-02-06 |
| 2016 |
Anett Schallmey, Marcus Schallmey Recent advances on halohydrin dehalogenases—from enzyme identification to novel biocatalytic applications published pages: 7827-7839, ISSN: 0175-7598, DOI: 10.1007/s00253-016-7750-y |
Applied Microbiology and Biotechnology 100/18 | 2020-02-06 |
| 2018 |
Yen-Chi Thai, Anna Szekrenyi, Yuyin Qi, Gary W. Black, Simon J. Charnock, Wolf-Dieter Fessner Fluorogenic kinetic assay for high-throughput discovery of stereoselective ketoreductases relevant to pharmaceutical synthesis published pages: 1320-1326, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.05.024 |
Bioorganic & Medicinal Chemistry 26/7 | 2020-02-06 |
| 2018 |
Karel Hernández, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés Cover Picture: Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli (Angew. Chem. Int. Ed. 14/2018) published pages: 3521-3521, ISSN: 1433-7851, DOI: 10.1002/anie.201802275 |
Angewandte Chemie International Edition 57/14 | 2020-02-06 |
| 2017 |
Karel Hernández, Ariadna Gómez, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés 2-Keto-3-Deoxy- l -Rhamnonate Aldolase (YfaU) as Catalyst in Aldol Additions of Pyruvate to Amino Aldehyde Derivatives published pages: 2090-2100, ISSN: 1615-4150, DOI: 10.1002/adsc.201700360 |
Advanced Synthesis & Catalysis 359/12 | 2020-02-06 |
| 2018 |
Martina Sudar, ÄurÄ‘a Vasić-RaÄki, Michael Müller, Alexandra Walter, Zvjezdana Findrik Blažević Mathematical model of the MenD-catalyzed 1,4-addition (Stetter reaction) of α-ketoglutaric acid to acrylonitrile published pages: 71-80, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2018.01.013 |
Journal of Biotechnology 268 | 2020-02-06 |
| 2018 |
Karel Hernández, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli published pages: 3645-3649, ISSN: 0044-8249, DOI: 10.1002/ange.201711289 |
Angewandte Chemie 130/14 | 2020-02-06 |
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