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MAGICBULLET

Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MAGICBULLET project word cloud

Explore the words cloud of the MAGICBULLET project. It provides you a very rough idea of what is the project "MAGICBULLET" about.

peers antibody cellular selective peptides selectively relies combining anticancer potent penetrating payloads drugs explore manufacturing suitable synthetic scientific demand loading endocytosis newly conjugates respect prepared molecular cytotoxic adc conformational magicbullet straightforward cancer structures antigens introductory toward designed medicinal pharmacology peptide cells molecules limitations additional homogenous covers biology tumors teaching either certain cell combination nobel recognize paul spectroscopy innovative conjugation warheads overexpression skills treatment training etn bullet tissue many multilingualism form chemistry tumor vectors validate ehrlich therapy concerted discovered approved penetrate laureate drug magic biochemistry multidisciplinary bench easily learning organ vector hands computational penetration fight mediated mechanisms homing array metastatic investigations

Project "MAGICBULLET" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.magicbullet.de
Total cost	3˙746˙420 €
EC max contribution	3˙746˙420 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET BIELEFELD UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	coordinator	498˙432.00
2	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	538˙290.00
3	UNIVERSITA DEGLI STUDI DELL'INSUBRIA UNIVERSITA DEGLI STUDI DELL'INSUBRIA Organization address address: VIA RAVASI 2 city: VARESE postcode: 21100 website: www.uninsubria.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VARESE)	participant	516˙122.00
4	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	516˙122.00
5	HEIDELBERG PHARMA RESEARCH GMBH HEIDELBERG PHARMA RESEARCH GMBH Organization address address: SCHRIESHEIMER STRASSE 101 city: LADENBURG postcode: 68526 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LADENBURG)	participant	498˙432.00
6	EOTVOS LORAND TUDOMANYEGYETEM EOTVOS LORAND TUDOMANYEGYETEM Organization address address: EGYETEM TER 1-3 city: BUDAPEST postcode: 1053 website: www.elte.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	447˙827.00
7	EXIRIS SRL EXIRIS SRL Organization address address: VIA SAVONA INT 2 B 6 city: ROMA postcode: 182 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	258˙061.00
8	UNIVERSITAET ZU KOELN UNIVERSITAET ZU KOELN Organization address address: ALBERTUS MAGNUS PLATZ city: KOELN postcode: 50931 website: www.uni-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	249˙216.00
9	Orszagos Onkologiai Intezet Orszagos Onkologiai Intezet Organization address address: RATH GYORGY UTCA 7-9. city: Budapest postcode: 1122 website: www.oncol.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (Budapest)	participant	223˙913.00
10	Bayer Pharma AG Bayer Pharma AG Organization address address: Muellerstrasse 178 city: Berlin postcode: 13353 website: www.bayerpharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Berlin)	partner	0.00
11	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	partner	0.00
12	FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG Organization address address: SCHLOSSPLATZ 4 city: ERLANGEN postcode: 91054 website: www.uni-erlangen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ERLANGEN)	partner	0.00
13	IRBM SCIENCE PARK SPA IRBM SCIENCE PARK SPA Organization address address: VIA PONTINA KM 30600 city: POMEZIA RM postcode: 40 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (POMEZIA RM)	partner	0.00
14	Kineto Lab Ltd. Kineto Lab Ltd. Organization address address: Zápor u. 55. city: Budapest postcode: H-1032 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (Budapest)	partner	0.00

Map

Project objective

Many tumor cells are characterized by the overexpression of certain antigens. Molecules that specifically recognize these structures are suitable as homing devices in tumor therapy. Conjugates of anticancer drugs with such a delivery vector targeting tumors would be a “magic bullet” according to the Nobel laureate Paul Ehrlich. Three antibody-drug conjugates (ADC) have already been approved for anticancer therapy. However, ADC have e.g. limitations with respect to tumor penetration, high manufacturing costs, and require challenging conjugation chemistry. Peptide-drug conjugates can have a high drug loading, easily penetrate tissue, and can be easily prepared in a homogenous form with straightforward and well-defined conjugation chemistry. The ETN MAGICBULLET will focus on chemistry-driven approaches toward conjugates between peptides (delivery vectors) that recognize tumors and anticancer drugs (payloads or warheads) in order to selectively fight cancer, a topic with a high demand of research activities. The ETN will develop and validate an array of new peptide-drug conjugates combining either known tumor-specific peptides or newly discovered tumor-homing peptides with potent cytotoxic drugs. The tumor-selective peptides are designed for cellular uptake mediated either by endocytosis or by cell-penetrating peptides. The consortium of the ETN MAGICBULLET covers tumor biology, biochemistry, pharmacology, synthetic chemistry, medicinal chemistry, spectroscopy, conformational analysis, and computational chemistry. The training program focuses on multidisciplinary research to explore and validate molecular targets for innovative treatment or investigations on the molecular mechanisms in organ-specific metastatic growth processes. It aims at scientific multilingualism and relies e.g. on concerted learning, a combination of introductory training, hands-on learning “on the bench”, teaching by peers, and training in additional skills.

Deliverables

List of deliverables.
Summer School	Other	2019-07-23 08:35:18
Feature article on Peptide-Drug Conjugates	Documents, reports	2019-07-23 08:35:18
Videos	Websites, patent fillings, videos etc.	2019-07-23 08:35:18
Special issue on Peptide-Drug Conjugates	Documents, reports	2019-07-23 08:35:18
International Network Symposium	Other	2019-07-23 08:35:18
Completion of Website	Websites, patent fillings, videos etc.	2019-07-23 08:35:17

Take a look to the deliverables list in detail: detailed list of MAGICBULLET deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Eduard Figueras, Adina BorbÃ©ly, Mohamed Ismail, Marcel Frese, Norbert Sewald Novel unit B cryptophycin analogues as payloads for targeted therapy published pages: 1281-1286, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.109	Beilstein Journal of Organic Chemistry 14	2019-07-23
2018	Andrea Angelo Pierluigi Tripodi, SzilÃ¡rd TÃ³th, Kata NÃ³ra Enyedi, Gitta Schlosser, Gergely SzakÃ¡cs, GÃ¡bor MezÅ‘ Development of novel cyclic NGR peptideâ€“daunomycin conjugates with dual targeting property published pages: 911-918, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.78	Beilstein Journal of Organic Chemistry 14	2019-07-23
2018	Lizeth Bodero, Paula LÃ³pez Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl, Christoph MÃ¼ller, Daniela Arosio, Luca Pignataro, Cesare Gennari, Umberto Piarulli Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-Î±-amanitin conjugates for tumor-targeting published pages: 407-415, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.29	Beilstein Journal of Organic Chemistry 14	2019-07-23
2018	Samuele Cazzamalli, Eduard Figueras, Lilla PethÅ‘, Adina BorbÃ©ly, Christian SteinkÃ¼hler, Dario Neri, Norbert Sewald In Vivo Antitumor Activity of a Novel Acetazolamideâ€“Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas published pages: 14726-14731, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b02350	ACS Omega 3/11	2019-07-23
2017	Christine Weiss, Eduard Figueras, Adina N. Borbely, Norbert Sewald Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting published pages: 514-531, ISSN: 1075-2617, DOI: 10.1002/psc.3015	Journal of Peptide Science 23/7-8	2019-07-23
2018	Sabine Schuster, BeÃ¡ta Biri-KovÃ¡cs, BÃ¡lint Szeder, LÃ¡szlÃ³ Buday, JÃ¡nos Gardi, Zsuzsanna SzabÃ³, GÃ¡bor Halmos, GÃ¡bor MezÅ‘ Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification published pages: 223, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10040223	Pharmaceutics 10/4	2019-07-23
2018	Paula LÃ³pez Rivas, Ivan RanÄ‘eloviÄ‡, AndrÃ© Raposo Moreira Dias, Arianna Pina, Daniela Arosio, JÃ³zsef TÃ³vÃ¡ri, GÃ¡bor MezÅ‘, Alberto Dal Corso, Luca Pignataro, Cesare Gennari Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Linkers Cleavable by Lysosomal Enzymes and Î± V Î² 3 -Integrin Ligands for Tumor Targeting published pages: 2902-2909, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800447	European Journal of Organic Chemistry 2018/23	2019-07-23
2017	Anja Gronewold, Mareike Horn, Ivan RanÄ‘eloviÄ‡, Dr. JÃ³zsef TÃ³vÃ¡ri, Sergio MuÃ±ozâ€…VÃ¡zquez, Prof.â€…Dr. Klaus SchomÃ¤cker, Prof.â€…Dr. Ines Neundorf Characterization of a Cell-Penetrating Peptide with Potential Anticancer Activity published pages: 42â€“49, ISSN: 1860-7187, DOI: 10.1002/cmdc.201600498	ChemMedChem Januar 5, 2017, Volume 12, Issu	2019-07-23
2017	Simone Zanella, Simona Angerani, Arianna Pina, Paula LÃ³pezâ€…Rivas, Clelia Giannini, Silvia Panzeri, Daniela Arosio, Michele Caruso, Fabio Gasparri, Ivan Fraietta, Clara Albanese, Aurelio Marsiglio, Luca Pignataro, Laura Belvisi, Umberto Piarulli, Cesare Gennari Tumor Targeting with an iso DGR-Drug Conjugate published pages: 7910-7914, ISSN: 0947-6539, DOI: 10.1002/chem.201701844	Chemistry - A European Journal 23/33	2019-07-23
2017	AndrÃ© Raposoâ€…Moreiraâ€…Dias, Arianna Pina, Alberto Dalâ€…Corso, Daniela Arosio, Laura Belvisi, Luca Pignataro, Michele Caruso, Cesare Gennari Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin Î± V Î² 3 published pages: 14410-14415, ISSN: 0947-6539, DOI: 10.1002/chem.201703093	Chemistry - A European Journal 23/58	2019-07-23
2018	Sabine Schuster, BeÃ¡ta Biri-KovÃ¡cs, BÃ¡lint Szeder, Viktor Farkas, LÃ¡szlÃ³ Buday, Zsuzsanna SzabÃ³, GÃ¡bor Halmos, GÃ¡bor MezÅ‘ Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicinâ€“GnRH-III conjugates developed for targeted drug delivery published pages: 756-771, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.64	Beilstein Journal of Organic Chemistry 14	2019-07-23
2017	Lucia Feni, M. Omrane, Moritz Fischer, Boris Zlatopolskiy, Bernd Neumaier, Ines Neundorf Convenient Preparation of 18F-Labeled Peptide Probes for Potential Claudin-4 PET Imaging published pages: 99, ISSN: 1424-8247, DOI: 10.3390/ph10040099	Pharmaceuticals 10/4	2019-07-23

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