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SAPHELY

Self-amplified photonic biosensing platform for microRNA-based early diagnosis of diseases

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SAPHELY project word cloud

Explore the words cloud of the SAPHELY project. It provides you a very rough idea of what is the project "SAPHELY" about.

lasers validation lt consequent cancer hybridization clinical diagnosis mirna sensitive 3000 ultra events free direct size scheme special programs small point fast commercialisation bandgap affordable preclinical detection structures academic care label index mass device tuneable labelling surface molecular nanophotonic volume sensitivity significantly heavy attached saphely difficult probes avoids weight chip nanoparticles power biomarkers microrna readout envisaged spectrometers poc bulky translated rates displacement involvement pm self capture explore beacon treatments sensing technique diseases bloodstream industrial survival mu disease screening blood reducing invasive photonic amplification deploying minimally deployment pcr paid identification expensive sub minutes nanoparticle sensor handheld

Project "SAPHELY" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT POLITECNICA DE VALENCIA Organization address address: CAMINO DE VERA SN EDIFICIO 3A city: VALENCIA postcode: 46022 website: www.upv.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://saphely.eu/
Total cost	3˙228˙838 €
EC max contribution	3˙228˙838 € (100%)
Programme	1. H2020-EU.2.1.1.6. (Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies)
Code Call	H2020-ICT-2014-1
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT POLITECNICA DE VALENCIA UNIVERSITAT POLITECNICA DE VALENCIA Organization address address: CAMINO DE VERA SN EDIFICIO 3A city: VALENCIA postcode: 46022 website: www.upv.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	coordinator	945˙704.00
2	MICROFLUIDIC CHIPSHOP GMBH MICROFLUIDIC CHIPSHOP GMBH Organization address address: STOCKHOLMER STRASSE 20 city: JENA postcode: 7747 website: www.microfluidic-ChipShop.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	participant	443˙750.00
3	APR TECHNOLOGIES AB APR TECHNOLOGIES AB Organization address address: Vaestra Jaernvaegsgatan 4 city: ENKOEPING postcode: 745 39 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (ENKOEPING)	participant	370˙081.00
4	AALBORG UNIVERSITET AALBORG UNIVERSITET Organization address address: FREDRIK BAJERS VEJ 7K city: AALBORG postcode: 9220 website: www.aau.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AALBORG)	participant	344˙915.00
5	UNIVERSITY OF EAST ANGLIA UNIVERSITY OF EAST ANGLIA Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ website: http://www.uea.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	participant	323˙513.00
6	MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH Organization address address: BISMARCKSTRASSE 142B city: DUISBURG postcode: 47057 website: www.microtec-d.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUISBURG)	participant	226˙250.00
7	Fundación Instituto Valenciano de Oncología Fundación Instituto Valenciano de Oncología Organization address address: Beltrán Báguena 8 city: VALENCIA postcode: 46009 website: www.ivo.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	215˙625.00
8	EV GROUP E. THALLNER GMBH EV GROUP E. THALLNER GMBH Organization address address: DI ERICH THALLNER STRASSE 1 city: ST FLORIAN AM INN postcode: 4782 website: www.evgroup.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (ST FLORIAN AM INN)	participant	207˙750.00
9	MEDICAL ENGINEERING TECHNOLOGIES LTD MEDICAL ENGINEERING TECHNOLOGIES LTD Organization address address: UNIT 16 HOLMESTONE ROAD city: DOVER postcode: CT17 0UF website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (DOVER)	participant	151˙250.00

Map

Project objective

The SAPHELY project focuses on the development and the preclinical validation of a nanophotonic-based handheld point-of-care (POC) analysis device for its application to the minimally-invasive early diagnosis of diseases, with a focus in cancer. Disease identification will be based in the fast (<5 minutes), ultra-sensitive (sub-pM) and label-free detection of novel highly-specific microRNA (miRNA) biomarkers, using a small volume of whole blood (<100 μL). This POC analysis device, which will have a low cost (envisaged cost < €3000), will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates. The ultra-high sensitivity required for the direct detection of miRNA biomarkers present in the bloodstream will be achieved by using a novel sensing amplification technique. This technique is based in the use of molecular beacon capture probes with an attached high index nanoparticle, so that the hybridization events are translated into the displacement of these nanoparticles from the sensor surface. The use of this self-amplification technique avoids the use of complex PCR-based amplification methods or labelling processes, which are difficult to implement on-chip. The cost, size and weight reduction required for deploying an affordable handheld POC device will be achieved by using a novel power-based readout scheme for photonic bandgap sensing structures where the use of expensive, bulky and heavy tuneable lasers and spectrometers is avoided. Special attention will be paid within the SAPHELY project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.

Publications

List of publications.
year	authors and title	journal	last update
2017	Maria-Jose BaÃ±uls, Pilar JimÃ©nez-Meneses, Albert Meyer, Jean-Jacques Vasseur, FranÃ§ois Morvan, Jorge Escorihuela, Rosa Puchades, Ãngel Maquieira Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiolâ€“Ene or Thiolâ€“Yne Coupling Chemistry published pages: 496-506, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00624	Bioconjugate Chemistry 28/2	2019-05-30
2018	Ãngela Ruiz-TÃ³rtola, Francisco Prats-QuÃlez, Daniel GonzÃ¡lez-Lucas, MarÃa-JosÃ© BaÃ±uls, Ãngel Maquieira, Guy Wheeler, Tamas Dalmay, Amadeu Griol, Juan Hurtado, Jaime GarcÃa-RupÃ©rez High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes published pages: 1717, ISSN: 2156-7085, DOI: 10.1364/BOE.9.001717	Biomedical Optics Express 9/4	2019-05-30
2018	Ãngela Ruiz-TÃ³rtola, Francisco Prats-QuÃlez, Daniel GonzÃ¡lez-Lucas, MarÃa-JosÃ© BaÃ±uls, Ãngel Maquieira, Guy Wheeler, Tamas Dalmay, Amadeu Griol, Juan Hurtado, Helge Bohlmann, Reiner GÃ¶tzen, Jaime GarcÃa-RupÃ©rez Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes published pages: e201800030, ISSN: 1864-063X, DOI: 10.1002/jbio.201800030	Journal of Biophotonics	2019-05-30
2015	Catarina Oliveira Silva, Steffen B. Petersen, Catarina Pinto Reis, PatrÃcia Rijo, JesÃºs Molpeceres, Henrik Vorum, Maria Teresa Neves-Petersen Lysozyme Photochemistry as a Function of Temperature. The Protective Effect of Nanoparticles on Lysozyme Photostability published pages: e0144454, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0144454	PLOS ONE 10/12	2019-05-30
2017	Daniel GonzÃ¡lez-Lucas, MarÃa-JosÃ© BaÃ±uls, Jaime GarcÃa-RupÃ©rez, Ãngel Maquieira Covalent attachment of biotinylated molecular beacons via thiol-ene coupling. A study on conformational changes upon hybridization and streptavidin binding published pages: 3231-3238, ISSN: 0026-3672, DOI: 10.1007/s00604-017-2310-4	Microchimica Acta 184/9	2019-05-30

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