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MITOsmORFs SIGNED

Identification and analysis of novel mitochondrial proteins encoded by small open reading frames

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MITOsmORFs project word cloud

Explore the words cloud of the MITOsmORFs project. It provides you a very rough idea of what is the project "MITOsmORFs" about.

interaction small apoptosis yeast 15 metabolite quarters smorf constitute metabolomic organism functional localized vivo function genetic mitochondrial dubious remarkably budding possess date uncharacterized located kda proteome content deserves respiration biogenesis neurodegenerative initial proteomic fe energy cellular metabolism compartments morphology le biology mitochondria transport intracellular protein roles organelles unknown frame reading characterization signaling examples 10 cover encephalomyopathy discovered diseases model explore dysfunction demonstrated mitosmorfs causes cluster lipidomic frames organello mapping submitochondrial predict localization proteins cristae

Project "MITOsmORFs" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.biochemie.uni-freiburg.de/ag/wiedemann/ERC
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAETSKLINIKUM FREIBURG UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	coordinator	1˙094˙166.00
2	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Organization address address: FAHNENBERGPLATZ city: FREIBURG postcode: 79098 website: www.uni-freiburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	905˙833.00

Map

Project objective

Mitochondria are essential organelles with crucial roles in cellular energy metabolism, Fe-S cluster biogenesis, signaling and apoptosis. Mitochondrial dysfunction causes encephalomyopathy and neurodegenerative diseases. Mitochondria possess a remarkably high content of small proteins compared to other cellular compartments. About one third of the cellular proteins ≤15 kDa characterized to date are located in mitochondria. Functional examples of such small proteins cover the whole mitochondrial biology like cristae morphology, Fe-S cluster formation, metabolite transport, protein biogenesis and respiration. However, the intracellular localization and function of most small proteins is unknown. These small proteins constitute one third of the uncharacterized open reading frames and even three quarters of the dubious open reading frames in the model organism budding yeast. Taken together we predict that more than 10% of the mitochondrial proteome deserves to be discovered. In an initial study we demonstrated the mitochondrial localization of several uncharacterized small open reading frame (smORF) proteins. MITOsmORFs aims to identify over 100 novel small mitochondrial proteins. MITOsmORFs will determine the submitochondrial localization and the functional role of the novel mitochondrial proteins by genetic, proteomic, metabolomic and lipidomic analysis, including interaction mapping and characterization of mitochondrial activities in vivo and in organello to explore the unknown biology of smORF proteins localized to mitochondria.

Publications

List of publications.
year	authors and title	journal	last update
2019	Daqiang Pan, Nils Wiedemann, Bernd Kammerer Heat Stress-Induced Metabolic Remodeling in Saccharomyces cerevisiae published pages: 266, ISSN: 2218-1989, DOI: 10.3390/metabo9110266	Metabolites 9/11	2020-04-09
2020	Heike Rampelt, Iva Sucec, Beate Bersch, Patrick Horten, Inge Perschil, Jean-Claude Martinou, Martin van der Laan, Nils Wiedemann, Paul Schanda, Nikolaus Pfanner The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-019-0733-6	BMC Biology 18/1	2020-04-09
2017	Moritz Niemann, Anke Harsman, Jan Mani, Christian D. Peikert, Silke Oeljeklaus, Bettina Warscheid, Richard Wagner, AndrÃ© Schneider tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes published pages: E7679-E7687, ISSN: 0027-8424, DOI: 10.1073/pnas.1711430114	Proceedings of the National Academy of Sciences 114/37	2020-04-09
2017	Nataliia Naumenko, Marcel Morgenstern, Robert RucktÃ¤schel, Bettina Warscheid, Peter Rehling INA complex liaises the F1Fo-ATP synthase membrane motor modules published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01437-z	Nature Communications 8/1	2020-04-09
2018	Lena BÃ¶ttinger, Christoph U. MÃ¥rtensson, Jiyao Song, Nicole Zufall, Nils Wiedemann, Thomas Becker Respiratory chain supercomplexes associate with the cysteine desulfurase complex of the ironâ€“sulfur cluster assembly machinery published pages: 776-785, ISSN: 1059-1524, DOI: 10.1091/mbc.E17-09-0555	Molecular Biology of the Cell 29/7	2020-04-09
2017	Vivien KrÃ¼ger, Thomas Becker, Lars Becker, Malayko Montilla-Martinez, Lars Ellenrieder, F.-Nora VÃ¶gtle, Helmut E. Meyer, Michael T. Ryan, Nils Wiedemann, Bettina Warscheid, Nikolaus Pfanner, Richard Wagner, Chris Meisinger Identification of new channels by systematic analysis of the mitochondrial outer membrane published pages: 3485-3495, ISSN: 0021-9525, DOI: 10.1083/jcb.201706043	The Journal of Cell Biology 216/11	2020-04-09
2018	Daqiang Pan, Caroline Lindau, Simon Lagies, Nils Wiedemann, Bernd Kammerer Metabolic profiling of isolated mitochondria and cytoplasm reveals compartment-specific metabolic responses published pages: , ISSN: 1573-3882, DOI: 10.1007/s11306-018-1352-x	Metabolomics 14/5	2020-04-09
2017	Marcel Morgenstern, Sebastian B. Stiller, Philipp LÃ¼bbert, Christian D. Peikert, Stefan Dannenmaier, Friedel Drepper, Uri Weill, Philipp HÃ¶ÃŸ, Reinhild Feuerstein, Michael Gebert, Maria Bohnert, Martin van der Laan, Maya Schuldiner, Conny SchÃ¼tze, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale published pages: 2836-2852, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.06.014	Cell Reports 19/13	2020-04-09
2018	Ulrike Topf, Ida Suppanz, Lukasz Samluk, Lidia Wrobel, Alexander BÃ¶ser, Paulina Sakowska, Bettina Knapp, Martyna K. Pietrzyk, Agnieszka Chacinska, Bettina Warscheid Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02694-8	Nature Communications 9/1	2020-04-09
2018	Isotta Lorenzi, Silke Oeljeklaus, Abhishek Aich, Christin RonsÃ¶r, Sylvie Callegari, Jan Dudek, Bettina Warscheid, Sven Dennerlein, Peter Rehling The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis published pages: 323-333, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2017.11.010	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865/2	2020-04-09
2016	Nils Wiedemann, Nikolaus Pfanner Mitochondrial Machineries for Protein Import and Assembly published pages: , ISSN: 0066-4154, DOI: 10.1146/annurev-biochem-060815-014352	Annual Review of Biochemistry 86/1	2020-04-09
2016	Lars Ellenrieder, Åukasz OpaliÅ„ski, Lars Becker, Vivien KrÃ¼ger, Oliver Mirus, Sebastian P. Straub, Katharina Ebell, Nadine Flinner, Sebastian B. Stiller, Bernard Guiard, Chris Meisinger, Nils Wiedemann, Enrico Schleiff, Richard Wagner, Nikolaus Pfanner, Thomas Becker Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10 published pages: 13021, ISSN: 2041-1723, DOI: 10.1038/ncomms13021	Nature Communications 7	2020-04-09
2016	SebastianÂ B. Stiller, Jan HÃ¶pker, Silke Oeljeklaus, Conny SchÃ¼tze, SandraÂ G. Schrempp, Jens Vent-Schmidt, SusanneÂ E. Horvath, AnnÂ E. Frazier, Natalia Gebert, Martin vanÂ derÂ Laan, Maria Bohnert, Bettina Warscheid, Nikolaus Pfanner, Nils Wiedemann Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins published pages: 901-908, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2016.04.005	Cell Metabolism 23/5	2020-04-09
2016	Sebastian P. Straub, Sebastian B. Stiller, Nils Wiedemann, Nikolaus Pfanner Dynamic organization of the mitochondrial protein import machinery published pages: , ISSN: 1431-6730, DOI: 10.1515/hsz-2016-0145	Biological Chemistry 397/11	2020-04-09
2016	Ido Yofe, Uri Weill, Matthias Meurer, Silvia Chuartzman, Einat Zalckvar, Omer Goldman, Shifra Ben-Dor, Conny SchÃ¼tze, Nils Wiedemann, Michael Knop, Anton Khmelinskii, Maya Schuldiner One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy published pages: 371-378, ISSN: 1548-7091, DOI: 10.1038/nmeth.3795	Nature Methods 13/4	2020-04-09
2018	Stefan Dannenmaier, Sebastian B. Stiller, Marcel Morgenstern, Philipp LÃ¼bbert, Silke Oeljeklaus, Nils Wiedemann, Bettina Warscheid Complete Native Stable Isotope Labeling by Amino Acids of Saccharomyces cerevisiae for Global Proteomic Analysis published pages: 10501-10509, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b02557	Analytical Chemistry 90/17	2020-04-09
2018	Katharina WeinhÃ¤upl, Caroline Lindau, Audrey Hessel, Yong Wang, Conny SchÃ¼tze, Tobias Jores, Laura Melchionda, Birgit SchÃ¶nfisch, Hubert Kalbacher, Beate Bersch, Doron Rapaport, Martha Brennich, Kresten Lindorff-Larsen, Nils Wiedemann, Paul Schanda Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space published pages: 1365-1379.e25, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.039	Cell 175/5	2020-04-09

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