LIMB NETWORKS SIGNED
Network Analysis of Musculoskeletal Evolution and Modularity during the Fin-to-Limb Transition
Total Cost €
0EC-Contrib. €
0Partnership
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0LIMB NETWORKS project word cloud
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Project "LIMB NETWORKS" data sheet
The following table provides information about the project.
| Coordinator |
THE ROYAL VETERINARY COLLEGE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | https://osf.io/uqtf8/ |
| Total cost | 251˙857 € |
| EC max contribution | 251˙857 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-08-15 to 2018-08-14 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE ROYAL VETERINARY COLLEGE | UK (LONDON) | coordinator | 251˙857.00 |
| 2 | howard university | US (Washington) | partner | 0.00 |
Map
Project objective
The fin-to-limb transition was a major milestone in the history of life that shaped the morphology and remarkable biodiversity of land vertebrates. A central question in vertebrate evolution is how the various anatomical parts of limbs evolved semi-autonomously (modularity) while still growing and adapting in coordination (integration). The main goal of this project is to unravel (i) the evolutionary changes in modularity of the musculoskeletal system that occurred during the evolution from fins to limbs and (ii) how these newly acquired modular organizations facilitated the evolution of different morphologies for the forelimb and hindlimb. To this end, we will evaluate the modularity of limbs and the strength of topological integration among modules by using an innovative approach–anatomical network analysis–¬¬based on the topological relations that anatomical parts establish among them; these anatomical relations are embodied in network models and quantified globally using sophisticated algorithms from Graph Theory. We propose a multidisciplinary combination, for the first time, of (i) new data on fin/limb muscle anatomy in extant species, (ii) reconstruction of muscle attachments in extinct forms, and (iii) the use of innovative tools such as Anatomical Network Analysis to identify morphological modules and quantify their integration within a phylogenetic context. The results of this unique and transformative project have the potential to revolutionize our understanding of limb evolution during the fin-limb transition. The training in gross anatomy, imaging techniques, and reconstruction of muscles in fossils by the leading researchers involved in this project will foster the development of the candidate Fellow as an independent and innovative frontline researcher in theoretical, evolutionary, and comparative biology in the EU.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Diego Rasskin-Gutman, Borja Esteve-Altava Concept of Burden in Evo-Devo published pages: 1-11, ISSN: , DOI: 10.1007/978-3-319-33038-9_48-1 |
Evolutionary Developmental Biology | 2019-06-12 |
| 2018 |
Borja Esteve-Altava, Diego Rasskin-Gutman Anatomical network analysis in Evo-Devo published pages: 1-19, ISSN: , DOI: 10.1007/978-3-319-33038-9_57-1 |
Evolutionary Developmental Biology | 2019-06-12 |
| 2017 |
Borja Esteve-Altava Challenges in identifying and interpreting organizational modules in morphology published pages: , ISSN: 0362-2525, DOI: 10.1002/jmor.20690 |
Journal of Morphology | 2019-06-12 |
| 2018 |
Rui Diogo, Julia L. Molnar, Campbell Rolian, Borja Esteve-Altava First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25262-6 |
Scientific Reports 8/1 | 2019-06-12 |
| 2016 |
Rui Diogo, Peter Johnston, Julia L. Molnar, Borja Esteve-Altava Characteristic tetrapod musculoskeletal limb phenotype emerged more than 400 MYA in basal lobe-finned fishes published pages: 37592, ISSN: 2045-2322, DOI: 10.1038/srep37592 |
Scientific Reports 6 | 2019-06-12 |
| 2016 |
Borja Esteve-Altava In search of morphological modules: a systematic review published pages: , ISSN: 1464-7931, DOI: 10.1111/brv.12284 |
Biological Reviews | 2019-06-12 |
| 2018 |
Borja Esteve-Altava, Julia L. Molnar, Peter Johnston, John R. Hutchinson, Rui Diogo Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition published pages: 601-618, ISSN: 0014-3820, DOI: 10.1111/evo.13430 |
Evolution 72/3 | 2019-06-12 |
| 2018 |
Borja Esteve-Altava, Stephanie E Pierce, Julia L Molnar, Peter Johnston, Rui Diogo, John R Hutchinson Evolutionary parallelisms of pectoral and pelvic network-anatomy from fins to limbs published pages: , ISSN: , DOI: 10.1101/374504 |
bioRxiv 374504 | 2019-06-12 |
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