FLUNOVELTY
Development of novel fluorinated reagents for preparation of drugs.
Total Cost €
0EC-Contrib. €
0Partnership
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Project "FLUNOVELTY" data sheet
The following table provides information about the project.
| Coordinator |
ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | https://www.lco.espci.fr/-Prof-Janine-Cossy |
| Total cost | 92˙538 € |
| EC max contribution | 92˙538 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-11-01 to 2016-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS | FR (PARIS) | coordinator | 92˙538.00 |
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Project objective
Around 20% of all modern drugs are fluorinated organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical reagents and reactions towards “drug-like” compounds. In this project, we will address this issue by discovering novel small fluorinating reagents - fluorinated diazoalkanes, - elaborate their practical reactions, and use this knowledge to develop alternative synthetic approaches to some known drugs (AS-136A, Celecoxib).
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Anton V. Arkhipov, Viatcheslav V. Arkhipov, Janine Cossy, Volodymir O. Kovtunenko, Pavel K. Mykhailiuk Unexpected Reactivity of Trifluoromethyl Diazomethane (CF 3 CHN 2 ): Electrophilicity of the Terminal N-Atom published pages: asap, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01565 |
Organic Letters | 2019-07-23 |
| 2016 |
Pavel K. Mykhailiuk, Aleksandr Yu. Ishchenko, Viatcheslav Stepanenko, Janine Cossy Synthesis of Fluoroalkyl Pyrazoles from In-Situ-Generated C 2 F 5 CHN 2 and Electron-Deficient Alkenes published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201600947 |
European Journal of Organic Chemistry | 2019-07-23 |
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