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BlaC E-assay

Portable electrochemical assay system for on-chip quantitative estimation of bladder cancer biomarkers in real samples

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BlaC E-assay project word cloud

Explore the words cloud of the BlaC E-assay project. It provides you a very rough idea of what is the project "BlaC E-assay" about.

worldwide multiplexed bench rate detection shelf elisa biomarker cancer life successful poc separation samples prototype care clinical assay multiple sensors gwent operation accuracy urgent volume optical innovative compact death laborious surface detect optimization solutions technologies signals point multidisciplinary specificity meets group time size survival sensitive bladder sensor enzyme diagnose panel mainly commercially selectivity diagnostic chemistry stage chamber platforms publications techniques electrochemistry promise sensitivity secondment clinically microfluidic device background biomarkers individuals industrial screening mentioned rapid ip consuming model explosion suffer electrochemical outcome simultaneously risk ltd standards

Project "BlaC E-assay" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF BATH Organization address address: CLAVERTON DOWN city: BATH postcode: BA2 7AY website: http://www.bath.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://go.bath.ac.uk/biosensors
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-05 to 2017-10-04

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF BATH UNIVERSITY OF BATH Organization address address: CLAVERTON DOWN city: BATH postcode: BA2 7AY website: http://www.bath.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BATH)	coordinator	195˙454.00

Map

Project objective

Cancer is a leading cause of death worldwide and the best approaches to improve cancer survival rate is to diagnose it at an early stage. In spite of the rapid explosion of new technology platforms, traditional optical ELISA is used in clinical practice, which is laborious, time-consuming, require large sample volume and suffer from low sensitivity. On the other hand, recently proposed electrochemical sensors which promise easy operation, accuracy, high sensitivity, low cost and compact size mainly suffer from background signals, non-specificity and selectivity in clinical samples. Therefore, there is an urgent need to solve the key issues in the development of clinically relevant and commercially viable technologies that enable screening of high-risk individuals for cancer at an early stage. The proposed program is to develop a reliable point-of-care (POC) diagnostic system based on a multidisciplinary approach of integrated microfluidic and electrochemistry for multiple biomarker detection in clinical samples. The proposal aims at finding solutions for key issues of non-specificity, sensitivity and selectivity in clinical samples for sensitive and multiplexed detection. The proposal will address the above mentioned challenges, via separation of assay chamber and detection chamber with innovative surface chemistry and microfluidic design with electrochemical detection techniques. Work will be focused on bladder cancer as a test model to solve the above mentioned issues. The proposed device will be of bench top size and have capabilities to detect a panel of 3 or more biomarkers simultaneously. The successful outcome of the project will result in high impact publications, technology know-how and IP, which will be used to design and develop a prototype device. A secondment at Applied Enzyme Technology Ltd, Gwent Group (GWENT) will be used to study optimization of sensor shelf life and to ensure the developed system meets industrial standards.

Publications

List of publications.
year	authors and title	journal	last update
2018	Sunil K. Arya, Pedro Estrela Electrochemical ELISA-based platform for bladder cancer protein biomarker detection in urine published pages: 620-627, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.07.003	Biosensors and Bioelectronics 117	2019-06-13
2018	Pavel Zhurauski, Sunil K. Arya, Pawan Jolly, Christian Tiede, Darren C. Tomlinson, Paul Ko Ferrigno, Pedro Estrela Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection published pages: 1-8, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.02.041	Biosensors and Bioelectronics 108	2019-06-13
2018	Naveen K. Singh, Sunil K. Arya, Pedro Estrela, Pranab Goswami Capacitive malaria aptasensor using Plasmodium falciparum glutamate dehydrogenase as target antigen in undiluted human serum published pages: 246-252, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.06.022	Biosensors and Bioelectronics 117	2019-06-13
2018	Sunil Arya, Pedro Estrela Recent Advances in Enhancement Strategies for Electrochemical ELISA-Based Immunoassays for Cancer Biomarker Detection published pages: 2010, ISSN: 1424-8220, DOI: 10.3390/s18072010	Sensors 18/7	2019-06-13
2018	Sunil K. Arya, Pavel Zhurauski, Pawan Jolly, Marina R. Batistuti, Marcelo Mulato, Pedro Estrela Capacitive aptasensor based on interdigitated electrode for breast cancer detection in undiluted human serum published pages: 106-112, ISSN: 0956-5663, DOI: 10.1016/j.bios.2017.11.013	Biosensors and Bioelectronics 102	2019-06-13
2017	Sunil K. Arya, Pedro Estrela Electrochemical immunosensor for tumor necrosis factor-alpha detection in undiluted serum published pages: 125-131, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2016.12.001	Methods 116	2019-06-13

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