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AuxinER SIGNED

Mechanisms of Auxin-dependent Signaling in the Endoplasmic Reticulum

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EC-Contrib. €

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 AuxinER project word cloud

Explore the words cloud of the AuxinER project. It provides you a very rough idea of what is the project "AuxinER" about.

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Project "AuxinER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET FUER BODENKULTUR WIEN 

Organization address
address: GREGOR MENDEL STRASSE 33
city: WIEN
postcode: 1180
website: www.boku.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://www.dagz.boku.ac.at/en/pgz/kleine-vehn/
 Total cost 1˙441˙125 €
 EC max contribution 1˙441˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET FUER BODENKULTUR WIEN AT (WIEN) coordinator 1˙441˙125.00

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 Project objective

The phytohormone auxin has profound importance for plant development. The extracellular AUXIN BINDING PROTEIN1 (ABP1) and the nuclear AUXIN F-BOX PROTEINs (TIR1/AFBs) auxin receptors perceive fast, non-genomic and slow, genomic auxin responses, respectively. Despite the fact that ABP1 mainly localizes to the endoplasmic reticulum (ER), until now it has been proposed to be active only in the extracellular matrix (reviewed in Sauer and Kleine-Vehn, 2011). Just recently, ABP1 function was also linked to genomic responses, modulating TIR1/AFB-dependent processes (Tromas et al., 2013). Intriguingly, the genomic effect of ABP1 appears to be at least partially independent of the endogenous auxin indole 3-acetic acid (IAA) (Paque et al., 2014). In this proposal my main research objective is to unravel the importance of the ER for genomic auxin responses. The PIN-LIKES (PILS) putative carriers for auxinic compounds also localize to the ER and determine the cellular sensitivity to auxin. PILS5 gain-of-function reduces canonical auxin signaling (Barbez et al., 2012) and phenocopies abp1 knock down lines (Barbez et al., 2012, Paque et al., 2014). Accordingly, a PILS-dependent substrate could be a negative regulator of ABP1 function in the ER. Based on our unpublished data, an IAA metabolite could play a role in ABP1-dependent processes in the ER, possibly providing feedback on the canonical nuclear IAA-signaling. I hypothesize that the genomic auxin response may be an integration of auxin- and auxin-metabolite-dependent nuclear and ER localized signaling, respectively. This proposed project aims to characterize a novel auxin-signaling paradigm in plants. We will employ state of the art interdisciplinary (biochemical, biophysical, computational modeling, molecular, and genetic) methods to assess the projected research. The identification of the proposed auxin conjugate-dependent signal could have far reaching plant developmental and biotechnological importance.

 Publications

year authors and title journal last update
List of publications.
2018 Chloé Béziat, Jürgen Kleine-Vehn
The Road to Auxin-Dependent Growth Repression and Promotion in Apical Hooks
published pages: R519-R525, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.01.069
Current Biology 28/8 2020-02-04
2019 Michael Sauer, Jürgen Kleine-Vehn
PIN-FORMED and PIN-LIKES auxin transport facilitators
published pages: dev168088, ISSN: 0950-1991, DOI: 10.1242/dev.168088
Development 146/15 2020-02-04
2019 Elena Feraru, Mugurel I. Feraru, Elke Barbez, Sascha Waidmann, Lin Sun, Angelika Gaidora, Jürgen Kleine-Vehn
PILS6 is a temperature-sensitive regulator of nuclear auxin input and organ growth in Arabidopsis thaliana
published pages: 3893-3898, ISSN: 0027-8424, DOI: 10.1073/pnas.1814015116
Proceedings of the National Academy of Sciences 116/9 2020-02-04
2017 Chloé Béziat, Elke Barbez, Mugurel I. Feraru, Doris Lucyshyn, Jürgen Kleine-Vehn
Light triggers PILS-dependent reduction in nuclear auxin signalling for growth transition
published pages: 17105, ISSN: 2055-0278, DOI: 10.1038/nplants.2017.105
Nature Plants 3/8 2019-05-29
2016 Luděk Eyer, Thomas Vain, Barbora Pařízková, Jana Oklestkova, Elke Barbez, Hana Kozubíková, Tomáš Pospíšil, Roksana Wierzbicka, Jürgen Kleine-Vehn, Milan Fránek, Miroslav Strnad, Stéphanie Robert, Ondrej Novak
2,4-D and IAA Amino Acid Conjugates Show Distinct Metabolism in Arabidopsis
published pages: e0159269, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0159269
PLOS ONE 11/7 2019-05-29
2016 Silvia Melina Velasquez, Elke Barbez, Jurgen Kleine-Vehn, Jose Estevez
Auxin and cellular elongation
published pages: pp.01863.2015, ISSN: 0032-0889, DOI: 10.1104/pp.15.01863
Plant Physiology 2019-05-29
2015 Kai Dünser, Jürgen Kleine-Vehn
Differential growth regulation in plants—the acid growth balloon theory
published pages: 55-59, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2015.08.009
Current Opinion in Plant Biology 28 2019-05-29

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