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ProCanEx

Prostate cancer diagnostic assay based on protein kinase activity profiling in exosomes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ProCanEx project word cloud

Explore the words cloud of the ProCanEx project. It provides you a very rough idea of what is the project "ProCanEx" about.

men exosome probes clinical innovation profiling care literature covered stratification kinases deadliest treatment tests practical composition instrument positives usd detection million prostate practicality false healthcare plan 2012 worldwide diagnosed painful decisions business levels measuring sustainability patient newly age sme cancer 17 45 circulating diagnostic prognosis sought market 12 supports diseases totalled discovered innovative altered billion financing debated sources tissue biopsies platform quantitative health screening strategy exosomes technological invasive pca 417 protein licensee 2017 antigen psa specificity 70 scientific performed unnecessary originating diagnosis annually biomarker assay positive europeans combines mainly complementary disease markers diagnostics

Project "ProCanEx" data sheet

The following table provides information about the project.

Coordinator	KINASERA OU Organization address address: UUS 63-55 city: TARTU postcode: 50606 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Estonia [EE]
Project website	http://www.kinasera.com
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-1-2015
Funding Scheme	SME-1
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2015-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KINASERA OU KINASERA OU Organization address address: UUS 63-55 city: TARTU postcode: 50606 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	coordinator	50˙000.00

Map

Project objective

The objective of the innovation project is the development of novel biomarker-based non-invasive assay for prostate cancer (PCa) detection. 417 000 Europeans were diagnosed with PCa in 2012, about 12% of all new cancer cases of European men. The diagnosis and screening of PCa totalled 12 billion USD in 2012 and will reach 17.4 billion USD in 2017 since the PSA test is performed for men over 50 years of age annually. The PCa diagnostics market is mainly covered by the Prostate-Specific Antigen (PSA) test, the practicality of which is debated. The low specificity of the test means a high number of false positives, leading to unnecessary and painful procedures (biopsies, treatment, etc.). More than 45 million PSA tests are performed annually worldwide, while more than 9 million of those are positive, with around 70% false positives. Our assay is built on an innovative technological platform based on quantitative profiling of protein kinases in circulating exosomes. Recent scientific literature supports the potential of exosomes as diagnostic markers. Our assay combines two innovative approaches - newly discovered changes in exosome composition in cancer and probes for measuring altered levels of several protein kinases in exosomes originating from the cancer tissue. We will use the phase I of the SME instrument to make a detailed business plan, market research and evaluate technological, technical and practical issues. Collaboration with a potential licensee and complementary sources of financing for Phase II are sought. A detailed research plan will be conducted. Cancer diagnostics is among the main concerns for healthcare as cancer is among the deadliest diseases. Our proposal aims at development of innovative, non-invasive, highly reliable and cost-effective test for PCa, which would contribute to the sustainability of European health care system. Our strategy will enable patient stratification and/or prognosis of disease leading to the improved clinical decisions.

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The information about "PROCANEX" are provided by the European Opendata Portal: CORDIS opendata.