RENALTRACT SIGNED
Development and disease of the renal tract
Total Cost €
0EC-Contrib. €
0Partnership
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0RENALTRACT project word cloud
Explore the words cloud of the RENALTRACT project. It provides you a very rough idea of what is the project "RENALTRACT" about.
Project "RENALTRACT" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | http://renaltract.eu |
| Total cost | 3˙137˙377 € |
| EC max contribution | 3˙137˙377 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2014 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2019-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 1˙051˙502.00 |
| 2 | UNIVERSITY OF GLASGOW | UK (GLASGOW) | participant | 546˙575.00 |
| 3 | UNIVERSITATSKLINIKUM HEIDELBERG | DE (HEIDELBERG) | participant | 373˙824.00 |
| 4 | THE UNIVERSITY OF MANCHESTER | UK (MANCHESTER) | participant | 273˙287.00 |
| 5 | OULUN YLIOPISTO | FI (OULU) | participant | 269˙145.00 |
| 6 | MEDIZINISCHE HOCHSCHULE HANNOVER | DE (HANNOVER) | participant | 249˙216.00 |
| 7 | MOSAIQUES DIAGNOSTICS GMBH | DE (HANNOVER) | participant | 249˙216.00 |
| 8 | DITABIS DIGITAL BIOMEDICAL IMAGING SYSTEMS AG | DE (PFORZHEIM) | participant | 124˙608.00 |
| 9 | ACQUIFER AG | DE (PFORZHEIM) | participant | 0.00 |
Map
Project objective
The renal tract (kidneys, the ureters, bladder) is a complex organ system crucial for maintaining the body homeostasis. This organ system arises from different precursor pools through a complex program of patterning, differentiation and morphogenesis in embryonic development. Alteration of this program leads to renal tract malformations (RTM) that are incompatible with a healthy life. While some of these RTM can be surgically corrected, others develop into chronic entities that may lead to renal failure; the burden for the patients and for the socio-economic impact for the health systems is immense. Although congenital RTM are amongst the most frequent human birth defects, the different programs that direct normal and pathological development have remained poorly understood. The RENALTRACT training network aims to address these deficits and provide a better understanding of the programs that underlie RTM and provide solutions to clinical problems. This shall be achieved by using a multidisciplinary team approach with partners working in complementary disciplines (developmental biology, renal physiology, Omics, clinical medicine). RENALTRACT has unique and distinguishing features by uniting studies on components of the urinary tract, by building a bridge between basic and clinician scientists and by combining state of the art methods from a number of complementary fields in a variety of animal models. RENALTRACT aims to establish a first class multidisciplinary training program for outstanding Early-Stage Researchers (ESRs) to provide a group of young scientists with expert knowledge to envision and embark on novel therapies of renal tract malformations in the future. ESRs will benefit from an excellent working environment with state-of-the-art technologies and supervision by international leaders in the field and an inter-disciplinary approach. This will be complemented by intersectoral exposure and exchange between the RENALTRACT public and private participants.
Deliverables
| Phenotypic characterisation of Phf19 knockout mice | Documents, reports | 2019-11-15 11:18:15 |
| RENALTRACT international symposium | Other | 2019-11-15 11:17:53 |
| List of genes involved in regulation of nephrogenesis induction | Documents, reports | 2019-11-15 11:17:02 |
| Award of doctoral degrees | Documents, reports | 2019-11-15 11:18:18 |
| Functional characterisation of novel genes for kidney and ureter development | Documents, reports | 2019-11-15 11:18:16 |
| Characterization of the regulatory network required for the different steps of the ureteric myogenic program | Documents, reports | 2019-11-15 11:17:02 |
| Role of pax8 targets in the Xenopus kidney | Documents, reports | 2019-11-15 11:18:28 |
| Characterization of the regulatory network required for the progression of the ureteric myogenic program | Documents, reports | 2019-11-15 11:17:01 |
| Establishment of bioinformatic model of kidney development | Documents, reports | 2019-11-15 11:17:01 |
| Phenotypic characterisation of urofacial syndrome mutant mouse renal tracts and hindguts | Documents, reports | 2019-11-15 11:17:51 |
| In vivo functional characterisation of selected miRNAs and the identification of mRNA-feedback loops | Documents, reports | 2019-11-15 11:17:59 |
| Screen and metabolomics analysis for genes for nephrolithiasis and IEM diseases | Documents, reports | 2019-11-15 11:17:49 |
| List of RTM-related peptide biomarkers in urine | Documents, reports | 2019-09-06 08:43:39 |
| Two “Young Researcher Training Workshops†| Other | 2019-09-06 08:43:39 |
| Periodic report | Documents, reports | 2019-09-06 08:43:39 |
| Outreach activities | Other | 2019-09-06 08:43:39 |
| Ethics | Documents, reports | 2019-09-06 08:43:39 |
| Mid-term review Meeting | Documents, reports | 2019-09-06 08:43:39 |
| Supervisory Board of Network | Documents, reports | 2019-09-06 08:43:39 |
| Progress Report | Documents, reports | 2019-09-06 08:43:39 |
| List of novel genetic vari-ants causing maldevelopment of human lower urinary tract | Documents, reports | 2019-09-06 08:43:39 |
| Identification of target genes of Tgfrb-, Pdgfra and/or retinoic acid-signalling in the ureter | Documents, reports | 2019-09-06 08:43:39 |
| Positions’ advertisement | Other | 2019-09-06 08:43:39 |
Take a look to the deliverables list in detail: detailed list of RENALTRACT deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Sunder Sims-Lucas, Misty Good, Seppo J. Vainio Editorial: Organogenesis: From Development to Disease published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2017.00085 |
Frontiers in Cell and Developmental Biology 5 | 2019-10-29 |
| 2019 |
Saurav Ghimire, Selim Terhzaz, Pablo Cabrero, Michael F. Romero, Shireen Davies, Julian A.T. Dow Targeted renal knockdown of Na + /H + exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila published pages: , ISSN: 1931-857X, DOI: 10.1152/ajprenal.00551.2018 |
American Journal of Physiology-Renal Physiology | 2019-10-01 |
| 2019 |
Adrian S. Woolf, Filipa M. Lopes, Parisa Ranjzad, Neil A. Roberts Congenital Disorders of the Human Urinary Tract: Recent Insights From Genetic and Molecular Studies published pages: , ISSN: 2296-2360, DOI: 10.3389/fped.2019.00136 |
Frontiers in Pediatrics 7 | 2019-09-06 |
| 2018 |
Zenglai Tan, Jingdong Shan, Aleksandra Rak-Raszewska, Seppo J. Vainio Embryonic Stem Cells Derived Kidney Organoids as Faithful Models to Target Programmed Nephrogenesis published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34995-3 |
Scientific Reports 8/1 | 2019-09-06 |
| 2019 |
Neil A. Roberts, Emma N. Hilton, Filipa M. Lopes, Subir Singh, Michael J. Randles, Natalie J. Gardiner, Karl Chopra, Riccardo Coletta, Zunera Bajwa, Robert J. Hall, Wyatt W. Yue, Franz Schaefer, Stefanie Weber, Roger Henriksson, Helen M. Stuart, HÃ¥kan Hedman, William G. Newman, Adrian S. Woolf Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder published pages: 1138-1152, ISSN: 0085-2538, DOI: 10.1016/j.kint.2018.11.040 |
Kidney International 95/5 | 2019-09-06 |
| 2019 |
Pierbruno Ricci, Pedro Magalhães, Magdalena Krochmal, Martin Pejchinovski, Erica Daina, Maria Rosa Caruso, Laura Goea, Iwona Belczacka, Giuseppe Remuzzi, Muriel Umbhauer, Jens Drube, Lars Pape, Harald Mischak, Stéphane Decramer, Franz Schaefer, Joost P. Schanstra, Silvia Cereghini, Petra Zürbig Urinary proteome signature of Renal Cysts and Diabetes syndrome in children published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-38713-5 |
Scientific Reports 9/1 | 2019-09-06 |
| 2018 |
Pedro Magalhães, Claudia Pontillo, Martin Pejchinovski, Justyna Siwy, Magdalena Krochmal, Manousos Makridakis, Emma Carrick, Julie Klein, William Mullen, Joachim Jankowski, Antonia Vlahou, Harald Mischak, Joost P. Schanstra, Petra Zürbig, Lars Pape Comparison of Urine and Plasma Peptidome Indicates Selectivity in Renal Peptide Handling published pages: 1700163, ISSN: 1862-8346, DOI: 10.1002/prca.201700163 |
PROTEOMICS - Clinical Applications 12/5 | 2019-09-06 |
| 2018 |
Yasmine Neirijnck, Antoine Reginensi, Kirsten Y. Renkema, Filippo Massa, Vladimir M. Kozlov, Haroun Dhib, Ernie M.H.F. Bongers, Wout F. Feitz, Albertien M. van Eerde, Veronique Lefebvre, Nine V.A.M. Knoers, Mansoureh Tabatabaei, Herbert Schulz, Helen McNeill, Franz Schaefer, Michael Wegner, Elisabeth Sock, Andreas Schedl Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT) published pages: 1142-1153, ISSN: 0085-2538, DOI: 10.1016/j.kint.2017.11.026 |
Kidney International 93/5 | 2019-09-06 |
| 2017 |
Pedro Magalhães, Martin Pejchinovski, Katerina Markoska, Miroslaw Banasik, Marian Klinger, Dominika Å vec-Billá, Ivan RychlÃk, Merita Rroji, Arianna Restivo, Giovambattista Capasso, Flaviu Bob, Adalbert Schiller, Alberto Ortiz, Maria Vanessa Perez-Gomez, Pablo Cannata, Maria Dolores Sanchez-Niño, Radomir Naumovic, Voin Brkovic, Momir Polenakovic, William Mullen, Antonia Vlahou, Petra Zürbig, Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies? published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-17083-w |
Scientific Reports 7/1 | 2019-09-06 |
| 2019 |
Guillermo MartÃnez-Corrales, Pablo Cabrero, Julian A. T. Dow, Selim Terhzaz, Shireen-A. Davies Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule published pages: dev178087, ISSN: 0950-1991, DOI: 10.1242/dev.178087 |
Development 146/9 | 2019-09-06 |
| 2017 |
Magdalena Krochmal, Georgia Kontostathi, Pedro Magalhães, Manousos Makridakis, Julie Klein, Holger Husi, Johannes Leierer, Gert Mayer, Jean-Loup Bascands, Colette Denis, Jerome Zoidakis, Petra Zürbig, Christian Delles, Joost P. Schanstra, Harald Mischak, Antonia Vlahou Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-15359-9 |
Scientific Reports 7/1 | 2019-09-06 |
| 2019 |
L. Pelander, V. Brunchault, B. Buffin-Meyer, J. Klein, B. Breuil, P. Zürbig, P. Magalhães, W. Mullen, J. Elliott, H. Syme, J.P. Schanstra, J. Häggström, I. Ljungvall Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs published pages: 73-79, ISSN: 1090-0233, DOI: 10.1016/j.tvjl.2019.05.010 |
The Veterinary Journal 249 | 2019-09-06 |
| 2019 |
Gunjan Pandey, Jens Westhoff, Franz Schaefer, Jochen Gehrig A Smart Imaging Workflow for Organ-Specific Screening in a Cystic Kidney Zebrafish Disease Model published pages: 1290, ISSN: 1422-0067, DOI: 10.3390/ijms20061290 |
International Journal of Molecular Sciences 20/6 | 2019-09-06 |
| 2016 |
Pedro Magalhães, Harald Mischak, Petra Zürbig Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases published pages: 494-501, ISSN: 1062-4821, DOI: 10.1097/MNH.0000000000000278 |
Current Opinion in Nephrology and Hypertension 25/6 | 2019-09-06 |
| 2016 |
Pedro Magalhães, Joost P. Schanstra, Emma Carrick, Harald Mischak, Petra Zürbig Urinary biomarkers for renal tract malformations published pages: 1121-1129, ISSN: 1478-9450, DOI: 10.1080/14789450.2016.1254555 |
Expert Review of Proteomics 13/12 | 2019-09-06 |
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