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NanoCytox SIGNED

Development of Novel Analytical Methods to assess Nanoparticle cytotoxicity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NanoCytox project word cloud

Explore the words cloud of the NanoCytox project. It provides you a very rough idea of what is the project "NanoCytox" about.

powerful mass incubation physico revealed elucidate natural prior micro insights human methodology droplet coupled detection dg validated experiments materials matrices metallic give goods cell electronics medical resolved generator detect laser responsible plasma toxicological analytical cells model selective therapeutics introduction single nanoparticles particles spectrometry ms ablation la hampered interactions diagnostics nanoparticle limited consists environment sensitive implications inductively attractive energy employed bioimaging medicine harmful toxicity icp nano sensitivity assays herein nps chemical health

Project "NanoCytox" data sheet

The following table provides information about the project.

Coordinator	BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG Organization address address: Unter den Eichen 87 city: BERLIN postcode: 12205 website: www.bam.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.researchgate.net/project/Development-of-Novel-Analytical-Methods-to-Assess-Nanoparticle-Cytotoxicity
Total cost	159˙460 €
EC max contribution	159˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2017-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG Organization address address: Unter den Eichen 87 city: BERLIN postcode: 12205 website: www.bam.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	coordinator	159˙460.00

Map

Project objective

Nanoparticles , NPs, are being used to produce novel materials with unique physico-chemical properties with many applications in fields such as medicine, energy and electronics, consumer goods, among others. Some studies have revealed that the same specific properties that make NPs so unique could also be responsible for potential harmful effects on the environment and human health. Currently, the assessment of their impact is hampered by limited analytical capabilities to detect them in complex natural matrices. New sensitive and selective analytical methods must be developed and validated in order to elucidate their toxicological effects prior to increasing and promoting the NPs production. Herein, new analytical methodologies based on inductively coupled plasma mass spectrometry (ICP-MS) are proposed to evaluate the toxicity of metallic NPs in cells, one of the most powerful and attractive model systems for toxicological assays. The proposed methodology consists on the use of laser ablation (LA) coupled to ICP-MS for spatially resolved bioimaging of the distribution of NPs in single cells upon different NPs incubation experiments; furthermore, a micro-droplet generator (µDG) for sample introduction of single cells into a sector field ICP-MS will be employed to improve the NPs detection sensitivity. The expected results will give essential insights into nanoparticle/cell interactions and will have implications for the development of analytical methods based on applications of nano-particles for medical diagnostics and therapeutics.

Publications

List of publications.
year	authors and title	journal	last update
2017	Erik Guehrs, Michael Schneider, Christian M. GÃ¼nther, Piet Hessing, Karen Heitz, Doreen Wittke, Ana LÃ³pez-Serrano Oliver, Norbert Jakubowski, Johanna Plendl, Stefan Eisebitt, Andrea Haase Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and view published pages: , ISSN: 1477-3155, DOI: 10.1186/s12951-017-0255-8	Journal of Nanobiotechnology 15/1	2019-06-13
2018	S. Meyer, A. LÃ³pez-Serrano, H. Mitze, N. Jakubowski, T. Schwerdtle Single-cell analysis by ICP-MS/MS as a fast tool for cellular bioavailability studies of arsenite published pages: 73-76, ISSN: 1756-5901, DOI: 10.1039/C7MT00285H	Metallomics 10/1	2019-06-13
2018	Ana LÃ³pez-Serrano, Sabine Baumgart, Wolfram Bremser, Sabine Flemig, Doreen Wittke, Andreas Gruetzkau, Andreas Luch, Andrea Haase, Norbert Jakubowski Quantification of silver nanoparticles up-taken by single cells using inductively coupled plasma mass spectrometry in the single cell measurement mode published pages: , ISSN: 0267-9477, DOI: 10.1039/C7JA00395A	Journal of Analytical Atomic Spectrometry	2019-06-13

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