Explore the words cloud of the OxygenSensing project. It provides you a very rough idea of what is the project "OxygenSensing" about.
The following table provides information about the project.
Coordinator |
UNIVERSIDAD DE SEVILLA
Organization address contact info |
Coordinator Country | Spain [ES] |
Project website | https://www.ibis-sevilla.es/investigacion/neurociencias/neurobiologia-celular-y-biofisica/lopez-barneo-jose.aspx |
Total cost | 2˙843˙750 € |
EC max contribution | 2˙843˙750 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-ADG |
Funding Scheme | ERC-ADG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-11-01 to 2020-10-31 |
Take a look of project's partnership.
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1 | UNIVERSIDAD DE SEVILLA | ES (SEVILLA) | coordinator | 2˙843˙750.00 |
Oxygen (O2) is essential for life on Earth. This proposal deals with the study of the molecular mechanisms underlying acute O2 sensing by cells, a long-standing issue that is yet to be elucidated. In recent years, the discovery of hypoxia inducible transcription factors and their regulation by the O2-dependent hydroxylases has provided a solid framework for understanding genetic responses to sustained (chronic) hypoxia. However the mechanisms of acute O2 sensing, necessary for the activation of rapid, life-saving, compensatory respiratory and cardiovascular reflexes (e.g. hyperventilation and sympathetic activation), are unknown. While the primary goal of the project is to characterize the molecular mechanisms underlying acute O2 sensing by arterial chemoreceptors (carotid body –CB- and adrenal medulla –AM-), we will also extend our study to other organs (e.g. pulmonary and systemic arteries) of the homeostatic acute O2-sensing system. We will investigate the role of mitochondria, in particular complex I (MCI), in acute O2 sensing. Previous data from our group demonstrated that rotenone, a MCI blocker, selectively occludes responsiveness to hypoxia in CB cells. In addition, our unpublished data indicate that sensitivity to hypoxia (but not to other stimuli) is lost in mice with genetic disruption of MCI genes in CB and AM cells. We have shown that the adult CB is a plastic organ that contains a population of multipotent neural stem cells. Hence, another objective of the project is to study the role of these stem cells in CB modulation (over- or infra-activation), which may participate in the pathogenesis of diseases. In the past, our group has made seminal contributions to unveiling the cellular bases of arterial chemoreception. The discovery of stem cells in the CB and the generation of new genetically modified mouse models, put us in a leading position to elucidate the molecular bases of acute O2 sensing and their biomedical implications.
year | authors and title | journal | last update |
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2018 |
Ignacio Arias-Mayenco, Patricia González-RodrÃguez, Hortensia Torres-Torrelo, Lin Gao, M. Carmen Fernández-Agüera, Victoria Bonilla-Henao, Patricia Ortega-Sáenz, José López-Barneo Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization published pages: 145-158.e4, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.05.009 |
Cell Metabolism 28/1 | 2019-07-04 |
2015 |
M. Carmen Fernández-Agüera, Lin Gao, Patricia González-RodrÃguez, C. Oscar Pintado, Ignacio Arias-Mayenco, Paula GarcÃa-Flores, Antonio GarcÃa-Pergañeda, Alberto Pascual, Patricia Ortega-Sáenz, José López-Barneo Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling published pages: 825-837, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2015.09.004 |
Cell Metabolism 22/5 | 2019-07-04 |
2016 |
Patricia Ortega-Sáenz, David MacÃas, Konstantin L. Levitsky, José A. RodrÃguez-Gómez, Patricia González-RodrÃguez, Victoria Bonilla-Henao, Ignacio Arias-Mayenco, José López-Barneo Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion published pages: 7229-7248, ISSN: 0022-3751, DOI: 10.1113/JP272961 |
The Journal of Physiology 594/24 | 2019-07-04 |
2018 |
David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo, Randall S Johnson HIF-2α is essential for carotid body development and function published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.34681 |
eLife 7 | 2019-07-04 |
2018 |
Verónica Sobrino, Patricia Gonzálezâ€RodrÃguez, Valentina Annese, José Lópezâ€Barneo, Ricardo Pardal Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia published pages: e44598, ISSN: 1469-221X, DOI: 10.15252/embr.201744598 |
EMBO reports 19/3 | 2019-07-04 |
2017 |
Lin Gao, Patricia González-RodrÃguez, Patricia Ortega-Sáenz, José López-Barneo Redox signaling in acute oxygen sensing published pages: 908-915, ISSN: 2213-2317, DOI: 10.1016/j.redox.2017.04.033 |
Redox Biology 12 | 2019-07-04 |
2017 |
Lin Gao, Victoria Bonilla-Henao, Paula GarcÃa-Flores, Ignacio Arias-Mayenco, Patricia Ortega-Sáenz, José López-Barneo Gene expression analyses reveal metabolic specifications in acute O 2 -sensing chemoreceptor cells published pages: 6091-6120, ISSN: 0022-3751, DOI: 10.1113/JP274684 |
The Journal of Physiology 595/18 | 2019-07-04 |
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