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MSmed SIGNED
Mass spectrometric technology for next generation proteomics in systems medicine
Total Cost €
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0MSmed project word cloud
Explore the words cloud of the MSmed project. It provides you a very rough idea of what is the project "MSmed" about.
expression
elucidations
workflows
contexts
spectrometry
advancing
fluids
technologies
industrial
diagnosis
genomic
mass
ten
performance
record
proteome
strength
biologically
drug
quantify
breakthroughs
isoforms
routinely
action
machine
sequencing
learning
tissues
eco
turn
academia
medicine
throughput
laboratory
patient
frag
automated
applicants
improvement
tionize
community
revolu
instrumentation
myriad
basis
urgent
leaders
systems
global
identification
oriented
human
cells
biological
bling
ena
breakthrough
designates
levels
enrichment
vision
body
biomedicine
workflow
area
platforms
not
health
generation
clinic
data
organoids
representative
clinical
pioneering
omic
disease
proteins
mined
gene
track
industry
protein
prognosis
merged
multiplexed
powerful
multidimensional
profiling
modifications
mentation
separation
spectrometric
larger
generate
proteomics
mechanisms
made
ready
Project "MSmed" data sheet
The following table provides information about the project.
| Coordinator |
KOBENHAVNS UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Project website | http://www.nowebsite.none |
| Total cost | 5˙038˙875 € |
| EC max contribution | 3˙672˙625 € (73%) |
| Programme |
1. H2020-EU.1.2.1. (FET Open) |
| Code Call | H2020-FETOPEN-2014-2015-RIA |
| Funding Scheme | RIA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-12-01 to 2019-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KOBENHAVNS UNIVERSITET | DK (KOBENHAVN) | coordinator | 1˙403˙600.00 |
| 2 | THERMO FISHER SCIENTIFIC (BREMEN) GMBH | DE (BREMEN) | participant | 870˙000.00 |
| 3 | UNIVERSITEIT UTRECHT | NL (UTRECHT) | participant | 700˙000.00 |
| 4 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (MUENCHEN) | participant | 699˙025.00 |
Map
Project objective
Systems medicine designates the application of global approaches to human health and disease. Genomic technologies, especially next-generation sequencing, are already pioneering this new area. There is an urgent need to advance proteomics technologies to a similar level. This will help revolu¬tionize diagnosis and prognosis based on the expression levels and modifications of proteins in cells, tissues, organoids or body fluids. Our vision is to make mass spectrometry so robust and powerful that it will be present in every biological laboratory and in every clinic. The applicants are leaders in proteomics technologies from academia and industry and have an out-standing track-record in advancing both instrumentation as well as its application in biological and disease contexts. Here we come together to develop breakthrough technology capable of more than a factor ten improvement in parameters of performance of the mass spectrometric workflow, ena¬bling patient-oriented proteome profiling. The proteomics workflow will be automated, multiplexed and made ‘industrial strength’ - ready for high-throughput and in-depth clinical applications. Importantly, in addition to the identification of the main protein representative of a gene, we aim to routinely identify and quantify protein modifications and isoforms by using multidimensional approaches, including new separation, enrichment and frag¬mentation technologies. The breakthroughs aimed for will generate larger more biologically relevant data. This data will be merged with other ‘omic’ data and mined using machine learning technologies. Our results will establish the role mass spectrometry in systems medicine, making all workflows and mass spectrometry platforms available to the community. They will be used as the basis of myriad applications in biomedicine, even in the clinic. This in turn will lead to a new eco-system around improved diagnosis, elucidations of disease mechanisms and drug action.
Deliverables
| LCMS time-scale compatible peptide and protein sequencing using hybrid fragmentation methods, with special applications into multiply modified larger peptides | Documents, reports | 2019-05-03 16:53:16 |
| Construction/coupling of UVPD to the latest Orbitrap instruments | Documents, reports | 2019-05-03 16:53:42 |
| Software module for comprehensive identification of PTMs, mutations and splice variants | Documents, reports | 2019-05-03 16:44:40 |
| MaxQuant summer school | Other | 2019-05-03 16:44:41 |
| Industrialized workflow with low CVs | Documents, reports | 2019-05-03 16:44:39 |
| Software module for multiplexed quantification of clinical samples | Documents, reports | 2019-05-07 11:36:07 |
| LCMS time-scale compatible UV-PD peptide and protein sequencing | Documents, reports | 2019-05-07 11:36:08 |
| Robust and reproducible sample prepa¬ration protocols including MS instru¬mentation and acquisition strat-egies for large-scale, quantitative PTM analysis from primary tissue samples such as patient biopsy material | Other | 2019-05-07 11:36:04 |
| Ethics check | Documents, reports | 2019-05-07 11:36:02 |
| Data Management Plan | Other | 2019-05-07 11:36:02 |
Take a look to the deliverables list in detail: detailed list of MSmed deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Clement M. Potel, Miao-Hsia Lin, Nadine Prust, Henk W. P. van den Toorn, Albert J. R. Heck, Simone Lemeer Gaining Confidence in the Elusive Histidine Phosphoproteome published pages: 5542-5547, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b00734 |
Analytical Chemistry 91/9 | 2020-01-30 |
| 2019 |
Jean-François Greisch, Sem Tamara, Richard A. Scheltema, Howard W. R. Maxwell, Robert D. Fagerlund, Peter C. Fineran, Stephan Tetter, Donald Hilvert, Albert J. R. Heck Expanding the mass range for UVPD-based native top-down mass spectrometry published pages: 7163-7171, ISSN: 2041-6520, DOI: 10.1039/c9sc01857c |
Chemical Science 10/30 | 2020-01-30 |
| 2019 |
Marta Murgia, Jing Tan, Philipp E. Geyer, Sophia Doll, Matthias Mann, Thomas Klopstock Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy published pages: 3825-3834.e4, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.11.055 |
Cell Reports 29/12 | 2020-01-29 |
| 2018 |
Miao-Hsia Lin, Clement M. Potel, Kamaleddin H. M. E. Tehrani, Albert J. R. Heck, Nathaniel I. Martin, Simone Lemeer A New Tool to Reveal Bacterial Signaling Mechanisms in Antibiotic Treatment and Resistance published pages: 2496-2507, ISSN: 1535-9476, DOI: 10.1074/mcp.ra118.000880 |
Molecular & Cellular Proteomics 17/12 | 2020-01-29 |
| 2018 |
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei published pages: 2018-2033, ISSN: 1535-9476, DOI: 10.1074/mcp.ra118.000924 |
Molecular & Cellular Proteomics 17/10 | 2020-01-30 |
| 2018 |
Oleg Klykov, Barbara Steigenberger, Sibel PektaÅŸ, Domenico Fasci, Albert J. R. Heck, Richard A. Scheltema Efficient and robust proteome-wide approaches for cross-linking mass spectrometry published pages: 2964-2990, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0074-x |
Nature Protocols 13/12 | 2020-01-30 |
| 2019 |
Tomislav ÄŒaval, Jing Zhu, Albert J.R. Heck Simply Extending the Mass Range in Electron Transfer Higher Energy Collisional Dissociation Increases Confidence in N-Glycopeptide Identification published pages: 10401-10406, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b02125 |
Analytical Chemistry 91/16 | 2020-01-30 |
| 2019 |
Laura C. Demmers, Albert J. R. Heck, Wei Wu Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome published pages: 1634-1643, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00821 |
Journal of Proteome Research 18/4 | 2020-01-30 |
| 2018 |
Karli R. Reiding, Albert Bondt, Vojtech Franc, Albert J.R. Heck The benefits of hybrid fragmentation methods for glycoproteomics published pages: 260-268, ISSN: 0165-9936, DOI: 10.1016/j.trac.2018.09.007 |
TrAC Trends in Analytical Chemistry 108 | 2020-01-29 |
| 2018 |
David Y. Chiang, Katherina M. Alsina, Eleonora Corradini, Martin Fitzpatrick, Li Ni, Satadru K. Lahiri, Julia O. Reynolds, Xiaolu Pan, Larry Scott, Albert J.R. Heck, Xander H.T. Wehrens Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression published pages: 1569-1581, ISSN: 0009-7322, DOI: 10.1161/circulationaha.118.034361 |
Circulation 138/15 | 2020-01-29 |
| 2018 |
Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Alicia Lundby, Shana Claeys, Katleen De Preter, Frank Speleman, Chiara Francavilla, Jesper V. Olsen Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma published pages: eaap9752, ISSN: 1937-9145, DOI: 10.1126/scisignal.aap9752 |
Science Signaling 11/557 | 2020-01-30 |
| 2018 |
Jing Zhu, Luc Garrigues, Henk Van den Toorn, Bernd Stahl, Albert J. R. Heck Discovery and Quantification of Nonhuman Proteins in Human Milk published pages: 225-238, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00550 |
Journal of Proteome Research 18/1 | 2020-01-30 |
| 2019 |
Tanveer S. Batth, Maxim A. X. Tollenaere, Patrick Rüther, Alba Gonzalez-Franquesa, Bhargav S. Prabhakar, Simon Bekker-Jensen, Atul S. Deshmukh, Jesper V. Olsen Protein Aggregation Capture on Microparticles Enables Multipurpose Proteomics Sample Preparation published pages: 1027-1035, ISSN: 1535-9476, DOI: 10.1074/mcp.tir118.001270 |
Molecular & Cellular Proteomics 18/5 | 2020-01-30 |
| 2018 |
Clement M Potel, Miao-Hsia Lin, Albert J R Heck, Simone Lemeer Widespread bacterial protein histidine phosphorylation revealed by mass spectrometry-based proteomics published pages: 187-190, ISSN: 1548-7091, DOI: 10.1038/nmeth.4580 |
Nature Methods 15/3 | 2020-01-30 |
| 2019 |
Hecht, E.S., Scigelova, M., Eliuk, S. and Makarov, A. Fundamentals and Advances of Orbitrap Mass Spectrometry published pages: , ISSN: , DOI: |
Encyclopedia of Analytical Chemistry | 2020-01-29 |
| 2018 |
Sebastiaan C. de Graaf, Oleg Klykov, Henk van den Toorn, Richard A. Scheltema Cross-ID: Analysis and Visualization of Complex XL–MS-Driven Protein Interaction Networks published pages: 642-651, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00725 |
Journal of Proteome Research 18/2 | 2020-01-30 |
| 2019 |
Dorte B. Bekker-Jensen, Oliver M. Bernhardt, Alexander Hogrebe, Ana Martinez del Val, Lynn Verbeke, Tejas Gandhi, Christian D. Kelstrup, Lukas Reiter, Jesper V. Olsen Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition (DIA) without the need for spectral libraries published pages: , ISSN: , DOI: 10.1101/657858 |
bioRxiv | 2020-01-30 |
| 2019 |
Dorte B. Bekker-Jensen, Ana MartÃnez del Val, Sophia Steigerwald, Patrick Rüther, Kyle Fort, Tabiwang N. Arrey, Alexander Harder, Alexander Makarov, Jesper V. Olsen A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients published pages: , ISSN: , DOI: 10.1101/860643 |
bioRxiv | 2020-01-30 |
| 2018 |
Clement M. Potel, Simone Lemeer, Albert J. R. Heck Phosphopeptide Fragmentation and Site Localization by Mass Spectrometry: An Update published pages: 126-141, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b04746 |
Analytical Chemistry 91/1 | 2020-01-30 |
| 2019 |
Kelly A. Dingess, Henk W. P. van den Toorn, Marko Mank, Bernd Stahl, Albert J. R. Heck Toward an efficient workflow for the analysis of the human milk peptidome published pages: 1351-1363, ISSN: 1618-2642, DOI: 10.1007/s00216-018-01566-4 |
Analytical and Bioanalytical Chemistry 411/7 | 2020-01-30 |
| 2018 |
Vyacheslav Akimov, Inigo Barrio-Hernandez, Sten V. F. Hansen, Philip Hallenborg, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Michele Puglia, Stine D. K. Christensen, Jens T. Vanselow, Mogens M. Nielsen, Irina Kratchmarova, Christian D. Kelstrup, Jesper V. Olsen, Blagoy Blagoev UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites published pages: 631-640, ISSN: 1545-9993, DOI: 10.1038/s41594-018-0084-y |
Nature Structural & Molecular Biology 25/7 | 2020-01-30 |
| 2019 |
Tomislav ÄŒaval, Jing Zhu, Weihua Tian, Sanne Remmelzwaal, Zhang Yang, Henrik Clausen, Albert J.R. Heck Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification published pages: 16-27, ISSN: 1535-9476, DOI: 10.1074/mcp.ra118.000967 |
Molecular & Cellular Proteomics 18/1 | 2020-01-30 |
| 2018 |
Clement M. Potel, Domenico Fasci, Albert J.R. Heck Mix and match of the tumor metastasis suppressor Nm23 protein isoforms in vitro and in vivo published pages: 2856-2868, ISSN: 1742-464X, DOI: 10.1111/febs.14525 |
The FEBS Journal 285/15 | 2020-01-29 |
| 2019 |
Christoph Wichmann, Florian Meier, Sebastian Virreira Winter, Andreas-David Brunner, Jürgen Cox, Matthias Mann MaxQuant.Live Enables Global Targeting of More Than 25,000 Peptides published pages: 982-994, ISSN: 1535-9476, DOI: 10.1074/mcp.tir118.001131 |
Molecular & Cellular Proteomics 18/5 | 2020-01-30 |
| 2019 |
Barbara Steigenberger, Roland J. Pieters, Albert J. R. Heck, Richard A. Scheltema PhoX: An IMAC-Enrichable Cross-Linking Reagent published pages: 1514-1522, ISSN: 2374-7943, DOI: 10.1021/acscentsci.9b00416 |
ACS Central Science 5/9 | 2020-01-30 |
| 2017 |
Miia R. Mäkelä, Ourdia Bouzid, Diogo Robl, Harm Post, Mao Peng, Albert Heck, Maarten Altelaar, Ronald P. de Vries Cultivation of Podospora anserina on soybean hulls results in an efficient enzyme cocktail for plant biomass hydrolysis published pages: 162-171, ISSN: 1871-6784, DOI: 10.1016/j.nbt.2017.02.002 |
New Biotechnology 37 | 2020-01-30 |
| 2019 |
Philipp E Geyer, Eugenia Voytik, Peter V Treit, Sophia Doll, Alisa Kleinhempel, Lili Niu, Johannes B Müller, Marieâ€Luise Buchholtz, Jakob M Bader, Daniel Teupser, Lesca M Holdt, Matthias Mann Plasma Proteome Profiling to detect and avoid sampleâ€related biases in biomarker studies published pages: e10427, ISSN: 1757-4676, DOI: 10.15252/emmm.201910427 |
EMBO Molecular Medicine 11/11 | 2020-01-30 |
| 2019 |
Andrey Dyachenko, Sem Tamara, Albert J. R. Heck Distinct Stabilities of the Structurally Homologous Heptameric Co-Chaperonins GroES and gp31 published pages: 7-15, ISSN: 1044-0305, DOI: 10.1007/s13361-018-1910-5 |
Journal of The American Society for Mass Spectrometry 30/1 | 2020-01-30 |
| 2019 |
Alicia Lundby, Giulia Franciosa, Kristina B. Emdal, Jan C. Refsgaard, Sebastian P. Gnosa, Dorte B. Bekker-Jensen, Anna Secher, Svetlana R. Maurya, Indranil Paul, Blanca L. Mendez, Christian D. Kelstrup, Chiara Francavilla, Marie Kveiborg, Guillermo Montoya, Lars J. Jensen, Jesper V. Olsen Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites published pages: 543-560.e26, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.09.008 |
Cell 179/2 | 2020-01-30 |
| 2019 |
Lili Niu, Philipp E Geyer, Nicolai J Wewer Albrechtsen, Lise L Gluud, Alberto Santos, Sophia Doll, Peter V Treit, Jens J Holst, Filip K Knop, Tina Vilsbøll, Anders Junker, Stephan Sachs, Kerstin Stemmer, Timo D Müller, Matthias H Tschöp, Susanna M Hofmann, Matthias Mann Plasma proteome profiling discovers novel proteins associated with nonâ€alcoholic fatty liver disease published pages: e8793, ISSN: 1744-4292, DOI: 10.15252/msb.20188793 |
Molecular Systems Biology 15/3 | 2020-01-30 |
| 2019 |
Fabian Coscia, Sophia Doll, Jacob Mathias Bech, Andreas Mund, Ernst Lengyel, Jan Lindebjerg, Gunvor Iben Madsen, José M. A. Moreira, Matthias Mann A streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis published pages: , ISSN: , DOI: 10.1101/779009 |
bioRxiv | 2020-01-30 |
| 2018 |
Christian D. Kelstrup, Konstantin Aizikov, Tanveer S. Batth, Arne Kreutzman, Dmitry Grinfeld, Oliver Lange, Daniel Mourad, Alexander A. Makarov, Jesper V. Olsen Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution published pages: 4008-4016, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00381 |
Journal of Proteome Research 17/11 | 2020-01-30 |
| 2018 |
Clement M. Potel, Miao-Hsia Lin, Albert J. R. Heck, Simone Lemeer Defeating Major Contaminants in Fe 3+ - Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment published pages: 1028-1034, ISSN: 1535-9476, DOI: 10.1074/mcp.tir117.000518 |
Molecular & Cellular Proteomics 17/5 | 2020-01-29 |
| 2018 |
Yasset Perez-Riverol, Attila Csordas, Jingwen Bai, Manuel Bernal-Llinares, Suresh Hewapathirana, Deepti J Kundu, Avinash Inuganti, Johannes Griss, Gerhard Mayer, Martin Eisenacher, Enrique Pérez, Julian Uszkoreit, Julianus Pfeuffer, Timo Sachsenberg, Åžule Yılmaz, Shivani Tiwary, Jürgen Cox, Enrique Audain, Mathias Walzer, Andrew F Jarnuczak, Tobias Ternent, Alvis Brazma, Juan Antonio VizcaÃno The PRIDE database and related tools and resources in 2019: improving support for quantification data published pages: D442-D450, ISSN: 0305-1048, DOI: 10.1093/nar/gky1106 |
Nucleic Acids Research 47/D1 | 2019-11-25 |
| 2019 |
Jan Daniel Rudolph, Jürgen Cox A Network Module for the Perseus Software for Computational Proteomics Facilitates Proteome Interaction Graph Analysis published pages: 2052-2064, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00927 |
Journal of Proteome Research 18/5 | 2019-11-22 |
| 2018 |
Nicolai Bache, Philipp E. Geyer, Dorte B. Bekker-Jensen, Ole Hoerning, Lasse Falkenby, Peter V. Treit, Sophia Doll, Igor Paron, Johannes B. Müller, Florian Meier, Jesper V. Olsen, Ole Vorm, Matthias Mann A Novel LC System Embeds Analytes in Pre-formed Gradients for Rapid, Ultra-robust Proteomics published pages: 2284-2296, ISSN: 1535-9476, DOI: 10.1074/mcp.TIR118.000853 |
Molecular & Cellular Proteomics 17/11 | 2019-11-22 |
| 2018 |
Jennie R. Lill, Peter A. van Veelen, Stefan Tenzer, Arie Admon, Etienne Caron, Joshua E. Elias, Albert J.R. Heck, Miguel Marcilla, Fabio Marino, Markus Müller, Bjoern Peters, Anthony Purcell, Alessandro Sette, Theo Sturm, Nicola Ternette, Juan Antonio VizcaÃno, Michal Bassani-Sternberg Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE) published pages: 1800110, ISSN: 1615-9853, DOI: 10.1002/pmic.201800110 |
PROTEOMICS 18/12 | 2019-04-30 |
| 2018 |
Nicolai J. Wewer Albrechtsen, Philipp E. Geyer, Sophia Doll, Peter V. Treit, Kirstine N. Bojsen-Møller, Christoffer Martinussen, Nils B. Jørgensen, Signe S. Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C. Keilhauer, Jens J. Holst, Sten Madsbad, Matthias Mann Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery published pages: 601-612.e3, ISSN: 2405-4712, DOI: 10.1016/j.cels.2018.10.012 |
Cell Systems 7/6 | 2019-04-30 |
| 2018 |
Magnus E. Jakobsson, Jędrzej M. Małecki, Levon Halabelian, Benedikt S. Nilges, Rita Pinto, Srikanth Kudithipudi, Stephanie Munk, Erna Davydova, Fawzi R. Zuhairi, Cheryl H. Arrowsmith, Albert Jeltsch, Sebastian A. Leidel, Jesper V. Olsen, Pål Ø. Falnes The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates published pages: 3411, ISSN: 2041-1723, DOI: 10.1038/s41467-018-05646-y |
Nature Communications 9/1 | 2019-04-30 |
| 2018 |
Yu-Hsien Lin, Vojtech Franc, Albert J. R. Heck Similar Albeit Not the Same: In-Depth Analysis of Proteoforms of Human Serum, Bovine Serum, and Recombinant Human Fetuin published pages: 2861-2869, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00318 |
Journal of Proteome Research 17/8 | 2019-04-30 |
| 2018 |
Ashley L. Comes, Sergi Papiol, Thorsten Mueller, Philipp E. Geyer, Matthias Mann, Thomas G. Schulze Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future published pages: 160, ISSN: 2158-3188, DOI: 10.1038/s41398-018-0219-2 |
Translational Psychiatry 8/1 | 2019-04-30 |
| 2016 |
Kyle L. Fort, Andrey Dyachenko, Clement M. Potel, Eleonora Corradini, Fabio Marino, Arjan Barendregt, Alexander A. Makarov, Richard A. Scheltema, Albert J. R. Heck Implementation of Ultraviolet Photodissociation on a Benchtop Q Exactive Mass Spectrometer and Its Application to Phosphoproteomics published pages: 2303-2310, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.5b04162 |
Analytical Chemistry 88/4 | 2019-04-30 |
| 2016 |
Philip Lössl, Andrea M. Brunner, Fan Liu, Aneika C. Leney, Masami Yamashita, Richard A. Scheltema, Albert J. R. Heck Deciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System published pages: 445-455, ISSN: 2374-7943, DOI: 10.1021/acscentsci.6b00053 |
ACS Central Science 2/7 | 2019-04-30 |
| 2016 |
Sem Tamara, Andrey Dyachenko, Kyle L. Fort, Alexander A. Makarov, Richard A. Scheltema, Albert J. R. Heck Symmetry of Charge Partitioning in Collisional and UV Photon-Induced Dissociation of Protein Assemblies published pages: 10860-10868, ISSN: 0002-7863, DOI: 10.1021/jacs.6b05147 |
Journal of the American Chemical Society 138/34 | 2019-04-30 |
| 2016 |
Philip Lössl, Michiel van de Waterbeemd, Albert JR Heck The diverse and expanding role of mass spectrometry in structural and molecular biology published pages: 2634-2657, ISSN: 0261-4189, DOI: 10.15252/embj.201694818 |
The EMBO Journal 35/24 | 2019-04-30 |
| 2016 |
Dmitry Grinfeld, Konstantin Aizikov, Arne Kreutzmann, Eugen Damoc, Alexander Makarov Phase-Constrained Spectrum Deconvolution for Fourier Transform Mass Spectrometry published pages: , ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b03636 |
Analytical Chemistry | 2019-04-30 |
| 2016 |
Chiara Francavilla, Moreno Papetti, Kristoffer T G Rigbolt, Anna-Kathrine Pedersen, Jon O Sigurdsson, Giuseppe Cazzamali, Gopal Karemore, Blagoy Blagoev, Jesper V Olsen Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking published pages: 608-618, ISSN: 1545-9993, DOI: 10.1038/nsmb.3218 |
Nature Structural & Molecular Biology 23/6 | 2019-04-30 |
| 2016 |
Anna Secher, Christian D. Kelstrup, Kilian W. Conde-Frieboes, Charles Pyke, Kirsten Raun, Birgitte S. Wulff, Jesper V. Olsen Analytic framework for peptidomics applied to large-scale neuropeptide identification published pages: 11436, ISSN: 2041-1723, DOI: 10.1038/ncomms11436 |
Nature Communications 7 | 2019-04-30 |
| 2016 |
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity published pages: 13397, ISSN: 2041-1723, DOI: 10.1038/ncomms13397 |
Nature Communications 7 | 2019-04-30 |
| 2016 |
Stefka Tyanova, Tikira Temu, Pavel Sinitcyn, Arthur Carlson, Marco Y Hein, Tamar Geiger, Matthias Mann, Jürgen Cox The Perseus computational platform for comprehensive analysis of (prote)omics data published pages: 731-740, ISSN: 1548-7091, DOI: 10.1038/nmeth.3901 |
Nature Methods 13/9 | 2019-04-30 |
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