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miRNA-DisEASY SIGNED

microRNA biomarkers in an innovative biophotonic sensor kit for high-specific diagnosis

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

miRNA-DisEASY project word cloud

Explore the words cloud of the miRNA-DisEASY project. It provides you a very rough idea of what is the project "miRNA-DisEASY" about.

medical expression illness genexplain comprehension created discovery transcriptomics context gene nucleic forces free disease huge school groups turn spain destina scientific santa sampling costly technological parties decision error pathological optical acid diagnostic respect integration brazil molecules microelectronics bioinformatic started collaborations parallel chemical skills network promise recognition germany point detection small nowadays manufacturing micrornas mirnas reliability continue rna progress expressed clinical refined outputs mirna companies joined knowhow tools catarina microelectronic cancer showing patented kit universities close experimental innovative regulation academic optoi granada humans healthcare continuing lung preparations care italy combined noncoding environment since biomarkers detector optimization hannover 2001 amplifications site trento genomics validation semiconductor ethnic

Project "miRNA-DisEASY" data sheet

The following table provides information about the project.

Coordinator	OPTOELETTRONICA ITALIA SRL Organization address address: VIA VIENNA 8 city: TRENTO postcode: 38121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.optoi.com/mirnadiseasy
Total cost	490˙500 €
EC max contribution	445˙500 € (91%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-12-01 to 2019-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OPTOELETTRONICA ITALIA SRL OPTOELETTRONICA ITALIA SRL Organization address address: VIA VIENNA 8 city: TRENTO postcode: 38121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRENTO)	coordinator	126˙000.00
2	UNIVERSITA DEGLI STUDI DI TRENTO UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRENTO)	participant	126˙000.00
3	DESTINA GENOMICA DESTINA GENOMICA Organization address address: AVENIDA DE LA INNOACI0N 1 city: GRANADA postcode: 18100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GRANADA)	participant	112˙500.00
4	MEDIZINISCHE HOCHSCHULE HANNOVER MEDIZINISCHE HOCHSCHULE HANNOVER Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 website: www.mh-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	36˙000.00
5	UNIVERSIDAD DE GRANADA UNIVERSIDAD DE GRANADA Organization address address: CUESTA DEL HOSPICIO SN city: GRANADA postcode: 18071 website: www.ugr.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GRANADA)	participant	27˙000.00
6	GENEXPLAIN GMBH GENEXPLAIN GMBH Organization address address: AM EXER 19 B city: WOLFENBUTTEL postcode: 38302 website: www.genexplain.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WOLFENBUTTEL)	participant	18˙000.00
7	UNIVERSIDADE FEDERAL DE SANTA CATARINA. UNIVERSIDADE FEDERAL DE SANTA CATARINA. Organization address address: CAMPUS UNIVERSITARIO TRINDADE city: FLORIANOPOLIS postcode: 88040-900 website: www.ufsc.br contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (FLORIANOPOLIS)	partner	0.00

Map

Project objective

Since 2001’s discovery of microRNAs (miRNAs) in humans, progress in genomics and transcriptomics has increased our comprehension of gene expression regulation. miRNAs are small, noncoding RNA molecules showing huge promise as clinical biomarkers and diagnostic tools for illness and disease, as significant changes in their expression occur in response to pathological states. However, miRNA detection is still challenging nowadays, since costly, complex sample preparations and RNA amplifications are not yet reliable enough for clinical decision making. In this context, three innovative EU companies, Optoi Microelectronics - with microelectronic knowhow and manufacturing skills - DestiNA Genomics - with ‘error free’ chemical technology for microRNAs recognition – and GeneXplain – with bioinformatic capabilities - joined forces with four key academic research groups from the Universities of Trento (Italy), Granada (Spain), Hannover Medical School (Germany) and Santa Catarina (Brazil). All the parties combined their knowledge with respect to miRNA biomarkers with a particular focus on lung cancer, to develop a novel and reliable miRNA detection system for this disease. To this end, research collaborations will address the analysis of miRNAs specifically over-expressed in lung cancer, continuing experimental work already started in the past years, but with greater integration and focus. Existing close partnerships with healthcare institutions will be strengthened, ensuring multi-site and multi-ethnic sampling. In parallel, optimization and validation of a miRNA detection kit based on Optoi semiconductor optical detector will continue. The DestiNA patented technology for specific nucleic acid recognition will be refined to reach the integration and result reliability required for use in clinical point of care testing. The strong network created between the companies and the academic institutions will thus provide a unique scientific and technological environment to turn the research outputs into an innovative product for healthcare advance and progress.

Deliverables

List of deliverables.
Report on training activities on management skills	Documents, reports	2020-01-14 15:16:51
Report on outreach and communication activities	Documents, reports	2020-01-14 15:16:33
Validation with clinical samples	Documents, reports	2020-01-14 15:15:32
Report on lectures and techical training	Documents, reports	2020-01-14 15:16:24
Organization of final conference	Other	2020-01-14 15:16:49
Report on performance of miRNA biomarker in FFPE samples, fine-needle aspirate and sputum	Documents, reports	2019-07-22 09:19:45
Report on common protocols for miRNA detection	Documents, reports	2019-07-22 09:19:45
Project website launch	Websites, patent fillings, videos etc.	2019-07-22 09:19:45

Take a look to the deliverables list in detail: detailed list of miRNA-DisEASY deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Emilio Garcia-Fernandez, M. Carmen Gonzalez-Garcia, Salvatore Pernagallo, Maria J. Ruedas-Rama, Mario A. Fara, Francisco J. LÃ³pez-Delgado, James W. Dear, Hugh Ilyine, Cristina Ress, Juan J. DÃaz-MochÃ³n, Angel Orte miR-122 direct detection in human serum by time-gated fluorescence imaging published pages: , ISSN: 1359-7345, DOI: 10.1039/c9cc08069d	Chemical Communications	2019-12-16
2017	Simone Detassis, Margherita Grasso, Valerio Del Vescovo, Michela A. Denti microRNAs Make the Call in Cancer Personalized Medicine published pages: 1-20, ISSN: 2296-634X, DOI: 10.3389/fcell.2017.00086	Frontiers in Cell and Developmental Biology 5	2019-07-22

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The information about "MIRNA-DISEASY" are provided by the European Opendata Portal: CORDIS opendata.

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