miRNA-DisEASY SIGNED
microRNA biomarkers in an innovative biophotonic sensor kit for high-specific diagnosis
Total Cost €
0EC-Contrib. €
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0miRNA-DisEASY project word cloud
Explore the words cloud of the miRNA-DisEASY project. It provides you a very rough idea of what is the project "miRNA-DisEASY" about.
Project "miRNA-DisEASY" data sheet
The following table provides information about the project.
| Coordinator |
OPTOELETTRONICA ITALIA SRL
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | http://www.optoi.com/mirnadiseasy |
| Total cost | 490˙500 € |
| EC max contribution | 445˙500 € (91%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2015 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-12-01 to 2019-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | OPTOELETTRONICA ITALIA SRL | IT (TRENTO) | coordinator | 126˙000.00 |
| 2 | UNIVERSITA DEGLI STUDI DI TRENTO | IT (TRENTO) | participant | 126˙000.00 |
| 3 | DESTINA GENOMICA | ES (GRANADA) | participant | 112˙500.00 |
| 4 | MEDIZINISCHE HOCHSCHULE HANNOVER | DE (HANNOVER) | participant | 36˙000.00 |
| 5 | UNIVERSIDAD DE GRANADA | ES (GRANADA) | participant | 27˙000.00 |
| 6 | GENEXPLAIN GMBH | DE (WOLFENBUTTEL) | participant | 18˙000.00 |
| 7 | UNIVERSIDADE FEDERAL DE SANTA CATARINA. | BR (FLORIANOPOLIS) | partner | 0.00 |
Map
Project objective
Since 2001’s discovery of microRNAs (miRNAs) in humans, progress in genomics and transcriptomics has increased our comprehension of gene expression regulation. miRNAs are small, noncoding RNA molecules showing huge promise as clinical biomarkers and diagnostic tools for illness and disease, as significant changes in their expression occur in response to pathological states. However, miRNA detection is still challenging nowadays, since costly, complex sample preparations and RNA amplifications are not yet reliable enough for clinical decision making. In this context, three innovative EU companies, Optoi Microelectronics - with microelectronic knowhow and manufacturing skills - DestiNA Genomics - with ‘error free’ chemical technology for microRNAs recognition – and GeneXplain – with bioinformatic capabilities - joined forces with four key academic research groups from the Universities of Trento (Italy), Granada (Spain), Hannover Medical School (Germany) and Santa Catarina (Brazil). All the parties combined their knowledge with respect to miRNA biomarkers with a particular focus on lung cancer, to develop a novel and reliable miRNA detection system for this disease. To this end, research collaborations will address the analysis of miRNAs specifically over-expressed in lung cancer, continuing experimental work already started in the past years, but with greater integration and focus. Existing close partnerships with healthcare institutions will be strengthened, ensuring multi-site and multi-ethnic sampling. In parallel, optimization and validation of a miRNA detection kit based on Optoi semiconductor optical detector will continue. The DestiNA patented technology for specific nucleic acid recognition will be refined to reach the integration and result reliability required for use in clinical point of care testing. The strong network created between the companies and the academic institutions will thus provide a unique scientific and technological environment to turn the research outputs into an innovative product for healthcare advance and progress.
Deliverables
| Report on training activities on management skills | Documents, reports | 2020-01-14 15:16:51 |
| Report on outreach and communication activities | Documents, reports | 2020-01-14 15:16:33 |
| Validation with clinical samples | Documents, reports | 2020-01-14 15:15:32 |
| Report on lectures and techical training | Documents, reports | 2020-01-14 15:16:24 |
| Organization of final conference | Other | 2020-01-14 15:16:49 |
| Report on performance of miRNA biomarker in FFPE samples, fine-needle aspirate and sputum | Documents, reports | 2019-07-22 09:19:45 |
| Report on common protocols for miRNA detection | Documents, reports | 2019-07-22 09:19:45 |
| Project website launch | Websites, patent fillings, videos etc. | 2019-07-22 09:19:45 |
Take a look to the deliverables list in detail: detailed list of miRNA-DisEASY deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Emilio Garcia-Fernandez, M. Carmen Gonzalez-Garcia, Salvatore Pernagallo, Maria J. Ruedas-Rama, Mario A. Fara, Francisco J. López-Delgado, James W. Dear, Hugh Ilyine, Cristina Ress, Juan J. DÃaz-Mochón, Angel Orte miR-122 direct detection in human serum by time-gated fluorescence imaging published pages: , ISSN: 1359-7345, DOI: 10.1039/c9cc08069d |
Chemical Communications | 2019-12-16 |
| 2017 |
Simone Detassis, Margherita Grasso, Valerio Del Vescovo, Michela A. Denti microRNAs Make the Call in Cancer Personalized Medicine published pages: 1-20, ISSN: 2296-634X, DOI: 10.3389/fcell.2017.00086 |
Frontiers in Cell and Developmental Biology 5 | 2019-07-22 |
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The information about "MIRNA-DISEASY" are provided by the European Opendata Portal: CORDIS opendata.