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EPIC SIGNED

Exploiting Protein Complexes that Induce Cell-death

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EPIC project word cloud

Explore the words cloud of the EPIC project. It provides you a very rough idea of what is the project "EPIC" about.

inappropriate ers award underpin hampered throughput training realise establishment apoptosome epic small effort cancer integrating pharma absence assays transfer esrs leads therapeutic national disease protein luciferase screening reagents intellectual content cells property industry inducing world decisions inward skill life inability technologies conform degenerative time demonstrable diseases utility plethora generate events stage complexes agencies resonance communal benefit academia death molecules network biotech mobility outside career skills necrosome split discovery therapeutics made form molecule fluorescence sustain expertise

Project "EPIC" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.ep-ic.eu
Total cost	607˙500 €
EC max contribution	607˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	405˙000.00
2	PROTOQSAR 2000 SL PROTOQSAR 2000 SL Organization address address: C SALVADOR FERRANDIS LUNA 45 PTA 23 city: VALENCIA postcode: 46018 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	81˙000.00
3	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	67˙500.00
4	FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE Organization address address: CALLE EDUARDO PRIMO YUFERA 3 city: VALENCIA postcode: 46012 website: http://www.cipf.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	27˙000.00
5	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	27˙000.00
6	TARBIAT MODARES UNIVERSITY (INSTRUCTOR'S TRAINING UNIVERSITY) TARBIAT MODARES UNIVERSITY (INSTRUCTOR'S TRAINING UNIVERSITY) Organization address address: INTERSECTION OF SHAHID CHAMRAN AND JALAL AL AHMAD HIGHWAY city: TEHRAN postcode: 14115 175 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IR (TEHRAN)	partner	0.00

Map

Project objective

The formation of specific protein complexes are key events in life-and-death decisions made by cells. Inappropriate decisions underpin a plethora of disease conditions from degenerative diseases to cancer while the role of the complexes in these processes make them important therapeutic targets. Our ability to develop small molecules to target death-inducing protein complexes has been hampered by an inability to measure complex formation in cells in real-time and by the absence of robust high-throughput assays for the discovery of new lead molecules that target these complexes. The proposed network (EPIC) will address both of these problems by developing new approaches to measure necrosome and apoptosome formation in real-time as well as new high-throughput and high-content screening assays using Fluorescence resonance transfer and split-luciferase technologies. EPIC will conform with the H2020 work programme by integrating research activity, novel reagents and expertise across Europe and world through the mobility, knowledge transfer and training of experienced and early stage researchers from within and without the EU. EPIC will realise the potential of researchers through the development of new skill-sets, the transfer new skills between academia and industry, and the development of career opportunities for EU ESRs and ERs. A key part of this activity is the mobility of non-EU researchers and the inward transfer of essential knowledge from outside the EU to benefit EU-based research. Establishment of EPIC through RISE will generate lead molecules with demonstrable utility and knowledge that will underpin applications to national funding agencies to sustain the communal effort beyond the life of the RISE award. It will also generate intellectual property that will enable the network to approach biotech and pharma to form academia-industry partnerships that will further develop small molecule leads as therapeutics.

Deliverables

List of deliverables.
Publications	Documents, reports	2020-02-27 15:41:36
Patents	Documents, reports	2020-02-12 17:26:02

Take a look to the deliverables list in detail: detailed list of EPIC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Amin Tashakor, Mahshid Hâ€Dehkordi, Enda O\'Connell, Sergi Gomez Ganau, Rafael Gozalbes, Leif A. Eriksson, Saman Hosseinkhani, Howard O. Fearnhead A new splitâ€luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation published pages: 1194-1203, ISSN: 2211-5463, DOI: 10.1002/2211-5463.12646	FEBS Open Bio 9/7	2019-11-18
2017	Howard O Fearnhead, Peter Vandenabeele, Tom Vanden Berghe How do we fit ferroptosis in the family of regulated cell death? published pages: 1991-1998, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.149	Cell Death and Differentiation 24/12	2019-08-06
2018	Ali Reza Noori, Elaheh Sadat Hosseini, Maryam Nikkhah, Saman Hosseinkhani Apoptosome formation upon overexpression of native and truncated Apaf-1 in cell-free and cell-based systems published pages: 46-51, ISSN: 0003-9861, DOI: 10.1016/j.abb.2018.01.017	Archives of Biochemistry and Biophysics 642	2019-08-06

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