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TROJANANOHORSE SIGNED

Hybrid immune-eluding nanocrystals as smart and active theranostic weapons against cancer

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TROJANANOHORSE project word cloud

Explore the words cloud of the TROJANANOHORSE project. It provides you a very rough idea of what is the project "TROJANANOHORSE" about.

displaying theranostics diagnostic trojananohorse efficient horizons smart mechanism generation impacting biodegrading shell multifunctional killing comprise fate organism blood scientific socio relies release chemical multidisciplinary proved malignant ultimate emission nanocrystalline hemocompatibility biological therapy cell biomimetic validated benefits toxicity core therapeutic technological intrinsic standardized drugs cells innovative immunogenic emissions biology toward tnh functions absence science materials engineering economic thrombogenicity imaging chemotherapeutic nanosized leukaemia chemistry nanomedicine overcome light protocols nanomaterial hosting cancer medicine immunogenicity opening treatment injectable expertise nanosystems itself diagnosis tools drug anti material safety

Project "TROJANANOHORSE" data sheet

The following table provides information about the project.

Coordinator	POLITECNICO DI TORINO Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 website: www.polito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.polito.it/TNHlab
Total cost	1˙489˙219 €
EC max contribution	1˙489˙219 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2021-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	POLITECNICO DI TORINO POLITECNICO DI TORINO Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 website: www.polito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	coordinator	1˙489˙219.00

Map

Project objective

Nanomedicine tools for cancer treatment comprise many nanosized systems, so far developed with smart functions such as efficient drug delivery and cell targeting abilities. However they remain still under-characterized in terms of immunogenicity, potential toxicity due to the materials itself or the unwanted release of drugs. To overcome these challenges this project aims to develop a new generation of multifunctional therapeutic and diagnostic (thus theranostics) nanosystems displaying non-immunogenicity, improved cancer treatment, cell imaging, and high safety for the hosting organism. The innovative concept behind this approach relies on a TrojaNanoHorse (TNH) system, here validated against leukaemia. The injectable TNH have a biomimetic non-immunogenic shell. Studies will show the intrinsic therapeutic activity of the nanocrystalline core for cancer killing, without the use of chemotherapeutic drugs, and its light emission. The hemocompatibility, anti-thrombogenicity, and targeting ability toward malignant blood cells will be proved during this project. The whole TNH would go beyond the state-of-the-art due to its biomimetic shell, absence of drugs, its safety and biodegrading fate, and light emissions for diagnosis. This project will also develop novel set-up for based therapy and diagnosis, impacting on future technology, new standardized protocols for nanomaterial safety assessment, and study chemical and biological mechanism of cancer cell killing. Achieving the ultimate goal of a multifunctional TNH will require multidisciplinary expertise in chemistry, material science, biology, medicine and engineering, opening new horizons as nanomedicine tools for efficient cancer therapy with strong scientific, technological and socio-economic benefits.

Publications

List of publications.
year	authors and title	journal	last update
2019	Francesca Susa, Tania Limongi, Bianca Dumontel, Veronica Vighetto, Valentina Cauda Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine published pages: 1979, ISSN: 2072-6694, DOI: 10.3390/cancers11121979	Cancers 11/12	2020-02-13
2019	Veronica Vighetto, Andrea Ancona, Luisa Racca, Tania Limongi, Adriano Troia, Giancarlo Canavese, Valentina Cauda The Synergistic Effect of Nanocrystals Combined With Ultrasound in the Generation of Reactive Oxygen Species for Biomedical Applications published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00374	Frontiers in Bioengineering and Biotechnology 7	2020-02-13
2019	Bianca Dumontel, Francesca Susa, Tania Limongi, Marta Canta, Luisa Racca, Angelica Chiodoni, Nadia Garino, Giulia Chiabotto, Maria L. Centomo, Ymera Pignochino, Valentina Cauda ZnO nanocrystals shuttled by extracellular vesicles as effective Trojan nano-horses against cancer cells published pages: 2815-2833, ISSN: 1743-5889, DOI: 10.2217/nnm-2019-0231	Nanomedicine 14/21	2020-02-13
2018	Matteo Battaglini, Christos Tapeinos, Ivana Cavaliere, Attilio Marino, Andrea Ancona, Nadia Garino, Valentina Cauda, Francisco Palazon, Doriana Debellis, Gianni Ciofani Design, Fabrication, and In Vitro Evaluation of Nanoceria-Loaded Nanostructured Lipid Carriers for the Treatment of Neurological Diseases published pages: 670-682, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.8b01033	ACS Biomaterials Science & Engineering 5/2	2020-02-13
2019	Tania Limongi, Francesca Susa, Valentina Cauda Nanoparticles for hematologic diseases detection and treatment published pages: 1-12, ISSN: 2398-8495, DOI: 10.15761/hmo.1000183	Hematology and Medical Oncology 4/2	2020-02-13
2018	Giancarlo Canavese, Andrea Ancona, Luisa Racca, Marta Canta, Bianca Dumontel, Federica Barbaresco, Tania Limongi, Valentina Cauda Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer published pages: 155-172, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.060	Chemical Engineering Journal 340	2019-07-08
2018	Luisa Racca, Marta Canta, Bianca Dumontel, Andrea Ancona, Tania Limongi, Nadia Garino, Marco Laurenti, Giancarlo Canavese, Valentina Cauda Zinc Oxide Nanostructures in Biomedicine published pages: 171-187, ISSN: , DOI: 10.1016/B978-0-12-814156-4.00012-4	Smart Nanoparticles for Biomedicine	2019-07-08
2017	B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese, V. Cauda Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer published pages: 8799-8813, ISSN: 2050-7518, DOI: 10.1039/c7tb02229h	Journal of Materials Chemistry B 5/44	2019-07-08
2018	Andrea Ancona, Bianca Dumontel, Nadia Garino, Benjamin Demarco, Dimitra Chatzitheodoridou, Walter Fazzini, Hanna Engelke, Valentina Cauda Lipid-Coated Zinc Oxide Nanoparticles as Innovative ROS-Generators for Photodynamic Therapy in Cancer Cells published pages: 143, ISSN: 2079-4991, DOI: 10.3390/nano8030143	Nanomaterials 8/3	2019-07-08
2019	Nadia Garino, Tania Limongi, Bianca Dumontel, Marta Canta, Luisa Racca, Marco Laurenti, Micaela Castellino, Alberto Casu, Andrea Falqui, Valentina Cauda A Microwave-Assisted Synthesis of Zinc Oxide Nanocrystals Finely Tuned for Biological Applications published pages: 212, ISSN: 2079-4991, DOI: 10.3390/nano9020212	Nanomaterials 9/2	2019-05-22
2019	Tania Limongi, Marta Canta, Luisa Racca, Andrea Ancona, Stefania Tritta, Veronica Vighetto, Valentina Cauda Improving dispersal of therapeutic nanoparticles in the human body published pages: 797-801, ISSN: 1743-5889, DOI: 10.2217/nnm-2019-0070	Nanomedicine 14/7	2019-05-22
2019	Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-RegÃ¬ Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent published pages: 11312-11321, ISSN: 2046-2069, DOI: 10.1039/c8ra10236h	RSC Advances 9/20	2019-05-22
2019	Carmine Lops, Andrea Ancona, Katia Di Cesare, Bianca Dumontel, Nadia Garino, Giancarlo Canavese, Simelys HÃ©rnandez, Valentina Cauda Sonophotocatalytic degradation mechanisms of Rhodamine B dye via radicals generation by micro- and nano-particles of ZnO published pages: 629-640, ISSN: 0926-3373, DOI: 10.1016/j.apcatb.2018.10.078	Applied Catalysis B: Environmental 243	2019-05-22

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