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MOMENDO SIGNED

Molecular Mechanisms of Endometriosis

Total Cost €

0

EC-Contrib. €

0

Partnership

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Outcomes and
results

MOMENDO project word cloud

Explore the words cloud of the MOMENDO project. It provides you a very rough idea of what is the project "MOMENDO" about.

productivity employing innovative rest metaplasia menopause mechanisms clinical respective subfertility diagnostics pain illness epigenetic etiology intercourse painful strengths molecular werf impacts utilizes outside endometrial socioeconomic endocrine worldwide lesions substantially limited surgeries embryonic persistent age treatment analogous coelomic sexual conceptual models incompletely microscopy animal hormonal academic uterus stem tissues considerable negatively experts translate chronic suppression world reproductive therapeutic tissue momendo menstruation underlying experimental invasive successfully options pelvic retrograde 51 interdisciplinary efficient proprietary hampering adult women theory 50 cells therapies progression endometriosis marker biomarker combining premature reported free deeper metastasis micrornas force disease lymphovascular iron periods patient atomic inflammatory repeated 10 endocost relationships

Project "MOMENDO" data sheet

The following table provides information about the project.

Coordinator	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.medizin.uni-muenster.de/momendo/the-project/
Project website	https://campus.uni-muenster.de/momendo/forschung/
Total cost	346˙500 €
EC max contribution	346˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	coordinator	63˙000.00
2	TERVISETEHNOLOOGIATE ARENDUSKESKUS AS TERVISETEHNOLOOGIATE ARENDUSKESKUS AS Organization address address: TEADUSPARGI TN 13 city: TARTU postcode: 50411 website: www.ccrmb.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	94˙500.00
3	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	81˙000.00
4	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	54˙000.00
5	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	40˙500.00
6	SEREND-IP GMBH SEREND-IP GMBH Organization address address: ROSTOCKWEG 25 city: MUENSTER postcode: 48147 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	13˙500.00
7	AQUILA BIOMEDICAL LIMITED AQUILA BIOMEDICAL LIMITED Organization address address: NINE THE BIOQUARTER city: EDINBURGH postcode: EH16 4UX website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	0.00
8	CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) Organization address address: GODOY CRUZ 2290 city: BUENOS AIRES postcode: C1425FQB website: www.conicet.gov.ar contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (BUENOS AIRES)	partner	0.00
9	UNIVERSIDAD DE CHILE UNIVERSIDAD DE CHILE Organization address address: Av. Libertador Bernardo O'Higgins 1058 city: SANTIAGO postcode: 10 website: www.uchile.cl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CL (SANTIAGO)	partner	0.00

Map

Project objective

Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches.

Deliverables

List of deliverables.
Effect and molecular mechanism of Syndecan-1 inhibition on endometriosis	Documents, reports	2020-04-06 12:09:09
Evaluation of anti-endocrine therapy in vitro and in vivo	Documents, reports	2020-04-06 12:09:09
In vivo and in vitro models of inflammation-associated pain	Documents, reports	2020-04-06 12:09:09
Molecular role and therapeutic potential of HA in endometriosis	Documents, reports	2020-04-06 12:09:09
Effect of herbal medicine on inflammation, angiogenesis and apoptotic resistance	Documents, reports	2020-04-06 12:09:09
Therapeutic effect of SARMS	Documents, reports	2020-04-06 12:09:09
CSC marker analysis and Nanostic analysis in patient tissues	Documents, reports	2020-04-06 12:09:09
Nocireceptive neuronal marker study	Documents, reports	2020-04-06 12:09:09
Impact of HA-CD44 inhibition on an endometriotic stem cell phenotype	Documents, reports	2020-04-06 12:09:09
Project meetings and workshops	Documents, reports	2020-04-06 12:09:09
Impact of miRNA expression on an invasive phenotype	Documents, reports	2020-04-06 12:09:09
Pathogenetic role of the NFkB pathway following iron overload	Documents, reports	2020-04-06 12:09:09
NFkB pathway analysis	Documents, reports	2020-04-06 12:09:09
Induced differentiation of ESCs and CSCs as a therapeutic approach	Documents, reports	2020-04-06 12:09:09
Identification and functional analysis of pain-related microRNAs	Documents, reports	2020-04-06 12:09:09
Role of NFkB-dependent microRNAs in endometriotic cell behaviour	Documents, reports	2020-04-06 12:09:09
Atomic force microscopy	Documents, reports	2020-04-06 12:09:08
Webpage and Social Media	Websites, patent fillings, videos etc.	2020-04-06 12:09:08
Therapeutic effects of DCA	Documents, reports	2020-04-06 12:09:08

Take a look to the deliverables list in detail: detailed list of MOMENDO deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga TÅ¡uiko, Sulev KÃµks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca SÃ¶derstrÃ¶m-Anttila, Anne-Maria Suikkari, Andres Salumets, Aila Tiitinen, Nina Kaminen-Ahola rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-018-0511-2	Clinical Epigenetics 10/1	2020-04-06
2018	Merli Saare, Kertu Liis Krigul, Triin Laisk-Podar, Sakthi Vignesh-Srinivasan, Nilufer Rahmioglu, Parameswaran Grace Lalit Kumar, Krina Zondervan, Andres Salumets, Maire Peters DNA methylation alterations - potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity? published pages: , ISSN: 0006-3363, DOI: 10.1093/biolre/ioy067	Biology of Reproduction	2020-04-06
2018	Kadri Rekker, TÃµnis Tasa, Merli Saare, KÃ¼lli Samuel, Ãœlle Kadastik, Helle Karro, Martin GÃ¶tte, Andres Salumets, Maire Peters Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375 published pages: 3789, ISSN: 1422-0067, DOI: 10.3390/ijms19123789	International Journal of Molecular Sciences 19/12	2020-04-06
2018	Deniss SÃµritsa, Hindrek Teder, Retlav Roosipuu, Hannes Tamm, Triin Laisk-Podar, Pille Soplepmann, Alan Altraja, Andres Salumets, Maire Peters Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene published pages: , ISSN: 1471-2350, DOI: 10.1186/s12881-018-0537-5	BMC Medical Genetics 19/1	2020-04-06
2018	Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, Signe AltmÃ¤e, Maire Peters, Reedik MÃ¤gi, Kaarel KrjutÅ¡kov, Mariann Koel, Francisco M CodoÃ±er, Juan Fco Martinez-Blanch, Felipe Vilella, Carlos SimÃ³n, Andres Salumets, Triin Laisk Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity published pages: 2074-2086, ISSN: 0268-1161, DOI: 10.1093/humrep/dey301	Human Reproduction 33/11	2020-04-06
2019	Hannu Koistinen, Mariann Koel, Maire Peters, Ago Rinken, Karolina Lundin, Timo Tuuri, Juha S. Tapanainen, Henrik Alfthan, Andres Salumets, Ulf-HÃ¥kan Stenman, Darja Lavogina Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG published pages: 103-109, ISSN: 0303-7207, DOI: 10.1016/j.mce.2018.09.006	Molecular and Cellular Endocrinology 479	2020-04-06
2018	Sakthivignesh Ponandai-Srinivasan, Karin L Andersson, Monica Nister, Merli Saare, Halima A Hassan, Suby J Varghese, Maire Peters, Andres Salumets, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis published pages: 1924-1938, ISSN: 0268-1161, DOI: 10.1093/humrep/dey241	Human Reproduction 33/10	2020-04-06
2017	Andreas N. SchÃ¼ring, Beatrice Dahlhues, Anna Korte, Ludwig Kiesel, Ulf Titze, Birthe HeitkÃ¶tter, Christian Ruckert, Martin GÃ¶tte The endometrial stem cell markers notch-1 and numb are associated with endometriosis published pages: 294-301, ISSN: 1472-6483, DOI: 10.1016/j.rbmo.2017.11.010	Reproductive BioMedicine Online 36	2020-04-06
2017	Merli Saare, Kadri Rekker, Triin Laisk-Podar, Nilufer Rahmioglu, Krina Zondervan, Andres Salumets, Martin G?tte, Maire Peters Challenges in endometriosis miRNA studies - from tissue heterogeneity to disease specific miRNAs published pages: 2282-2292, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2017.06.018	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863	2020-04-06
2019	Laura Ramirez Williams, Kathrin BrÃ¼ggemann, Marina Hubert, Nurjannah Achmad, Ludwig Kiesel, Sebastian D. SchÃ¤fer, Burkhard Greve, Martin GÃ¶tte Gammaâ€Secretase inhibition affects viability, apoptosis and the stem cell phenotype of endometriotic cells published pages: , ISSN: 0001-6349, DOI: 10.1111/aogs.13707	Acta Obstetricia et Gynecologica Scandinavica	2020-04-06

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