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NanoOxySens

Luminescent Polymer Nanoparticles with Aza-BODIPYs, Porphyrins and their Metal Complexes for FRET Mediated Ratiometric Oxygen Sensing

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 NanoOxySens project word cloud

Explore the words cloud of the NanoOxySens project. It provides you a very rough idea of what is the project "NanoOxySens" about.

biodegradable    polymer    phosphorescent    photophysics    phosphoresce    laboratory    cells    sensitive    expertise    complexes    quality    emission    training    internationally    molecular    energy    bright    chemistry    oxygen    phosphorescence    absorbing    discovered    sensitizers    nanoprobes    ing    triplet    multidisciplinary    nano    nanoparticle    encapsulating    formulation    transfer    excellent    brings    porphyrins    bearing    dual    materials    metal    3o2    sensitizer    ratiometric    infrared    excite    probes    scientist    outstanding    india    excellence    fret    highest    biophotonics    host    photophysical    bioimaging    acceptor    characterization    validated    fluorescence    innovative    enormous    fellowship    corresponding    animals    tuning    nps    solutions    provides    obtain    colour    possibilities    near    organic    red    polymeric    nanosciences    record    excited    cell    researcher    dyes    emissive    photosensitizers    france    interdisciplinary    bodipy    synthesis    conviction    ultra    mechanism    fluorescent    publication    nanoparticles    photobiology    device    aza    bodipys    living    investigation    designing   

Project "NanoOxySens" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITE DE STRASBOURG 

Organization address
address: RUE BLAISE PASCAL 4
city: STRASBOURG
postcode: 67081
website: http://www.unistra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Project website http://klymchenko-lab.u-strasbg.fr/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-15   to  2019-05-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG FR (STRASBOURG) coordinator 185˙076.00

Map

 Project objective

This proposed Fellowship brings together an Experienced Researcher from India with expertise in the synthesis of photosensitizers and their photophysical characterization, tuning the excited-state properties, investigation of their photophysics and photobiology with an internationally recognized Host Laboratory in France with expertise in designing fluorescent molecular and nanoparticle probes for bioimaging. This project will provide (i) interdisciplinary training of highest quality to become an outstanding scientist with excellent publication record; (ii) enhance European excellence in organic synthesis, nanosciences and biophotonics. The aim of the research project is to obtain ratiometric probes for molecular oxygen based on biodegradable polymeric nanoparticles (NPs) bearing far-red/near-infrared absorbing triplet sensitizers such as aza-BODIPYs, porphyrins and corresponding metal complexes. The project involves the synthesis of phosphorescent dyes (aza-BODIPY/porphyrins) and formulation of polymeric NPs encapsulating these dyes. The development of ultra-bright polymer nanoparticles, an innovative method recently discovered in the Host Laboratory, will enable the development of novel dual emissive polymeric NPs with the triplet sensitizers. In our design, fluorescent NPs excite triplet sensitizers through energy transfer (FRET), resulting in dual emission: fluorescence of NPs and phosphoresce of the sensitizer. Only phosphorescence of FRET acceptor is sensitive to molecular oxygen (3O2), which provides the mechanism of dual colour ratiometric response to oxygen. The approach will be further validated in solutions and in living cells. The obtained nanoprobes for oxygen will be applied to living cell and (in collaboration) to whole animals. It is our strong conviction that the possibilities of this multidisciplinary chemistry are enormous, and the end result will be the development of a simple nano-device for molecular oxygen build from biodegradable materials.

 Publications

year authors and title journal last update
List of publications.
2019 Andrey S Klymchenko, Nagappanpillai Adarsh
Ionic Aggregation-Induced Emission Dye with Bulky Counterions for Preparation of Bright Near-Infrared Polymeric Nanoparticles
published pages: -, ISSN: 2040-3364, DOI: 10.1039/c9nr04085d 		Nanoscale 48 2019-09-25

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