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PACEMech TERMINATED

The structure and molecular mechanism of transport proteins within the PACE family of multidrug efflux pumps

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EC-Contrib. €

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Partnership

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 Outcomes and results

 PACEMech project word cloud

Explore the words cloud of the PACEMech project. It provides you a very rough idea of what is the project "PACEMech" about.

regulation    light    efflux    15    career    experts    representative    pathogens    reveal    baumannii    describing    details    antimicrobial    class    laboratory    sixth    classically    supervisor    conferred    mechanisms    human    expertise    identification    resistance    multidrug    henderson    pace    biocides    lasting    family    protein    mechanism    membrane    antibiotics    proteins    diverse    transport    biochemical    biophysics    greatest    overcome    cell    combination    conducting    powerful    interfere    fundamental    superfamilies    mediate    recognised    broad    drug    vitro    structural    pump    colleagues    export    actively    founding    extensively    specialised    collaborative    health    draw    proteobacterial    links    receive    remarkably    establishing    prof    compound    extend    collections    hospital    expert    structure    paucity    peter    function    collective    worldwide    fellowship    vision    functional    training    bacterial    first    biophysical    play    pathogen    threats    genomics    acei    pumps    acinetobacter    families    molecular    data    strategies   

Project "PACEMech" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://www.astbury.leeds.ac.uk/people/staff/staffpage.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-09   to  2019-01-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

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 Project objective

Antimicrobial resistance is recognised as one of the greatest threats to human health worldwide. Multidrug efflux pumps play a major role in the development of drug resistance in bacterial pathogens. These pumps are able to actively export remarkably broad collections antibiotics and biocides out of the cell. Multidrug efflux pumps have classically been organised into five distinct families or superfamilies. Due to their importance, representative proteins from each of these families have been extensively studied.

Using a combination of functional genomics and biochemical methods to study antimicrobial resistance in the hospital pathogen Acinetobacter baumannii, I recently identified AceI, the founding member of a sixth family of multidrug efflux pumps called the Proteobacterial Antimicrobial Compound Efflux (PACE) family. The PACE family is the first new family of efflux pumps to be described in 15 years. In light of its recent identification, there is a paucity of fundamental data describing how PACE family pumps mediate drug efflux. This proposal will apply in vitro biochemical, biophysical and structural analyses to reveal molecular details of the structure and functional transport mechanism operating in PACE family pumps.

This proposal will draw on the diverse collective expertise of my Fellowship Supervisor Prof Peter Henderson and his expert colleagues in membrane protein structural analyses and biophysics. In conducting this research I will build lasting collaborative links with these experts that will extend beyond the duration of this fellowship. I will receive specialised training in powerful membrane protein analysis methods that are essential to my career goal of establishing a leading research laboratory examining membrane transport proteins, from regulation to molecular mechanisms. My laboratory vision is to develop novel strategies to interfere with drug efflux pump function and so overcome resistance conferred by this important class of proteins.

 Publications

year authors and title journal last update
List of publications.
2018 Karl A. Hassan, Qi Liu, Liam D.H. Elbourne, Irshad Ahmad, David Sharples, Varsha Naidu, Chak Lam Chan, Liping Li, Steven P.D. Harborne, Alaska Pokhrel, Vincent L.G. Postis, Adrian Goldman, Peter J.F. Henderson, Ian T. Paulsen
Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens
published pages: , ISSN: 0923-2508, DOI: 10.1016/j.resmic.2018.01.001 		Research in Microbiology 2019-06-13

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