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Glial Patterning SIGNED

The genetic basis for glial differentiation in the developing zebrafish retina.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Glial Patterning project word cloud

Explore the words cloud of the Glial Patterning project. It provides you a very rough idea of what is the project "Glial Patterning" about.

m defects underlie transcritpomic will function career neurons glial ultimately little networks molecular shaped population previously perform central physiological eye diseases disease basis genetic unattainable data glia differentiating informative positioned patterning critical doubt host broaden foundation functions profiling ask rerio remarkably zebrafish morphological danio researcher techniques first questions laboratory extensive ller brain neurological uuml biology specification

Project "Glial Patterning" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://markcharltonperkin.wixsite.com/mysite
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2018-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	195˙454.00

Map

Project objective

Glia far out number neurons in the brain and their defects are now known to be associated with many neurological diseases. Glial specification and physiological function are very well studied however, remarkably little is known about they way in which glia are positioned or shaped in order to perform their critical support functions. The goal of the present study is to broaden the field of glial development by using new techniques to ask previously unattainable questions. This central goal of this research project is carried out through an in-depth morphological, genetic and transcritpomic analyses of differentiating Müller Glia in the Zebrafish (Danio rerio) eye. Results from these studies will provide and the first extensive profiling of a differentiating glial population. Furthermore, the extensive data that will be generated in this proposal will provide a basis for many future studies on glial biology for both in the host laboratory and for the experienced researcher during his career development. Ultimately, these and future studies will provide a foundation for identifying the molecular networks that underlie glial patterning in the brain that will no doubt be informative in the study of glial related neurological disease.

Publications

List of publications.
year	authors and title	journal	last update
2017	Ryan B MacDonald, Mark Charlton-Perkins, William A Harris Mechanisms of MÃ¼ller glial cell morphogenesis published pages: 31-37, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.08.005	Current Opinion in Neurobiology 47	2019-06-13

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The information about "GLIAL PATTERNING" are provided by the European Opendata Portal: CORDIS opendata.