TRANSGENE SIGNED
Medical translation in the history of modern genomics
Total Cost €
0EC-Contrib. €
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Explore the words cloud of the TRANSGENE project. It provides you a very rough idea of what is the project "TRANSGENE" about.
Project "TRANSGENE" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF EDINBURGH
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://www.stis.ed.ac.uk/transgene |
| Total cost | 1˙498˙708 € |
| EC max contribution | 1˙498˙708 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF EDINBURGH | UK (EDINBURGH) | coordinator | 1˙498˙708.00 |
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Project objective
The translation of basic biomedical research into clinical practice has become a central concern for science policy. Policies to foster translation are being applied to large amounts of genomic information available in open-access databases. This information is the result of concerted initiatives that, in the early 2000s, determined the full genetic sequence that characterises humans and other organisms. However, when the initiatives started the goal of determining the full sequence and making the resulting information available was not universally supported. My project will investigate how and why this objective of completing the sequence was adopted in preference to other models that prioritised the usability of the data.
Newly available archives suggest that the yeast, human and pig genome initiatives underwent crucial changes from the mid-1980s onwards. In their early years, the priority had been rapid translation of results into the improvement of human and animal health. Consequently, sequence determination was limited to small areas of the genome for which there was an existing medical interest. However, as the initiatives progressed the systematic sequencing of the full genome prevailed over those approaches. My project will follow the development of these sidelined models that sought to use the sequences as they were produced, in order to investigate their significance for current translational research policies.
I will develop a collaborative framework in which archival research will be combined with insights from social studies of science and innovation studies. By doing this, I seek to bridge the current fragmentation between history of science and other fields of science studies focused on present-day events. In my project, biomedical translation will be approached as a historical process that unfolds over time and can be investigated with a cross-disciplinary set of tools, to be commonly applied to historical, contemporary and prospective studies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
James W. E. Lowe Stephen Hilgartner, Reordering Life: Knowledge and Control in the Genomics Revolution, Cambridge Massachusetts, The MIT Press, 2017, xiv + 343 pp., May 2017, $35.00/£27.95 published pages: , ISSN: 0391-9714, DOI: 10.1007/s40656-017-0171-0 |
History and Philosophy of the Life Sciences 40/1 | 2020-01-29 |
| 2018 |
James W.E. Lowe Sequencing through thick and thin: Historiographical and philosophical implications published pages: 10-27, ISSN: 1369-8486, DOI: 10.1016/j.shpsc.2018.10.007 |
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 72 | 2020-01-29 |
| 2019 |
Mark Wong, Rhodri Leng, Gil Viry, Rodrigo Liscovsky Barrera, Miguel Garcia-Sancho Human, yeast and pig genomics: sequence submissions and first sequence descriptions in the literature (1980-2015), 1980-2015 [dataset] published pages: , ISSN: , DOI: 10.7488/ds/2589 |
2020-01-29 | |
| 2019 |
Miguel GarcÃa-Sancho, Dmitriy Myelnikov Between mice and sheep: Biotechnology, agricultural science and animal models in late-twentieth century Edinburgh published pages: 24-33, ISSN: 1369-8486, DOI: 10.1016/j.shpsc.2019.01.002 |
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 75 | 2020-01-29 |
| 2018 |
James W.E. Lowe Sequencing through thick and thin: Historiographical and philosophical implications published pages: 10-27, ISSN: 1369-8486, DOI: 10.1016/j.shpsc.2018.10.007 |
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 72 | 2020-01-29 |
| 2019 |
Mark Wong, Rhodri Leng On the design of linked datasets mapping networks of collaboration in the genomic sequencing of Saccharomyces cerevisiae, Homo sapiens, and Sus scrofa published pages: 1200, ISSN: 2046-1402, DOI: 10.12688/f1000research.18656.1 |
F1000Research 8 | 2020-01-29 |
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