Opendata, web and dolomites

VISONby3DSTIM SIGNED

Restoration of visual perception by artificial stimulation performed by 3D EAO microscopy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 VISONby3DSTIM project word cloud

Explore the words cloud of the VISONby3DSTIM project. It provides you a very rough idea of what is the project "VISONby3DSTIM" about.

fast    resolution    spatial    of    perceptions    head    visual    photoactivate    ms    scanning    fold    form    prosthetic    photositmulation    connectivity    subcellular    recreating    orienting    subjective    deflectors    labyrinth    tools    activation    feasibility    cortex    units    mice    entire    optical    suggest    3d    proof    efficiency    caged    v1    reward    stimulus    microscope    500    neurotransmitters    somatic    sense    animals    magnitude    reactivate    combination    dendritic    stimulation    precise    ao    faster    roi    sensory    grant    simultaneously    responds    strategies    behaving    thereby    perception    khz    mapping    moving    assemblies    previously    optogenetic    restrained    neural    larger    patterns    clusters    preserving    neuronal    microscopy    cortical    throughput    manner    navigation    neurons    speed    restore    artificial    map    25    see    300    mapped    ultra    cell    acousto    axonal    animal    region    publications    question    electro    functional    investigation    microscopes    assembly    technologies    elicit    relates    virtual    understand    photon    biologically    computation   

Project "VISONby3DSTIM" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES 

Organization address
address: Szigony utca 43
city: Budapest
postcode: 1083
website: www.koki.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Project website http://erc.twophotonimaging.eu
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) coordinator 2˙000˙000.00

Map

 Project objective

The long-term aim of the investigation is to assess the feasibility of creating an “artificial sense” and, thereby, a possible sensory (visual) prosthetic. While working towards this goal, we will have to address the question of how neural assembly activity relates to subjective perceptions. Finding and understanding these functional assemblies will make it possible to reactivate them in a precise, biologically relevant manner to elicit similar cortical activation as visual stimulation. Recent publications suggest that cortical connectivity can be mapped by two-photon microscopy. Here we want, therefore, to develop a novel 3D Electro-Acousto-Optical microscope for high-throughput assembly mapping. The microscope will be capable of scanning neuronal activity with one order of magnitude higher speed (300-500 kHz/ROI) and simultaneously photoactivate neurons with three order of magnitude higher efficiency (2,500 – 25,000 neurons/ms) than existing 3D microscopes while preserving the subcellular resolution required to simultaneously measure the somatic, the dendritic and axonal computation units in the entire V1 region of the cortex. The microscope will be based on our current 3D AO technology; on novel ultra-fast scanning technologies; new, 10-fold faster AO deflectors; and novel (multi-ROI) scanning strategies. Using our microscope in combination with novel caged neurotransmitters and optogenetic tools, we want to map cell assemblies and to understand how they form larger clusters and how they are associated with visual features. Furthermore, as a proof-of-concept of this grant, we want to restore visual perception by recreating previously mapped assembly patterns with 3D artificial photositmulation in behaving mice and see if the animal responds to the artificial stimulus in the same way as to the visual stimulus. Moreover, we want to restore visual information based spatial navigation in head restrained animals orienting and moving in a virtual labyrinth for reward.

 Publications

year authors and title journal last update
List of publications.
2016 Gergely Szalay, Linda Judák, Gergely Katona, Katalin Ócsai, Gábor Juhász, Máté Veress, Zoltán Szadai, András Fehér, Tamás Tompa, Balázs Chiovini, Pál Maák, Balázs Rózsa
Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals
published pages: 723-738, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.10.002
Neuron 92/4 2019-05-27
2017 Daniel Hillier, Michele Fiscella, Antonia Drinnenberg, Stuart Trenholm, Santiago B Rompani, Zoltan Raics, Gergely Katona, Josephine Juettner, Andreas Hierlemann, Balazs Rozsa, Botond Roska
Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex
published pages: 960-968, ISSN: 1097-6256, DOI: 10.1038/nn.4566
Nature Neuroscience 20/7 2019-05-27
2018 Dénes Pálfi, Balázs Chiovini, Gergely Szalay, Attila Kaszás, Gergely F. Turi, Gergely Katona, Péter Ábrányi-Balogh, Milán Szőri, Attila Potor, Orsolya Frigyesi, Csilla Lukácsné Haveland, Zoltán Szadai, Miklós Madarász, Anikó Vasanits-Zsigrai, Ibolya Molnár-Perl, Béla Viskolcz, Imre G. Csizmadia, Zoltán Mucsi, Balázs Rózsa
High efficiency two-photon uncaging coupled by the correction of spontaneous hydrolysis
published pages: 1958-1970, ISSN: 1477-0520, DOI: 10.1039/C8OB00025E
Organic & Biomolecular Chemistry 16/11 2019-05-27
2016 Thomas Deneux, Attila Kaszas, Gergely Szalay, Gergely Katona, Tamás Lakner, Amiram Grinvald, Balázs Rózsa, Ivo Vanzetta
Accurate spike estimation from noisy calcium signals for ultrafast three-dimensional imaging of large neuronal populations in vivo
published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms12190
Nature Communications 7/1 2019-05-27

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "VISONBY3DSTIM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "VISONBY3DSTIM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

HydroLieve (2018)

A long-lasting non-migrating hydrogel for relieving chronic pain

Read More  

PonD (2019)

Particles-on-Demand for Multiscale Fluid Dynamics

Read More