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MIDOC

Multimodal Imaging of Disorders of Consciousness

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 MIDOC project word cloud

Explore the words cloud of the MIDOC project. It provides you a very rough idea of what is the project "MIDOC" about.

proper    competences    levels    anatomical    resonance    oscillations    neural    individuals    alterations    decisions    emergence    tool    spatial    parietal    career    researcher    plan    misdiagnosis    disorders    consciousness    limited    synergy    care    complexity    magnetic    diffusion    severity    description    secure    invasive    rhythms    impairment    training    fronto    cortical    transferable    percentage    tools    data    underlying    skills    electroencephalography    gt    neuroimaging    implications    prognosis    temporal    proposing    unknown    brain    techniques    establishing    mechanism    palliative    life    treatment    40    conscious    difficult    tensor    integrating    measured    diminished    correlate    descriptions    scientific    position    hypotheses    anatomy    thalamo    resolutions    manifestations    connectivity    fundamental    signatures    diagnosis    simultaneously    widen    disorder    imaging    patients    neurophysiological    occurs    relate    emerged    behavioural    independent    degree    group    frequency    breakdown    functional    single   

Project "MIDOC" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Project website https://icm-institute.org/en/team/team-bartolomeo-cohen-naccache/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

The diagnosis of individuals with disorders of consciousness has fundamental implications in terms of prognosis, treatment, palliative care and even proper end-of-life decisions. Diagnosis based on behavioural assessment is difficult and it is believed that misdiagnosis occurs in a large percentage of cases (> 40%). Non-invasive functional brain imaging has recently emerged as a promising tool for the diagnosis of individuals with disorders of consciousness; however, different imaging methods allow descriptions at limited spatial and temporal resolutions, and it is unknown how these findings relate to each other, to the underlying brain anatomy, and whether they are manifestations of a single fundamental mechanism underlying the impairment of conscious awareness.

The proposed research project aims to investigate individuals with disorders of consciousness by simultaneously applying these different neuroimaging techniques, thus integrating neurophysiological data across description levels and evaluating their synergy for the objective diagnosis and prognosis of patients. We address the hypotheses that alterations in brain rhythms (measured with electroencephalography) typical of individuals with disorders of consciousness (such as the emergence of low-complexity and low-frequency neural oscillations) are related to diminished fronto-parietal activity and a breakdown of thalamo-cortical functional and anatomical connectivity (functional magnetic resonance imaging; diffusion tensor imaging) and that these signatures of consciousness correlate with the severity of the disorder and the degree of conscious awareness of the patients.

In addition, we are proposing a career development plan for the applicant that includes training on scientific and transferable skills. This plan will both widen his scientific competences and provide him with the tools and experience necessary to secure a position as a leading independent researcher by establishing his own group.

 Publications

year authors and title journal last update
List of publications.
2018 Federico Cavanna, Martina G. Vilas, Matías Palmucci, Enzo Tagliazucchi
Dynamic functional connectivity and brain metastability during altered states of consciousness
published pages: 383-395, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.09.065 		NeuroImage 180 2020-01-29
2019 Charlotte Martial, Héléna Cassol, Vanessa Charland-Verville, Carla Pallavicini, Camila Sanz, Federico Zamberlan, Rocío Martínez Vivot, Fire Erowid, Earth Erowid, Steven Laureys, Bruce Greyson, Enzo Tagliazucchi
Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports
published pages: 52-69, ISSN: 1053-8100, DOI: 10.1016/j.concog.2019.01.011 		Consciousness and Cognition 69 2020-01-29
2018 Federico Zamberlan, Camila Sanz, Rocío Martínez Vivot, Carla Pallavicini, Fire Erowid, Earth Erowid, Enzo Tagliazucchi
The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines
published pages: , ISSN: 1662-5145, DOI: 10.3389/fnint.2018.00054 		Frontiers in Integrative Neuroscience 12 2020-01-29

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The information about "MIDOC" are provided by the European Opendata Portal: CORDIS opendata.

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