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UNICODE SIGNED

Evolution and Impact of Heterochromatin on a Young Drosophila Y chromosome

Total Cost €

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EC-Contrib. €

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Partnership

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 UNICODE project word cloud

Explore the words cloud of the UNICODE project. It provides you a very rough idea of what is the project "UNICODE" about.

initiated    species    responsible    small    miranda    pseudoobscura    demonstrated    innovation    showed    heterochromatin    crispr    structure    sites    multidisciplinary    proteins    entire    male    insertion    evolution    too    fundamental    hallmarks    1800    discovery    de    reveal    mechanisms    unclear    exaptation    avenue    sequences    model    insulator    definitive    human    relative    modification    newly    usually    repetitive    loci    manipulate    boundary    epigenomic    interaction    50    rna    cas9    transposable    sibling    transition    techniques    encoding    expressed    tes    precisely    young    previously    emerged    combining    host    binding    genomic    rnas    regulation    triggered    unveil    differentially    histone    resolve    neo    underpinning    basic    reshaped    generate    genome    bioinformatic    expression    novo    shifts    govern    toward    te    landscape    functional    requisite    powerful    lacks    harbours    drosophila    broad    chromosome    scrutinize    insertions    sequencing    genes    mobility    combined    framework    euchromatin    profiles    chromatin    function   

Project "UNICODE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://molevodevo.univie.ac.at/research/research-qi-zhou/
 Total cost 1˙971˙846 €
 EC max contribution 1˙971˙846 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙971˙846.00

Map

 Project objective

The transition from euchromatin to heterochromatin is a fundamental process that particularly reshaped the epigenomic landscape of Y chromosome. Its definitive genomic underpinning and broad functional impact are still unclear, as heterochromatin (e.g., that of human Y) is usually too repetitive to study. I have previously demonstrated that, the young Y (‘neo-Y’) chromosome of Drosophila miranda has just initiated such a transition, thus is a powerful model to unveil the evolution, regulation and functional interaction of heterochromatin. I showed that this neo-Y still harbours over 1800 genes, and only 20-50% of the sequences are transposable elements (TE). Over five years, I aim to: 1) precisely resolve the structure and insertion sites of TEs as a pre-requisite for studying heterochromatin, by combining state-of-art sequencing and bioinformatic techniques. 2) I will reveal the de novo heterochromatin formation triggered by TE insertions or the heterochromatin/euchromatin boundary shifts on the neo-Y, by comparing the binding profiles of histone modification hallmarks and insulator proteins of D. miranda to its sibling species D. pseudoobscura, which lacks the neo-Y. Such epigenomic changes have likely driven the exaptation or innovation of small RNA pathways that govern the TE mobility. 3) I will then identify the responsible small RNAs and their encoding loci, which are expected to have newly emerged or differentially expressed in D. miranda relative to D. pseudoobscura. 4) Finally, I will develop CRISPR/Cas9 in D. miranda to manipulate the expression of TEs encoding such small RNAs on the neo-Y, in order to scrutinize how TE/heterochromatin evolution on the Y would impact the chromatin landscape of the entire host genome. The combined aim of this multidisciplinary project is to generate a framework for understanding the basic mechanisms of how heterochromatin evolves; and open a new avenue toward the discovery of Y chromosome function beyond male determination.

 Publications

year authors and title journal last update
List of publications.
2019 Zhang, Jia-Yu; Zhou, Qi
On the regulatory evolution of new genes throughout their life history
published pages: , ISSN: 0737-4038, DOI: 10.1101/276667
Molecular Biology and Evolution 1 2019-10-29

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