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AEDNA SIGNED

Amorphous and Evolutionary DNA Nanotechnology

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 AEDNA project word cloud

Explore the words cloud of the AEDNA project. It provides you a very rough idea of what is the project "AEDNA" about.

differentiate    sized    interacting    functions    molecular    programming    techniques    soft    microgels    environmental    micromanipulation    cell    nanostructures    creation    amorphous    components    intelligent    ligand    identities    tissues    acid    evolution    acids    actuator    conceptual    nanoscaffolds    hybrid    directions    experiments    sensing    self    artificial    superstructure    ing    pave    communication    evolutionary    smart    multicomponent    sensitive    sensor    bioprinting    microfluidics    aedna    diverse    directed    principles    nucleic    pattern    behaviors    chemical    mixing    3d    nanotechnology    programmed    biological    explores    rna    individuals    collective    optimization    quorum    computation    circuits    screen    optimize    biocatalysis    functional    nanocomponents    compositions    scaled    robotics    arrangement    macroscopic    distributed    first    materials    cells    contain    dna    arranged    gel    utilized    intelligence    compartmentalization    active    adaptive    differentiation    populations   

Project "AEDNA" data sheet

The following table provides information about the project.

Coordinator		 TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website https://www.groups.ph.tum.de/en/e14/
 Total cost 2˙157˙697 €
 EC max contribution 2˙157˙697 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙157˙697.00

Map

 Project objective

Amorphous and evolutionary DNA nanotechnology (AEDNA) explores novel conceptual directions and applications for DNA nanotechnology, which are based on intelligent, DNA-programmed soft hybrid materials, and the utilization of evolutionary principles for the optimization of nucleic acid nanocomponents. Amorphous DNA nanotechnology first aims at the creation of cell-sized, DNA-programmed microgels – DNA cells – with sensor, computation, communication, and actuator functions. Interacting DNA cells will be arranged into chemical cell consortia and artificial tissues using microfluidics, micromanipulation and 3D bioprinting techniques. Spatially distributed chemical circuits will then be utilized to establish collective behaviors such as quorum sensing, pattern formation, and self-differentiation within these consortia and tissues. The approach will be further scaled up to produce multicomponent DNA gel compositions that become active and differentiate upon mixing. In evolutionary nanotechnology, techniques derived from directed molecular evolution experiments will be applied to optimize the arrangement of functional nucleic acids on DNA and RNA nanoscaffolds. Compartmentalization and microfluidics will be utilized to screen for nucleic acid nanostructures capable of superstructure formation, and also for the development of ligand-sensitive components for molecular programming. An evolutionary approach will then be applied to amorphous DNA cells, resulting in DNA cell populations which contain individuals with different molecular identities. The proposal will pave the way for the creation of macroscopic materials with DNA-programmed intelligence, resulting in novel applications for DNA nanotechnology and molecular programming in diverse fields such as environmental and biological sensing, biocatalysis, smart adaptive materials, and soft robotics.

 Publications

year authors and title journal last update
List of publications.
2019 Friedrich C. Simmel, Bernard Yurke, Hari R. Singh
Principles and Applications of Nucleic Acid Strand Displacement Reactions
published pages: 6326-6369, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.8b00580 		Chemical Reviews 119 2019-09-02
2019 Alessandro Cecconello, Friedrich C. Simmel
Controlling Chirality across Length Scales using DNA
published pages: 1805419, ISSN: 1613-6810, DOI: 10.1002/smll.201805419 		Small 15 2019-09-02
2019 Aradhana Chopra, Sandra Sagredo, Guido Grossi, Ebbe Andersen, Friedrich Simmel
Out-of-Plane Aptamer Functionalization of RNA Three-Helix Tiles
published pages: 507, ISSN: 2079-4991, DOI: 10.3390/nano9040507 		Nanomaterials 9/4 2019-09-04
2017 Friedrich C. Simmel, Rebecca Schulman
Self-organizing materials built with DNA
published pages: 913-919, ISSN: 0883-7694, DOI: 10.1557/mrs.2017.271 		MRS Bulletin 42/12 2019-06-13
2018 Kilian Vogele, Thomas Frank, Lukas Gasser, Marisa A. Goetzfried, Mathias W. Hackl, Stephan A. Sieber, Friedrich C. Simmel, Tobias Pirzer
Towards synthetic cells using peptide-based reaction compartments
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06379-8 		Nature Communications 9/1 2019-02-25
2018 Lukas Aufinger, Friedrich C. Simmel
Artificial Gel-Based Organelles for Spatial Organization of Cell-Free Gene Expression Reactions
published pages: 17245-17248, ISSN: 1433-7851, DOI: 10.1002/anie.201809374 		Angewandte Chemie International Edition 57/52 2019-02-25

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