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NEWRON SIGNED

New and mature neurons in adult circuits: telling memories apart

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEWRON project word cloud

Explore the words cloud of the NEWRON project. It provides you a very rough idea of what is the project "NEWRON" about.

adult    life    representations    intracellular    spiking    animal    subthreshold    optical    pattern    manipulate    purpose    convert    mouse    environment    representing    function    storage    decorrelated    involvement    optogenetic    dentate    resemble    intriguingly    born    input    patterns    encoded    imaging    overlapping    drive    experiments    tools    mechanisms    causally    completion    action    other    cell    behaviour    gyrus    neuronal    supplied    frontier    network    granule    mature    trigger    photon    tasks    behaviours    suprathreshold    neurons    termed    fundamental    memories    output    brain    memory    spike    small    types    population    cells    physiological    transform    monitor    distinguish    constantly    recordings    closely    navigation    questions    how    newborn    inputs    hippocampal    cellular    differentially    synaptic    ca2    suggested    interfere    insights    separation    combine    potentials    selectively    combines    incorporate    generating    virtual    circuit    molecular    serve   

Project "NEWRON" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://research.pasteur.fr/en/project/erc-2015-stg-newron/
 Total cost 1˙498˙955 €
 EC max contribution 1˙498˙955 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙498˙955.00

Map

 Project objective

How does the brain distinguish between memories that closely resemble each other? The hippocampal dentate gyrus has been suggested to serve this purpose by generating non-overlapping memory representations in a process termed “pattern separation”. Intriguingly, during adult life, the dentate gyrus is constantly supplied with new neurons, providing new circuit elements that can incorporate into the neuronal network. How the activity of new adult-born neurons and mature granule cells combines to drive the production and storage of distinct memories represents a new frontier in understanding brain function. However, to determine how these neurons transform similar synaptic input patterns into decorrelated spike output patterns representing distinct memories, we need to monitor and manipulate their subthreshold and suprathreshold activity during behaviour. To address these challenges, we will combine molecular, physiological and optical approaches in the mouse dentate gyrus during navigation in a virtual reality environment. We will use intracellular recordings to assess how hippocampal neurons convert synaptic inputs into spike output, 2-photon Ca2 imaging to monitor population activity in the hippocampal circuit, and optogenetic tools to causally test the involvement of specific cell types. These experiments will allow us to address the following key questions: 1. Which behaviours trigger action potentials in identified newborn and mature dentate gyrus neurons? 2. How do synaptic inputs drive spiking in newborn and mature neurons during behaviour? 3. How are small changes in an environment encoded by synaptic inputs to newborn and mature neurons? 4. Can we differentially manipulate the activity of new and mature cells to selectively interfere with animal behaviour during pattern separation and completion tasks? Understanding the role of new and mature neurons in hippocampal function will provide fundamental insights into the cellular mechanisms of memory formation.

 Publications

year authors and title journal last update
List of publications.
2019 Naila Haq, Christoph Schmidt-Hieber, Fernando J. Sialana, Lorenza Ciani, Janosch P. Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J. Rodenburg, Patrick M. Nolan, Elizabeth Forsythe, Michael C. Wu, Gert Lubec, P. Salinas, Michael Häusser, Philip L. Beales, Sofia Christou-Savina
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
published pages: e3000414, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.3000414
PLOS Biology 17/9 2019-12-16
2017 Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, Tiago Branco, Michael Häusser
Active dendritic integration as a mechanism for robust and precise grid cell firing
published pages: 1114-1121, ISSN: 1097-6256, DOI: 10.1038/nn.4582
Nature Neuroscience 20/8 2019-06-19
2018 Christoph Schmidt-Hieber
How Does a Memory Find Its Neurons?
published pages: 1800189, ISSN: 0265-9247, DOI: 10.1002/bies.201800189
BioEssays 40/11 2019-04-18

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