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transcriPTIon

Understanding transcriptional regulation in plant PAMP-triggered immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 transcriPTIon project word cloud

Explore the words cloud of the transcriPTIon project. It provides you a very rough idea of what is the project "transcriPTIon" about.

utilize    immunoprecipitation    prepared    unknown    exploration    thaliana    host    defence    generate    mode    immunity    co    culminating    lines    fragmented    crop    identity    reprogramming    heretofore    survival    mechanisms    triggered    chromatin    express    networks    regulation    signalling    agricultural    events    cohesive    arabidopsis    protection    perceived    strategies    elucidate    molecular    scientific    lack    cells    tfs    adaptive    broadly    protein    mediated    collection    initial    opportunity    vital    detection    me    effect    pti    transcription    array    seq    activate    pathogens    plant    international    membrane    genes    transcriptional    communication    prepare    immunoblotting    pattern    candidates    yields    plants    regardless    exposed    leader    techniques    mentorship    pamp    plasma    inducibly    transplanta    sequencing    massive    microbial    constantly    stress    recognition    establishing    immune    acting    independent    overexpressed    individual    select    graduate    patterns    receptors    lab    biotechnological    rna    pamps    pathogen    ideal   

Project "transcriPTIon" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.tsl.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-21   to  2018-09-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 183˙454.00

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 Project objective

Plants are constantly exposed to a range of microbial pathogens. As plants lack an adaptive immune system, recognition and signalling in the cells directly exposed to pathogens is vital for plant defence and survival, and thus agricultural yields. Initial detection of pathogens is mediated by plant recognition of pathogen-associated molecular patterns (PAMPs), perceived by pattern recognition receptors at the plasma membrane. These receptors activate an array of signalling events, culminating in a massive transcriptional reprogramming, leading to PAMP-triggered immunity (PTI). Although this transcriptional reprogramming is vital for establishing plant defence, our knowledge of the mechanisms by which it is mediated remains fragmented. Here I propose to utilize the TRANSPLANTA collection of Arabidopsis thaliana lines that inducibly express individual transcription factors (TFs) to generate a more cohesive understanding of transcription in plant defence. Specifically, I propose to (1) identify TFs that affect PTI when overexpressed, (2) select top candidates, acting broadly in PTI regardless of pathogen, (3) elucidate their mode of regulation, using immunoblotting and protein co-immunoprecipitation, and (4) identify their target genes via chromatin immunoprecipitation-sequencing, and effect on transcription via RNA-seq. Knowledge of the identity, regulation, and targets of TFs involved in establishing PTI will allow the exploration of heretofore unknown transcriptional networks in plant immunity, providing not only insight into this signalling process but also targets for biotechnological strategies for crop protection. My graduate work on regulation of early plant stress responses has prepared me for this project, while the experience and mentorship offered by the host lab and institution in new techniques, scientific communication, and international collaboration make this an ideal opportunity to prepare me for a future as an independent research leader.

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