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transcriPTIon

Understanding transcriptional regulation in plant PAMP-triggered immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 transcriPTIon project word cloud

Explore the words cloud of the transcriPTIon project. It provides you a very rough idea of what is the project "transcriPTIon" about.

utilize    culminating    ideal    rna    triggered    genes    defence    pamps    techniques    cohesive    host    exploration    transcription    reprogramming    lab    events    exposed    opportunity    plants    scientific    pti    inducibly    tfs    express    pamp    transcriptional    stress    constantly    arabidopsis    biotechnological    mentorship    immunoprecipitation    establishing    candidates    prepared    microbial    cells    survival    communication    identity    signalling    generate    lines    chromatin    collection    graduate    sequencing    independent    lack    mode    heretofore    detection    regardless    patterns    perceived    mechanisms    array    receptors    immunoblotting    immune    vital    plasma    networks    select    international    fragmented    unknown    protein    effect    mediated    acting    seq    massive    thaliana    me    molecular    elucidate    protection    pathogens    prepare    immunity    pattern    regulation    co    activate    individual    pathogen    overexpressed    broadly    crop    recognition    initial    agricultural    yields    adaptive    transplanta    plant    membrane    strategies    leader   

Project "transcriPTIon" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.tsl.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-21   to  2018-09-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 183˙454.00

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 Project objective

Plants are constantly exposed to a range of microbial pathogens. As plants lack an adaptive immune system, recognition and signalling in the cells directly exposed to pathogens is vital for plant defence and survival, and thus agricultural yields. Initial detection of pathogens is mediated by plant recognition of pathogen-associated molecular patterns (PAMPs), perceived by pattern recognition receptors at the plasma membrane. These receptors activate an array of signalling events, culminating in a massive transcriptional reprogramming, leading to PAMP-triggered immunity (PTI). Although this transcriptional reprogramming is vital for establishing plant defence, our knowledge of the mechanisms by which it is mediated remains fragmented. Here I propose to utilize the TRANSPLANTA collection of Arabidopsis thaliana lines that inducibly express individual transcription factors (TFs) to generate a more cohesive understanding of transcription in plant defence. Specifically, I propose to (1) identify TFs that affect PTI when overexpressed, (2) select top candidates, acting broadly in PTI regardless of pathogen, (3) elucidate their mode of regulation, using immunoblotting and protein co-immunoprecipitation, and (4) identify their target genes via chromatin immunoprecipitation-sequencing, and effect on transcription via RNA-seq. Knowledge of the identity, regulation, and targets of TFs involved in establishing PTI will allow the exploration of heretofore unknown transcriptional networks in plant immunity, providing not only insight into this signalling process but also targets for biotechnological strategies for crop protection. My graduate work on regulation of early plant stress responses has prepared me for this project, while the experience and mentorship offered by the host lab and institution in new techniques, scientific communication, and international collaboration make this an ideal opportunity to prepare me for a future as an independent research leader.

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