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4DHeart SIGNED

4D analysis of heart development and regeneration using advanced light microscopy

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

4DHeart project word cloud

Explore the words cloud of the 4DHeart project. It provides you a very rough idea of what is the project "4DHeart" about.

light multidisciplinary receive interface larvae adulthood frontier image stage perinatally introducing monitoring cardiovascular defects worldwide biocomputing congenital esrs packages death researcher biological cardiac modeling precision companies adapt disease science microscopy epigenetic facts heart training sheet will cv regeneration hearts skills suitable biophysical 20 tweezers environmental revolutionary softwares filling adult embryonic vivo later handling protocols dataset life toolbox ischemic smes profile morphogenesis cellular resolution complete software model altering bioimaging throughput found intersectorial organisms underscore manipulation visualizing mouse zebrafish academic physics questions deaths screenings cells gap bioengineer market leads optical imaging influence generate lsm genetic interrogate acquisition

Project "4DHeart" data sheet

The following table provides information about the project.

Coordinator	CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.4dheart.eu/
Total cost	1˙529˙110 €
EC max contribution	1˙529˙110 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-EID
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	247˙872.00
2	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	265˙226.00
3	CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Organization address address: Rue Laurent Fries 1 city: ILLKIRCH GRAFFENSTADEN postcode: 67404 website: www.igbmc.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ILLKIRCH GRAFFENSTADEN)	participant	262˙875.00
4	Leica Microsystems CMS GmbH Leica Microsystems CMS GmbH Organization address address: Ernst-Leitz-strasse 3 city: Wetzlar postcode: 35578 website: www.leica-microsystems.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Wetzlar)	participant	249˙216.00
5	PHILIPS IBERICA SA PHILIPS IBERICA SA Organization address address: CALLE MARIA DE PORTUGAL 1 city: MADRID postcode: 28050 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	247˙872.00
6	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	131˙437.00
7	DITABIS DIGITAL BIOMEDICAL IMAGING SYSTEMS AG DITABIS DIGITAL BIOMEDICAL IMAGING SYSTEMS AG Organization address address: FREIBURGERSTRASSE 3 city: PFORZHEIM postcode: 75179 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (PFORZHEIM)	participant	124˙608.00
8	ACQUIFER AG ACQUIFER AG Organization address address: FREIBURGER STRASSE 1-3 city: PFORZHEIM postcode: 75179 website: www.acquifer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (PFORZHEIM)	participant	0.00
9	ECOLE POLYTECHNIQUE ECOLE POLYTECHNIQUE Organization address address: ROUTE DE SACLAY city: PALAISEAU CEDEX postcode: 91128 website: http://www.polytechnique.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PALAISEAU CEDEX)	partner	0.00
10	FONDATION DE L'INSTITUT DE RECHERCHE IDIAP FONDATION DE L'INSTITUT DE RECHERCHE IDIAP Organization address address: RUE MARCONI 19 city: MARTIGNY postcode: 1920 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (MARTIGNY)	partner	0.00
11	INSTITUTO DE EMPRESA SL INSTITUTO DE EMPRESA SL Organization address address: CALLE MARIA DE MOLINA 13 city: MADRID postcode: 28006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	partner	0.00
12	Juan Sarasua Juan Sarasua Organization address address: n.a. city: Brussels postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Brussels)	partner	0.00
13	UNIVERSIDAD AUTONOMA DE MADRID UNIVERSIDAD AUTONOMA DE MADRID Organization address address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO city: MADRID postcode: 28049 website: http://www.uam.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	partner	0.00
14	UNIVERSIDAD CARLOS III DE MADRID UNIVERSIDAD CARLOS III DE MADRID Organization address address: CALLE MADRID 126 city: GETAFE (MADRID) postcode: 28903 website: http://www.uc3m.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GETAFE (MADRID))	partner	0.00
15	UNIVERSITE DE STRASBOURG UNIVERSITE DE STRASBOURG Organization address address: RUE BLAISE PASCAL 4 city: STRASBOURG postcode: 67081 website: http://www.unistra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (STRASBOURG)	partner	0.00

Map

Project objective

Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factors that influence CV development. An important way to increase our knowledge is by visualizing cardiac development in vivo. Recent advance in microscopy allows monitoring CV development at a cellular level in organisms such as the zebrafish model. Particularly revolutionary has been the development of light sheet microscopy (LSM). We want to further exploit LSM for in vivo manipulation of cells in the embryonic zebrafish heart and measure with high precision biophysical parameters, by introducing novel features to LSM such as optical tweezers. High throughput cardiac imaging protocols for zebrafish larvae suitable for screenings will be set up. We will develop softwares to enhance resolution of acquisition, large dataset handling and image-processing. The aim is to generate a toolbox to be implemented into existing software packages allowing a complete modeling of zebrafish cardiac morphogenesis. We will adapt LSM for adult zebrafish hearts to study cardiac regeneration and mouse heart development at cellular resolution. Each Early Stage Researchers (ESRs) will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (CV development, physics, biocomputing, bioimaging) as well as intersectorial (academic research, SMEs, large companies) training and will achieve unique skills on microscopy, in-vivo imaging and image analysis allowing them to interrogate questions on cardiac development and regeneration. Their profile will be at the interface of a bioengineer and a life science researcher filling a currently existing gap on the market.

Publications

List of publications.
year	authors and title	journal	last update
2019	Marina Peralta1,2,3,4, Katerina Jerabkova1,2,3,4, Tommaso Lucchesi5,6,7, Laia Ortiz Lopez1,2,3,4, 5 Benjamin Vitre8, Dong Han5,6, Laurent Guillemot5,6, Chaitanya Dingare9, Izabela Sumara1,2,3,4, 6 Nadia Mercader10,11, Virginie Lecaudey9, Benedicte Delaval8, SigolÃ¨ne M. Meilhac5,6 and 7 Julien Vermot1,2,3,4 Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis published pages: , ISSN: , DOI: 10.1101/777128	https://doi.org/10.1101/777128	2019-11-26
2019	Ines J. Marques, Eleonora Lupi, Nadia Mercader Model systems for regeneration: zebrafish published pages: dev167692, ISSN: 0950-1991, DOI: 10.1242/dev.167692	Development 146/18	2019-10-03

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The information about "4DHEART" are provided by the European Opendata Portal: CORDIS opendata.

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