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CResPace SIGNED

Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CResPace project word cloud

Explore the words cloud of the CResPace project. It provides you a very rough idea of what is the project "CResPace" about.

network arrhythmia functional disruptive cpgs quality multiple resolved reproduce patient models obstacle assimilate space central small sleep neural atrio invasive hypertension trialled obtain implements programming inputs biological ventricular underpinned simpler electrophysiological safer flexible pattern bundle rate constructed multichannel neurons time resynchronization block life heart lifespan compete forget respiratory tested tools animal pacemaker therapy apnoea feedback crespace building exceeding validated physiological fit beat left pioneer automatically motor cpg electronic autonomy bio chips adaptive optimization implants therapies data nonlinear neurological cardiorespiratory issue extend accurately sinus networks comorbidities branch patients generators made cardiac medicine sequences benefits arrhythmias disease

Project "CResPace" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF BATH Organization address address: CLAVERTON DOWN city: BATH postcode: BA2 7AY website: http://www.bath.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.crespace.eu
Total cost	4˙944˙347 €
EC max contribution	4˙944˙347 € (100%)
Programme	1. H2020-EU.1.2.2. (FET Proactive)
Code Call	FETPROACT-2016
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF BATH UNIVERSITY OF BATH Organization address address: CLAVERTON DOWN city: BATH postcode: BA2 7AY website: http://www.bath.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BATH)	coordinator	1˙548˙936.00
2	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	833˙367.00
3	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	584˙375.00
4	MEDTRONIC BAKKEN RESEARCH CENTER B.V. MEDTRONIC BAKKEN RESEARCH CENTER B.V. Organization address address: ENDEPOLSDOMEIN 5 city: MAASTRICHT postcode: 6229GW website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	550˙000.00
5	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	490˙625.00
6	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	participant	431˙668.00
7	MICROSEMI SEMICONDUCTOR LIMITED MICROSEMI SEMICONDUCTOR LIMITED Organization address address: PHASE 2 CASTLEGATE BUSINESS PARK city: GWENT postcode: NP26 5YW website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GWENT)	participant	403˙125.00
8	FAKULTNI NEMOCNICE U SV. ANNY V BRNE FAKULTNI NEMOCNICE U SV. ANNY V BRNE Organization address address: Pekarska 53 city: Brno postcode: 656 91 website: www.fnusa.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (Brno)	participant	102˙250.00

Map

Project objective

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.

Deliverables

List of deliverables.
Report and publications on the benefits of restoring adaptive respiratory sinus arrhythmia in rodents with induced heart failure	Documents, reports	2020-04-25 00:56:09
A database of electrophysiological recordings of respiratory neurons	Other	2020-04-08 13:50:30
Universal VLSI circuit models for gate variables and gate recovery times	Other	2020-04-08 13:50:30
A database of electrocardiograms, arterial O2, CO2, lung inflation and blood pressure time series recordings for dog and pigs in states ranging from rest to intense activity	Documents, reports	2020-04-08 13:50:30
Model of the mammalian respiratory CPG	Other	2020-04-08 13:50:30
Consortium website and logo	Documents, reports	2020-04-08 13:50:30
Data management plan	Documents, reports	2020-04-08 13:50:30

Take a look to the deliverables list in detail: detailed list of CResPace deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Andreas Spannbauer, Denise Traxler, Dominika Lukovic, Katrin Zlabinger, Johannes Winkler, Alfred Gugerell, PÃ©ter Ferdinandy, Derek J. Hausenloy, Noemi Pavo, Maximilian Y. Emmert, Simon P. Hoerstrup, Andras Jakab, Mariann GyÃ¶ngyÃ¶si, Martin Riesenhuber Effect of Ischemic Preconditioning and Postconditioning on Exosome-Rich Fraction microRNA Levels, in Relation with Electrophysiological Parameters and Ventricular Arrhythmia in Experimental Closed-Chest Reperfused Myocardial Infarction published pages: 2140, ISSN: 1422-0067, DOI: 10.3390/ijms20092140	International Journal of Molecular Sciences 20/9	2020-04-08
2019	Kamal Abu-Hassan, Joseph D. Taylor, Paul G. Morris, Elisa Donati, Zuner A. Bortolotto, Giacomo Indiveri, Julian F. R. Paton, Alain Nogaret Optimal solid state neurons published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13177-3	Nature Communications 10/1	2020-04-08
2019	Erin L. O\'Callaghan, Renata M. Lataro, Eva L. Roloff, Ashok S. Chauhan, Helio C. Salgado, Edward Duncan, Alain Nogaret, Julian F. R. Paton Enhancing respiratory sinus arrhythmia increases cardiac output in rats with left ventricular dysfunction published pages: , ISSN: 0022-3751, DOI: 10.1113/jp277293	The Journal of Physiology	2020-04-08
2018	Alain Nogaret, Alastair King Inhibition delay increases neural network capacity through Stirling transform published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.97.030301	Physical Review E 97/3	2020-04-08

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The information about "CRESPACE" are provided by the European Opendata Portal: CORDIS opendata.