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BrainBIT SIGNED

All-optical brain-to-brain behaviour and information transfer

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BrainBIT project word cloud

Explore the words cloud of the BrainBIT project. It provides you a very rough idea of what is the project "BrainBIT" about.

gaining imaging pathological boost animals interaction efficiency motor neuronal move brain healthy bodies optical believe elicited signatures spatial place volumes optostimulation direct views full deep subject templates external spatio pursue showing temporal technologies takes disentangle clinics probe mouse environment therapies invariant patterns physiological strategy usually stroke simultaneous subjects perform area paving complement mice relationship larvae oriented recording experiments mammals exchange writing communication functional injured rehabilitation insights advantageous paradigm transfer unprecedented stimulation ultimate recovery resolution model reading behavioural zebrafish brains pump

Project "BrainBIT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://bio.lens.unifi.it/research-projects/
Total cost	2˙370˙250 €
EC max contribution	2˙370˙250 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-12-01 to 2021-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI FIRENZE UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Florence)	coordinator	1˙900˙000.00
2	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	237˙250.00
3	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	233˙000.00

Map

Project objective

Exchange of information between different brains usually takes place through the interaction between bodies and the external environment. The ultimate goal of this project is to establish a novel paradigm of brain-to-brain communication based on direct full-optical recording and controlled stimulation of neuronal activity in different subjects. To pursue this challenging objective, we propose to develop optical technologies well beyond the state of the art for simultaneous neuronal “reading” and “writing” across large volumes and with high spatial and temporal resolution, targeted to the transfer of advantageous behaviour in physiological and pathological conditions. We will perform whole-brain high-resolution imaging in zebrafish larvae to disentangle the activity patterns related to different tasks. We will then use these patterns as stimulation templates in other larvae to investigate spatio-temporal subject-invariant signatures of specific behavioural states. This ‘pump and probe’ strategy will allow gaining deep insights into the complex relationship between neuronal activity and subject behaviour. To move towards clinics-oriented studies on brain stimulation therapies, we will complement whole-brain experiments in zebrafish with large area functional imaging and optostimulation in mammals. We will investigate all-optical brain-to-brain information transfer to boost an advantageous behaviour, i.e. motor recovery, in a mouse model of stroke. Mice showing more effective responses to rehabilitation will provide neuronal activity templates to be elicited in other animals, in order to increase rehabilitation efficiency. We strongly believe that the implementation of new technologies for all-optical transfer of behaviour between different subjects will offer unprecedented views of neuronal activity in healthy and injured brain, paving the way to more effective brain stimulation therapies.

Publications

List of publications.
year	authors and title	journal	last update
2019	Claudia Alia, Marco Terrigno, Irene Busti, Federico Cremisi, Matteo Caleo Pluripotent Stem Cells for Brain Repair: Protocols and Preclinical Applications in Cortical and Hippocampal Pathologies published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2019.00684	Frontiers in Neuroscience 13	2020-02-06
2018	Di Giovanna, Antonino Paolo; Tibo, Alessandro; Silvestri, Ludovico; MÃ¼llenbroich, Marie Caroline; Costantini, Irene; Allegra Mascaro, Anna Letizia; Sacconi, Leonardo; Frasconi, Paolo; Pavone, Francesco Saverio Whole-brain vasculature reconstruction at the single capillary level published pages: , ISSN: 2045-2322, DOI: 10.1101/191502	Scientific Reports 2	2019-10-03
2019	Elena Montagni, Francesco Resta, Emilia Conti, Alessandro Scaglione, Maria Pasquini, Silvestro Micera, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone Wide-field imaging of cortical neuronal activity with red-shifted functional indicators during motor task execution published pages: 74001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aaf26c	Journal of Physics D: Applied Physics 52/7	2019-07-30
2019	Marco Pisanello, Filippo Pisano, Minsuk Hyun, Emanuela Maglie, Antonio Balena, Massimo De Vittorio, Bernardo L. Sabatini, Ferruccio Pisanello The Three-Dimensional Signal Collection Field for Fiber Photometry in Brain Tissue published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2019.00082	Frontiers in Neuroscience 13	2019-07-30
2017	L. Turrini, C. Fornetto, G. Marchetto, M. C. MÃ¼llenbroich, N. Tiso, A. Vettori, F. Resta, A. Masi, G. Mannaioni, F. S. Pavone, F. Vanzi Optical mapping of neuronal activity during seizures in zebrafish published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03087-z	Scientific Reports 7/1	2019-08-30
2019	Antonino Paolo Di Giovanna, Caterina Credi, Alessandra Franceschini, Marie Caroline MÃ¼llenbroich, Ludovico Silvestri, Francesco Saverio Pavone Tailored Sample Mounting for Light-Sheet Fluorescence Microscopy of Clarified Specimens by Polydimethylsiloxane Casting published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00035	Frontiers in Neuroanatomy 13	2019-07-30
2019	Giuseppe Sancataldo, Ludovico Silvestri, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Francesco Saverio Pavone Advanced fluorescence microscopy for in vivo imaging of neuronal activity published pages: 758, ISSN: 2334-2536, DOI: 10.1364/optica.6.000758	Optica 6/6	2019-07-30
2019	Antonino Paolo Di Giovanna, Alessandro Tibo, Ludovico Silvestri, Marie Caroline MÃ¼llenbroich, Irene Costantini, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Paolo Frasconi, Francesco Saverio Pavone Publisher Correction: Whole-Brain Vasculature Reconstruction at the Single Capillary Level published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-42216-8	Scientific Reports 9/1	2019-07-30
2017	L. Turrini, C. Fornetto, G. Marchetto, M. C. MÃ¼llenbroich, N. Tiso, A. Vettori, F. Resta, A. Masi, G. Mannaioni, F. S. Pavone, F. Vanzi Optical mapping of neuronal activity during seizures in zebrafish published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03087-z	Scientific Reports 7/1	2019-07-30
2019	Giuseppe Sancataldo, Ludovico Silvestri, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Francesco Saverio Pavone Advanced fluorescence microscopy for in vivo imaging of neuronal activity published pages: 758, ISSN: 2334-2536, DOI: 10.1364/optica.6.000758	Optica 6/6	2019-08-30
2018	Leonardo Sileo, Sebastian H. Bitzenhofer, Barbara Spagnolo, Jastyn A. PÃ¶pplau, Tobias Holzhammer, Marco Pisanello, Filippo Pisano, Elisa Bellistri, Emanuela Maglie, Massimo De Vittorio, Patrick Ruther, Ileana L. Hanganu-Opatz, Ferruccio Pisanello Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00771	Frontiers in Neuroscience 12	2019-07-30
2019	Antonino Paolo Di Giovanna, Alessandro Tibo, Ludovico Silvestri, Marie Caroline MÃ¼llenbroich, Irene Costantini, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Paolo Frasconi, Francesco Saverio Pavone Publisher Correction: Whole-Brain Vasculature Reconstruction at the Single Capillary Level published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-42216-8	Scientific Reports 9/1	2019-08-30
2018	M. Pisanello, F. Pisano, M. Hyun, E. Maglie, Antonio Balena, M. De Vittorio, B. L. Sabatini, F. Pisanello Analytical and empirical measurement of fiber photometry signal volume in brain tissue published pages: , ISSN: , DOI:		2019-06-13
2017	Pavone, Francesco; Costantini, Irene; Di Giovanna, Antonino; Silvestri, Ludovico; Mascaro, Anna; Frasconi, Paolo; Sacconi, Leonardo; Tibo, Alessandro; Muellenbroich, Marie Whole-brain vasculature reconstruction at the single capillary level published pages: , ISSN: , DOI: 10.1101/191502	1	2019-06-13
2017	Cristina Spalletti, Claudia Alia, Stefano Lai, Alessandro Panarese, Sara Conti, Silvestro Micera, Matteo Caleo Combining robotic training and inactivation of the healthy hemisphere restores pre-stroke motor patterns in mice published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.28662	eLife 6	2019-06-13
2018	Pavone, Francesco; Sacconi, Leonardo; Vanzi, Francesco; Gheisari, Ali; Alterini, Tommaso; Di Giovanna, Antonino; Turrini, Lapo; Silvestri, Ludovico; MÃ¼llenbroich, Caroline; Costantini, Irene Increasing sensitivity and accuracy of brain-wide quantitative studies in light-sheet microscopy published pages: , ISSN: , DOI: 10.1101/230540	1	2019-06-13
2017	Eliana Sammali, Claudia Alia, Gloria Vegliante, Valentina Colombo, Nadia Giordano, Francesca Pischiutta, Giorgio B. Boncoraglio, Mario Barilani, Lorenza Lazzari, Matteo Caleo, Maria-Grazia De Simoni, Giuseppe Gaipa, Giuseppe Citerio, Elisa R. Zanier Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-07274-w	Scientific Reports 7/1	2019-06-13
2018	Alessandro Rizzo, Enrico Domenico Lemma, Filippo Pisano, Marco Pisanello, Leonardo Sileo, Massimo De Vittorio, Ferruccio Pisanello Laser micromachining of tapered optical fibers for spatially selective control of neural activity published pages: 88-95, ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.02.010	Microelectronic Engineering 192	2019-06-13
2018	Marco Pisanello, Filippo Pisano, Leonardo Sileo, Emanuela Maglie, Elisa Bellistri, Barbara Spagnolo, Gil Mandelbaum, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-22790-z	Scientific Reports 8/1	2019-06-13
2017	Costantini, Irene; MÃ¼llenbroich, Caroline; Di Giovanna, Antonino; Sacconi, Leonardo; Silvestri, Ludovico; Pavone, Francesco RAPID: Real-time image-based autofocus for all wide-field optical microscopy systems published pages: , ISSN: , DOI: 10.1101/170555	1	2019-06-13
2018	Filippo Pisano, Marco Pisanello, Leonardo Sileo, Antonio Qualtieri, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello Focused ion beam nanomachining of tapered optical fibers for patterned light delivery published pages: 41-49, ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.03.023	Microelectronic Engineering 195	2019-06-13
2017	Pavone, Francesco; Caleo, Matteo; Micera, Silvestro; Sacconi, Leonardo; Panarese, Alessandro; Quarta, Eros; Conti, Emilia; Mascaro, Anna; Alia, Claudia; Spalletti, Cristina; Di Giovanna, Antonino; Lai, Stefano Rehabilitation promotes the recovery of functional and structural features of healthy neuronal networks after stoke published pages: , ISSN: , DOI: 10.1101/141697	1	2019-06-13
2019	Antonino Paolo Di Giovanna, Caterina Credi, Alessandra Franceschini, Marie Caroline MÃ¼llenbroich, Ludovico Silvestri, Francesco Saverio Pavone Tailored Sample Mounting for Light-Sheet Fluorescence Microscopy of Clarified Specimens by Polydimethylsiloxane Casting published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00035	Frontiers in Neuroanatomy 13	2019-08-30
2018	M. Caroline MÃ¼llenbroich, Ludovico Silvestri, Antonino P. Di Giovanna, Giacomo Mazzamuto, Irene Costantini, Leonardo Sacconi, Francesco S. Pavone High-Fidelity Imaging in Brain-Wide Structural Studies Using Light-Sheet Microscopy published pages: ENEURO.0124-18.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0124-18.2018	eneuro 5/6	2019-08-30
2018	M. Caroline MÃ¼llenbroich, Lapo Turrini, Ludovico Silvestri, Tommaso Alterini, Ali Gheisari, Natascia Tiso, Francesco Vanzi, Leonardo Sacconi, Francesco S. Pavone Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2018.00315	Frontiers in Cellular Neuroscience 12	2019-08-30
2019	Giuseppe Sancataldo, Vladislav Gavryusev, Giuseppe de Vito, Lapo Turrini, Massimiliano Locatelli, Chiara Fornetto, Natascia Tiso, Francesco Vanzi, Ludovico Silvestri, Francesco Saverio Pavone Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00007	Frontiers in Neuroanatomy 13	2019-08-30

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