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PICARD

Disruptive GPCR Lead Discovery Platform Delivering New and Safer Therapeutics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PICARD project word cloud

Explore the words cloud of the PICARD project. It provides you a very rough idea of what is the project "PICARD" about.

paying inflates investment pharmaceutical patients clinical milestone spin gt reducing reaching payments service outsourcing nature profiles gpcrs receptors roi discovery society estimate designed time upfront fail stream combination price interax pharmacologically drugs custom lowering gpcr cover signalling swiss play novelty off compounds costly therapeutics company picard commercialization drug break safety candidates scherrer coupled variety inefficiencies biology 5000 trials market risks selective stages detection quality vital platform earlier paul implicated 80 biotech fte eth class companies biological protein mechanisms 375 uuml efficacy central disease diseases assays efficient fee identification human 2b trial screening leaving activation z 45 revenue functional fast successfully services lies

Project "PICARD" data sheet

The following table provides information about the project.

Coordinator	INTERAX BIOTECH AG Organization address address: PARK INNOVAARE city: VILLINGEN postcode: 5234 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://www.interaxbiotech.com/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2018
Duration (year-month-day)	from 2018-08-01 to 2018-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INTERAX BIOTECH AG INTERAX BIOTECH AG Organization address address: PARK INNOVAARE city: VILLINGEN postcode: 5234 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (VILLINGEN)	coordinator	50˙000.00

Map

Project objective

InterAx Biotech, a Swiss company and spin-off from the ETH Zürich and the Paul Scherrer Institute has built PICARD, a unique drug discovery platform for the identification of drug candidates with improved efficacy and reduced side effects for the largest class of human receptors: The G-Protein Coupled Receptors (GPCRs). These receptors play a central role in many vital biological processes and they are implicated in a large variety of human diseases. Due to their complex nature and mechanisms that lead to the disease state, only 60 out of 375 pharmacologically relevant GPCRs have been successfully targeted by drugs, leaving >80% GPCRs without therapeutics. Bringing a drug to the market requires an investment of up to €2.2B; out of 5000 compounds only 5 will make it to the clinical trial phase and 9 out of 10 compounds fail during costly clinical trials. This inflates the price of the drugs that reach the patients, making the society paying for inefficiencies of pharmaceutical R&D. PICARD will enable better and earlier detection of safety and efficacy profiles of GPCR-targeting drugs by increasing quality and reducing costs and time-to-market of new therapeutics. The novelty of our discovery platform lies on the combination of our screening to find novel compounds, signalling Assays that cover the most common GPCR activation aspects and our Systems Biology approach leading to highly efficient and fast delivery of functional-selective compounds. We offer custom-designed PICARD services to pharmaceutical and biotech companies that are outsourcing key stages of their drug discovery process lowering risks and greatly reducing R&D costs. The revenue stream is generated both from fee per service and from long-term drug discovery partnerships with upfront and milestone payments. We estimate reaching break-even 2 years after commercialization with 45 FTE and achieving a ROI of 4.5.

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