Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. hyheat

HyHeat

Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 HyHeat project word cloud

Explore the words cloud of the HyHeat project. It provides you a very rough idea of what is the project "HyHeat" about.

eduardo    tumoral    analyzing    icib    pioneered    position    grand    first    once    screen    independent    advantage    model    hyperthermia    supplied    molecular    efficacy    monitor    nanoparticles    tortiglione    plasmonic    whereby    experimentation    panel    laser    nps    mice    vertebrate    purposes    strategies    mechanisms    photothermal    synthesis    hyheat    engineered    functionalization    date    expertise    ablation    scientific    tissues    mediated    acute    upregulated    irradiation    instituto    di    profiled    group    therapeutic    selective    markers    final    italy    clinics    aunps    found    skills    bioactivity    treatment    national    gold    expression    line    cancer    exposed    entry    host    ht    supervisor    possibility    nanoparticle    maria    underlying    genes    cells    technique    hydra    animal    toxicity    moros    therapy    normal    council    biological    temperatures    living    surface    heat    np    stress    multidisciplinary    invasive    invertebrate    fellow    progress    career    cnr    caianiello    speed    models    soaking    heating    cibernetica    genetic    organism    dr    vivo    biology    unclear    deregulated    cellular    reduce   

Project "HyHeat" data sheet

The following table provides information about the project.

Coordinator		 CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Project website http://www.tortiglione.com/nanobiomoleculargroup/Sito/NanoBiomolecular_group.html
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 180˙277.00

Map

 Project objective

Hyperthermia (HT) is currently used as a non-invasive technique for cancer therapy, whereby biological tissues are exposed to higher than normal temperatures, for selective ablation of tumoral cells. However, the molecular mechanisms underlying the in vivo cellular responses to heat stress remain unclear to date. The overall aim of the HyHeat project is to use an invertebrate model to screen the heating capabilities of different gold nanoparticles (AuNPs) in vivo, with the grand aim of understanding the cellular responses to heat stress and therefore taking the first steps towards improving nanoparticle (NP) mediated HT efficacy for therapeutic purposes. To this end, plasmonic AuNPs with photothermal capabilities will be surface engineered and supplied to living Hydra by soaking. Upon laser irradiation of the animal, cellular and molecular expression will be profiled to monitor the overall response to NP-mediated HT. A simple invertebrate organism will be used, in line with European strategies aimed to reduce vertebrate experimentation. Once a panel of upregulated genes have been identified, the research will be conducted in mice analyzing those genes found deregulated in Hydra with the final aim to identify genetic markers of HT treatment and speed up the entry of this therapy into clinics. HyHeat is a multidisciplinary project that take advantage of the Fellow´s Dr. Maria Moros knowledge in the synthesis and functionalization of NPs, and the expertise of the host group supervisor (Dr. C. Tortiglione, Instituto di Cibernetica “Eduardo Caianiello” (ICIB), National Research Council (CNR), Italy) in molecular biology using invertebrate models. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of Hydra to test bioactivity and toxicity of NPs, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position.

 Publications

year authors and title journal last update
List of publications.
2016 Laura De Matteis, Maria Alleva, Inés Serrano-Sevilla, Sonia García-Embid, Grazyna Stepien, María Moros, Jesús de la Fuente
Controlling Properties and Cytotoxicity of Chitosan Nanocapsules by Chemical Grafting
published pages: 175, ISSN: 1660-3397, DOI: 10.3390/md14100175 		Marine Drugs 14/10 2019-07-24
2016 Gabriel Alfranca, Álvaro Artiga, Grazyna Stepien, María Moros, Scott G Mitchell, Jesús M de la Fuente
Gold nanoprism–nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation capacity
published pages: 2903-2916, ISSN: 1743-5889, DOI: 10.2217/nnm-2016-0257 		Nanomedicine 11/22 2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HYHEAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HYHEAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NSTree (2020)

Understanding substrate delivery for cell wall biosynthesis in plants

Read More  

ReproMech (2019)

The Molecular Mechanisms of Cell Fate Reprogramming in Vertebrate Eggs

Read More  

PHOTOCARBOX (2020)

Increasing the scope of CO2-utilising photoreactions: asymmetric photosynthesis of amino acids

Read More