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Lx Micelles

Coordination chemistry in doubly stabilized micelles for the tageted delivery of cytostatic drugs in cancer therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Lx Micelles project word cloud

Explore the words cloud of the Lx Micelles project. It provides you a very rough idea of what is the project "Lx Micelles" about.

polymeric    sized    prolonged    fellowship    molecule    molecules    training    release    displacement    stability    onto    micelle    permeability    sites    transnational    conjugation    broaden    therapeutic    intracellularly    biodistribution    negligible    vivo    polymer    enhanced    deposited    stabilizer    competitive    accumulate    bioresorbable    cancer    stable    transfer    treatment    amount    functions    constituting    reduce    micelles    tolerated    fast    showed    nanometer    severe    crosslinking    insufficient    limiting    intracellular    introducing    destabilized    act    excellent    drug    blood    glutathione    cytoplasm    loaded    linker    skills    pursuing    mobility    researcher    versatility    hybrid    significantly    circulation    therapy    lx    dose    retention    core    toxicity    ease    tissue    stream    powerful    tumor    drugs    scientific    transdisciplinary    safe    reversible    released    lively    coordinative    chemotherapeutic    platinum    crosslink    complementarity    advantages    effect   

Project "Lx Micelles" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

The treatment of cancer with chemotherapeutic drugs is very often associated with severe side effects limiting their tolerated dose and leading to insufficient therapeutic effects. The application of such drugs in nanometer-sized micelles may improve their biodistribution, but in vivo studies showed fast drug release in the blood stream. We aim for prolonged drug retention and intracellular release by introducing the stable, yet reversible Lx linker in the core of bioresorbable polymeric micelles. This coordinative platinum linker will have two functions: (1) it will facilitate the stable conjugation between the drug molecule and the polymer molecules constituting the micelle and (2) it will act as a stabilizer between the polymer molecules constituting the micelle. This will result in excellent stability of the drug-loaded micelles in circulation. Due to the enhanced permeability and retention effect the micelles will accumulate in tumor tissue, where they will be destabilized intracellularly and the drugs will be released from the linker in the cytoplasm after competitive glutathione displacement. The Lx linker presents various advantages over other crosslink methods, such as versatility and ease of crosslinking. No platinum-related toxicity was observed in vivo for the linker in previous research. In addition, the amount of platinum may be considered negligible since powerful drugs will be loaded onto the micelles. This approach represents a safe and unique hybrid method which has the potential to significantly increase the amount of drug deposited at the target tissue and to reduce side effects at non-target sites. By pursuing this significant step forward in cancer therapy, the fellowship will broaden the Experienced Researcher’s scientific and non-scientific skills via advanced training as well as transnational and transdisciplinary mobility. Furthermore, it will facilitate a lively transfer of knowledge between the participants due to their complementarity.

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