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DE-STRESS SIGNED

Decoding Stress Resilience

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DE-STRESS project word cloud

Explore the words cloud of the DE-STRESS project. It provides you a very rough idea of what is the project "DE-STRESS" about.

transfer susceptibility commercialising continue innovative pituitary activating mechanisms regulator differentially add gained elucidating hypothetically uses expressed lives exists mirnas regulate region industry hence he line series de functional adenylate data people society experiments maturity pacap economy expression limited collaborations peptide bnst stria stress professional career contributions date molecular structures terminalis body proteins experimental implicated regulates view forming disorders pathophysiology responsive cyclase skills decode nucleotides conduct brain additional nucleus fellowships leadership bed academia competencies resilience msca hypothesis stakeholders mediating

Project "DE-STRESS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	187˙866 €
EC max contribution	187˙866 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2018-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	coordinator	187˙866.00

Map

Project objective

Stress is a common feature of our lives yet some people respond to stress better than others, a concept known as resilience. There is a growing body of experimental data which has implicated several brain structures and molecular mechanisms. However to date there has been limited focus on the bed nucleus of the stria terminalis (BNST) and the mechanisms in this brain region which could be involved. One of several proteins expressed by the BNST, which is a key regulator of the stress response, is the pituitary adenylate cyclase-activating peptide (PACAP). But the expression of PACAP is under the control of stress-responsive nucleotides called miRNAs. Thus, there exists a complex system in the BNST which regulates the stress-response and hypothetically could be involved in mediating resilience. To test this hypothesis, the DE-STRESS project will conduct a series of experiments with the objectives of (i) determining whether PACAP expression in the BNST is different in states of resilience and susceptibility, (ii) identifying miRNAs that are differentially expressed in these states and which regulate PACAP expression and (iii) elucidating their functional effects on the stress response. Hence, the DE-STRESS project uses an innovative approach to decode the concept of stress resilience and will advance understanding of the pathophysiology of stress-induced disorders. Additional objectives of the project include dissemination and transfer of knowledge to relevant stakeholders, forming collaborations within academia and industry with a view to commercialising research findings as well as develop project management and career development skills of the applicant. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing his potential to achieve professional maturity and leadership in the field so that he may continue to make significant contributions to society and the economy.

Publications

List of publications.
year	authors and title	journal	last update
2016	Richard M. Oâ€™Connor, Anand Gururajan, Timothy G. Dinan, Paul J. Kenny, John F. Cryan All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders published pages: 1029-1044, ISSN: 0165-6147, DOI: 10.1016/j.tips.2016.10.004	Trends in Pharmacological Sciences 37/12	2019-06-13
2017	Anand Gururajan, Timothy G Dinan, John F Cryan True grit: the role of neuronal microRNAs as mediators of stress resilience published pages: 9-18, ISSN: 2352-1546, DOI: 10.1016/j.cobeha.2016.11.001	Current Opinion in Behavioral Sciences 14	2019-06-13

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