BLOODCELLSCROSSTALK SIGNED
The Crosstalk Between Red And White Blood Cells: The Case Of Fish
Total Cost €
0EC-Contrib. €
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Project "BLOODCELLSCROSSTALK" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | http://ibmc.umh.es/antiviral-immunology-en.asp |
| Total cost | 1˙823˙250 € |
| EC max contribution | 1˙823˙250 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2020-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE | ES (ELCHE) | coordinator | 1˙823˙250.00 |
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Project objective
Fish are the phylogenetically oldest vertebrate group with an immune system with clear similarities to the immune system of mammals. However, it is an actual matter of fact that the current knowledge of the fish immune system seems to lack the key piece to complete the puzzle. In 1953 Nelson described a new role of human red blood cells (RBCs) which would go beyond the simple transport of O2 to the tissues. This new role, involved in the defence against microbes, described the antibody and complement-dependent binding of microbial immune complexes to RBCs. Regardless of the importance of this finding in the field of microbial infection, this phenomenon has been poorly evaluated. Just recently, a set of biological processes relevant to immunity have been described in the RBCs of a diverse group of organisms, which include: pathogen recognition, pathogen binding and clearance and cytokines production. Furthermore, it has been demonstrated that nucleated erythrocytes from fish and avian species develop specific responses to different pathogen associated molecular patterns and produce soluble factors that modulate leukocyte activity. In the light of these pieces of evidences, and in an attempt to improve the knowledge of the immune mechanism(s) responsible for fish protection against viral infections, we raised the question: could nucleated fish erythrocytes be the key mediators of the antiviral responses? To answer this question we decided to focus our project on the evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. For that a working model composed of the rainbow trout and the viral haemorrhagic septicaemia virus (VHSV) was chosen, being the objectives of the project to evaluate: i) the implication trout RBCs (tRBCs) in the clearance of VHSV, and ii) the involvement of tRBCs in the blood transportation of the glycoprotein G of VHSV (GVHSV), the antigen encoded by the DNA vaccine.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
I. Nombela, M. Lopez-Lorigados, S. Puente-Marin, V. Chico, S. Ciordia, M.C. Mena, J. Coll, L. Mercado, L. Perez, M. Ortega-Villaizan Transcriptome and proteome analyses of red blood cells from rainbow trout challenged with viral haemorrhagic septicaemia virus published pages: 440, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.206 |
Fish & Shellfish Immunology 91 | 2020-01-20 |
| 2019 |
B. Morales-Lange, F. Guzmán, L. Lagos, M. Øverland, I. Nombela, M. Ortega-Villaizán, M. Imarai, K. Maisey, V. Wong, L. Mercado Cell surface markers for the identification of subpopulations of splenocytes from salmonids published pages: 395, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.086 |
Fish & Shellfish Immunology 91 | 2020-01-20 |
| 2019 |
V. Chico, M. Salvador-Mira, I. Nombela, S. Puente-Marin, S. Ciordi, M.C. Mena, L. Perez, J. Coll, F. Guzman, J. Encinar, L. Mercado, M. Ortega-Villaizan IFIT5 participates in the antiviral mechanisms of rainbow trout red blood cells published pages: 469, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.284 |
Fish & Shellfish Immunology 91 | 2020-01-20 |
| 2019 |
V. Chico, S. Puente-Marin, I. Nombela, S. Ciordia, M.C. Mena, B. Carracedo, A. Villena, L. Mercado, J. Coll, M. Ortega-Villaizan Rainbow trout shape-shifted red blood cells published pages: 408, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.122 |
Fish & Shellfish Immunology 91 | 2020-01-20 |
| 2019 |
Nombela, Lopez-Lorigados, Salvador-Mira, Puente-Marin, Chico, Ciordia, Mena, Mercado, Coll, Perez, Ortega-Villaizan Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets published pages: 63, ISSN: 2076-393X, DOI: 10.3390/vaccines7030063 |
Vaccines 7/3 | 2020-01-20 |
| 2019 |
S. Puente-Marin, I. Nombela, V. Chico, S. Ciordia, M.C. Mena, J. Coll, L. Mercado, M. Ortega-Villaizán Potential role of rainbow trout red blood cells as mediators in the immune response induced by DNA vaccines published pages: 425, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.164 |
Fish & Shellfish Immunology 91 | 2020-01-20 |
| 2019 |
M. Salvador-Mira, V. Chico, I. Nombela, S. Puente-Marin, S. Ciordia, M.C. Mena, L. Mercado, M. Ortega-Villaizan NKEF, an antiviral protein involved in the immune response of rainbow trout red blood cells published pages: 409, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.123 |
Fish & Shellfish Immunology 91 | 2020-01-20 |
| 2019 |
Sara Puente-Marin, Rosemary Thwaite, Luis Mercado, Julio Coll, Nerea Roher, Maria Del Mar Ortega-Villaizan Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFα and a G-VHSV Fragment published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01055 |
Frontiers in Immunology 10 | 2020-01-20 |
| 2018 |
Sara Puente-Marin, Iván Nombela, Sergio Ciordia, MarÃa Mena, Verónica Chico, Julio Coll, MarÃa Ortega-Villaizan In Silico Functional Networks Identified in Fish Nucleated Red Blood Cells by Means of Transcriptomic and Proteomic Profiling published pages: 202, ISSN: 2073-4425, DOI: 10.3390/genes9040202 |
Genes 9/4 | 2020-01-20 |
| 2017 |
Ivan Nombela, Aurora Carrion, Sara Puente-Marin, Verónica Chico, Luis Mercado, Luis Perez, Julio Coll, Maria del Mar Ortega-Villaizan Infectious pancreatic necrosis virus triggers antiviral immune response in rainbow trout red blood cells, despite not being infective published pages: 1968, ISSN: 2046-1402, DOI: 10.12688/f1000research.12994.2 |
F1000Research 6 | 2020-01-20 |
| 2018 |
Ivan Nombela, Maria del Mar Ortega-Villaizan Nucleated red blood cells: Immune cell mediators of the antiviral response published pages: e1006910, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006910 |
PLOS Pathogens 14/4 | 2020-01-20 |
| 2017 |
Ivan Nombela, Sara Puente-Marin, Veronica Chico, Luis Mercado, Luis Perez, Julio M. Coll, Amparo Estepa, Maria del Mar Ortega-Villaizan Fish red blood cells halted VHSV and IPNV infections together with mounting antiviral immune responses published pages: , ISSN: , DOI: |
10TH INTERNATIONAL SYMPOSIUM ON VIRUSES OF LOWER VERTEBRATES (ISVLV), Budapest, Hungary | 2020-01-20 |
| 2017 |
Sara Puente, Ivan Nombela, Veronica Chico, Julio Coll, Luis Mercado, Maria del Mar Ortega-Villaizán RNA-SEQ OF RAINBOW TROUT RBCs TRANSFECTED WITH A DNA VACCINE IN VITRO SHOWS A POTENTIAL ROLE OF TROUT RBCs AS MEDIATORS IN THE IMMUNE RESPONSE INDUCED BY DNA VACCINES IN FISH. published pages: , ISSN: , DOI: |
2017 International Society of Vaccines. Annual Congress 5thâ€7th October 2017, Institut Pasteur, Paris, France | 2020-01-20 |
| 2017 |
Ivan Nombela, Sara Puente-Marin, Veronica Chico, Alberto J. Villena, Begoña Carracedo, Sergio Ciordia, Maria Carmen Mena, Luis Mercado, Luis Perez, Julio Coll, Amparo Estepa, Maria del Mar Ortega-Villaizan Identification of diverse defense mechanisms in rainbow trout red blood cells in response to halted replication of VHS virus published pages: 1958, ISSN: 2046-1402, DOI: 10.12688/f1000research.12985.2 |
F1000Research 6 | 2020-01-20 |
| 2017 |
Verónica Chico,Ivan Nombela, Sara Puente-MarÃn, Sergio Ciordia, Maria Carmen Mena, Julio Coll, Maria del Mar Ortega-Villaizan Proteomic study of VHSV infected trout RBCs published pages: , ISSN: , DOI: |
10TH INTERNATIONAL SYMPOSIUM ON VIRUSES OF LOWER VERTEBRATES (ISVLV), Budapest, Hungary | 2020-01-20 |
| 2018 |
Verónica Chico, Sara Puente-Marin, Iván Nombela, Sergio Ciordia, MarÃa Mena, Begoña Carracedo, Alberto Villena, Luis Mercado, Julio Coll, MarÃa Ortega-Villaizan Shape-Shifted Red Blood Cells: A Novel Red Blood Cell Stage? published pages: 31, ISSN: 2073-4409, DOI: 10.3390/cells7040031 |
Cells 7/4 | 2020-01-20 |
| 2018 |
Sara Puente-Marin, Ivan Nombela, Veronica Chico, Sergio Ciordia, Maria Carmen Mena, Julio Coll, Luis Mercado, Maria Del Mar Ortega-Villaizan Rainbow Trout Erythrocytes ex vivo Transfection With a DNA Vaccine Encoding VHSV Glycoprotein G Induces an Antiviral Immune Response published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02477 |
Frontiers in Immunology 9 | 2020-01-20 |
| 2019 |
Ivan Nombela, Ricardo Requena-Platek, Byron Morales-Lange, Veronica Chico, Sara Puente-Marin, Sergio Ciordia, Maria Carmen Mena, Julio Coll, Luis Perez, Luis Mercado, Maria del Mar Ortega-Villaizan Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers published pages: 386, ISSN: 2073-4409, DOI: 10.3390/cells8050386 |
Cells 8/5 | 2020-01-20 |
| 2019 |
Veronica Chico, Maria Elizabhet Salvador-Mira, Ivan Nombela, Sara Puente-Marin, Sergio Ciordia, MarÃa Carmen Mena, Luis Perez, Julio Coll, Fanny Guzman, Jose Antonio Encinar, Luis Mercado, Maria del Mar Ortega-Villaizan IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00613 |
Frontiers in Immunology 10 | 2020-01-20 |
| 2019 |
Myung-Hwa Jung, Verónica Chico, Sergio Ciordia, Maria Carmen Mena, Sung-Ju Jung, Maria Del Mar Ortega-Villaizan The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00160 |
Frontiers in Immunology 10 | 2020-01-20 |
| 2019 |
Puente-Marin, Nombela, Chico, Ciordia, Mena, Perez, Coll, Ortega-Villaizan Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish published pages: 60, ISSN: 2076-393X, DOI: 10.3390/vaccines7030060 |
Vaccines 7/3 | 2020-01-20 |
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