Opendata, web and dolomites
IMPARTS
Integral Membrane Proteins – an Approach to Rank Target Stability
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0IMPARTS project word cloud
Explore the words cloud of the IMPARTS project. It provides you a very rough idea of what is the project "IMPARTS" about.
micelles
folded
unfolding
release
displacing
detergents
detergent
stems
experiments
impress
family
distinguishing
gas
ligands
unfolded
confer
discovered
realised
count
either
mass
trajectories
quantify
proof
molecule
small
actively
grant
rationalise
bound
basic
designed
assemblies
affinity
monitoring
proteins
membrane
idea
erc
structure
spectrometer
rank
lipids
drug
formulate
carry
protein
retain
binding
competitive
molecules
drugs
stability
Project "IMPARTS" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 145˙501 € |
| EC max contribution | 145˙501 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-03-01 to 2016-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 145˙501.00 |
Map
Project objective
This Proof of Concept proposal is designed to develop and test a novel way of monitoring the effects of drug binding to membrane protein targets. The idea stems from the basic research proposed in my ERC grant IMPRESS to study and rationalise the release of membrane proteins from detergent micelles in the gas phase of the mass spectrometer. During this research we discovered a new family of detergents, which we could formulate, to retain folded protein structure in the gas phase. Having achieved this goal, we then actively unfolded these assemblies in the mass spectrometer and by monitoring their unfolding trajectories we realised that we could quantify the effects of small molecule binding on protein stability. Not only can we now rank ligands according to their ability to confer stability but we can also count the number of molecules bound to a particular membrane protein target. By distinguishing bound molecules, either lipids or drugs, we can then carry out competitive binding experiments by displacing small molecules with higher affinity ligands.
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The information about "IMPARTS" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-16 10:26:28) correctly updated