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RESCUE THE HEART SIGNED

Understanding nervous mechanisms of cardioprotection to save the ischaemic and failing hearts

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RESCUE THE HEART project word cloud

Explore the words cloud of the RESCUE THE HEART project. It provides you a very rough idea of what is the project "RESCUE THE HEART" about.

neural optogenetics conditioning intense powerful technologies transgenic suffering played heart undertaken recruit parasympathetic specificity nervous autonomic cardiovascular base viral expertise training cardioprotective injury designed progression researcher neuroscience rescue pharmaco efferent ischaemia transfer phenomena limit models mechanisms ultimately mice molecular underlying genetic resolution chronic reperfusion outflows life disease selective sympathetic cardioprotection individuals instant involvement manipulation spans fundamental pathology experiments biology unprecedented modulation latest newly strategies therapeutic gene innate translational myocardial quality philosophy

Project "RESCUE THE HEART" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.researchgate.net/project/Neural-mechanisms-of-cardioprotection
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-04-01 to 2018-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

This project is designed to use the latest advances in molecular biology and neuroscience to determine the role played by the nervous mechanisms in the development of cardiovascular pathology. The project spans across distinct research fields of myocardial ischaemia/reperfusion injury, innate cardioprotective mechanisms and fundamental neuroscience and includes newly developed transgenic mice models and latest advances in viral gene transfer technology, pharmaco- and optogenetics for selective manipulation of parasympathetic or sympathetic efferent outflows to the heart. These novel genetic models offer unprecedented resolution and specificity and will be used to determine the role played by the autonomic nervous system in modulation of the myocardial ischaemia/reperfusion injury and progression of chronic heart failure. Another important part of this study will determine the involvement of neural pathways in powerful innate mechanisms of cardioprotection underlying the (pre)conditioning phenomena. The results of the proposed experiments are expected to have an instant translational potential and may lead to the development of novel therapeutic strategies which recruit innate neural mechanisms of cardioprotection to limit myocardial injury and improve quality of life of individuals suffering from heart disease. RESCUE THE HEART project includes an intense program of research and training to be undertaken by the experienced researcher and will ultimately promote effective transfer of research expertise, new technologies and research philosophy across wider European research base.

Publications

List of publications.
year	authors and title	journal	last update
2017	Fergus M O\'Farrell, Svetlana Mastitskaya, Matthew Hammond-Haley, Felipe Freitas, Wen Rui Wah, David Attwell Capillary pericytes mediate coronary no-reflow after myocardial ischaemia published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.29280	eLife 6	2019-06-13
2016	Svetlana Mastitskaya, Marina Basalay, Patrick S. Hosford, Andrew G. Ramage, Andrey Gourine, Alexander V. Gourine Identifying the Source of a Humoral Factor of Remote (Pre)Conditioning Cardioprotection published pages: e0150108, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0150108	PLOS ONE 11/2	2019-06-13
2016	Marina V. Basalay, Svetlana Mastitskaya, Aleksander Mrochek, Gareth L. Ackland, Ana Gutierrez del Arroyo, Jenifer Sanchez, Per-Ove Sjoquist, John Pernow, Alexander V. Gourine, Andrey Gourine Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning published pages: 669-676, ISSN: 0008-6363, DOI: 10.1093/cvr/cvw216	Cardiovascular Research 112/3	2019-06-13
2017	Marina Basalay, Svetlana Mastitskaya, Aleksander Mrochek, Gareth L. Ackland, Ana Gutierrez del Arroyo, Jenifer Sanchez, Per-Ove Sjoquist, John Pernow, Alexander V. Gourine, Andrey Gourine Reply: Glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning published pages: 13.2-14, ISSN: 0008-6363, DOI: 10.1093/cvr/cvw238	Cardiovascular Research 113/1	2019-06-13

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The information about "RESCUE THE HEART" are provided by the European Opendata Portal: CORDIS opendata.