FluoroCAT
Catalytic C–F Bond Functionalisation with Transition Metal Catalysis
Total Cost €
0EC-Contrib. €
0Partnership
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0FluoroCAT project word cloud
Explore the words cloud of the FluoroCAT project. It provides you a very rough idea of what is the project "FluoroCAT" about.
Project "FluoroCAT" data sheet
The following table provides information about the project.
| Coordinator |
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://crimmingroup.org/publications/publications.html |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-03-15 to 2017-03-14 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE | UK (LONDON) | coordinator | 183˙454.00 |
Map
Project objective
Fluorinated organic molecules play a pivotal role in chemical manufacture. For example, it has been estimated that approximately 20-40% of pharmaceuticals and agrochemicals contain at least one fluorine atom. Despite the fact that perfluoroarenes - aromatic hydrocarbons in which every hydrogen atom is replaced with a fluorine atom - are an inexpensive abundant chemical feedstock they are rarely used in chemical manufacture. The strong carbon–fluorine bond provides an impasse to further chemical reactions. Here we propose to develop a new catalytic method to transform inert carbon–fluorine bonds in perfluoroarenes to reactive carbon–aluminium bonds. We will transform the aluminium-containing reactive intermediates into useful products through carbon–carbon and carbon–heteroatom bond forming reactions. The overall process represents an original underpinning technology to transform inert and chemically persistent fluorinated molecules into building blocks that can be used in chemical manufacture. The ultimate goal of this work is to create a fresh paradigm for using perfluoroarenes in pharmaceutical and agrochemical programmes. The proposed programme will provide world-class training in the areas of organometallic chemistry, homogeneous catalysis and mechanistic analysis. The long-term benefits will be felt in the areas of health and food sustainability.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Olga Ekkert, Andrew J. P. White and Dr. Mark R. Crimmin Trajectory of Approach of a Zinc–Hydrogen Bond to Transition Metals published pages: 16031–16034, ISSN: 1521-3773, DOI: 10.1002/anie.201608599 |
Angew. Chem., Int. Ed. 55 | 2019-07-23 |
| 2017 |
Olga Ekkert, Andrew J. P. White, Mark R. Crimmin Stereoisomerism of bis(σ-Zincane) Complexes: Evidence for an Intramolecular Pathway published pages: 5682-5686, ISSN: 0947-6539, DOI: 10.1002/chem.201701207 |
Chemistry - A European Journal 23/24 | 2019-07-23 |
| 2015 |
Olga Ekkert, Andrew J. P. White, Harold Tomsb and Mark R. Crimmin Addition of aluminium, zinc and magnesium hydrides to rhodium(III) published pages: 5617-5622, ISSN: 2041-6520, DOI: 10.1039/C5SC01309G |
Chemical Science 6 | 2019-07-23 |
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