MEDICIS-PROMED: list of downloadable deliverables.
| title and desprition
| type |
last update |
Radiometal and 11C –based bioligands synthesis for target receptors of ovarian cancer
Lead beneficiary: EPFL (CH)
Bifunctional fluorescent and PET/treatment bioligand for ovarian cancer
Objective: Develop and validate new bifunctional fluorescent and radioactive bioligand for ovarian cancer
Expected Results: These reagents will consist of three major parts – 1) a bioligand for targeting of ovarian cancer; 2) a fluorophore for optical readout; 3) and a chelator for radiolanthanide such as Terbium (Tb). The first application of these probes would be to study their specific binding to ovarian cancer cells first in cell culture followed by biodistribution studies in animal models of ovarian cancer. The initial studies will be focused on folate receptor-alpha targeting moiety because several studies revealed that it is increased in 90–95% of patients with epithelial ovarian cancer. Moreover, the absence of folate receptor-alpha on healthy cells provides high tumor-to-normal ratios making this targeting moiety a good target for both imaging and therapeutic. Indocyanine green (ICG) will be a first choice of fluorescent reagent because of its extensive use in clinic. Terbium is known to possess excellent chelation properties to diethylene triamine pentaacetic acid (DTPA) and therefore this compound will be used in the construction of the final conjugates. In some biodistribution studies the chelate will be replaced with 11C isotope.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Collection of mass separated 11CO/CO2/CH4 at high efficiency
Mass separated beams of CO+, CO2+ and CH4+ with high efficiency
Objective: develop compact and turn-key mass separator systems for medical radioisotope production
Expected Results: The program aims to liaise the development on innovative medical RIB ongoing in Belgium (e.g. the ISOL@MYRRHA project and the University Hospital research groups on medical RIB) with CERN-MEDICIS. Different mass separators are currently operational or under the development at KUL. A new off-line mass separator to study resonance laser ionization of gas-jet based radioactive isotopes and a new laser laboratory are under construction, part of the HELIOS project.
The outcome of the program will be 1) an operational MEDICIS mass separator (based on the LISOL system), 2) ion simulation packages to optimize the beam transport with respect to efficiency and mass resolution in order to limit isotope contamination, 3) trained scientists to operate and optimize the RIB production of certain interesting isotopes and 4) active participation in the long-term development of compact and turnkey mass separator systems.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Preclinical Imaging and Animal Models – Clinical Translation on ovarian cancer
Technical leader: partner organization CHUV (CH)
Preclinical Imaging and Animal Models – Clinical Translation on ovarian cancer
Objective: Develop translational imaging and therapy with monoclonal antibodies for ovarian cancer
Expected Results: The ESR will be in charge of performing the translation from a successful preclinical model for diagnosis to a first study in humans, firstly from a diagnostic point of view, and secondarily, as a preclinical therapeutic radioimmunotherapy and then, if feasible into a therapy in humans; His supervisor, Dr. Melita Irving, (Ludwig Center for Cancer Research, University of Lausanne, Biopôle III ) will train him performing molecular biology and preclinical antibody research on ovarian cancer in mice. At CHUV, preclinical imaging will be done in nuclear medicine with μPET/SPECT/CT, and for clinical trials, PET/CT and SPECT/CT clinical scanners and radiation shielded beds for clinical therapy.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
99Mo/Tc production with metal uranium/graphene targets at CERN-MEDICIS
Metallic foil targets with protective graphene layers to produce innovative isotopes
Objective: To study the possibility and mechanisms of graphene growth on uranium, thorium and other metals to form a protective layer. To characterised the grown graphene layer and its ageing in difficult environments
Expected Results: It has been demonstrated recently, that graphene can serve as a completely impermeable membrane on a surface of a metal. Furthermore, as graphene can be grown conformal on a piece of metal of any shape, it can be used as a corrosion protection. We would like to use graphene as a corrosion protection on uranium, thorium and other metals.
Different metals allow for different mechanisms of graphene growth. We will investigate a possibility of graphene growth on uranium, thorium and other metals, the mechanisms of such growth and will optimise the process. Growth on Tantalum will first be investigated. The student will get familiar with the basic methods of graphene characterisation (AFM, SEM, Raman, etc). and develop new methods to characterise graphene on uranium.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Summary of charge breeding investigations for a future 11C treatment facility
CO molecule fast gas injection and C-->C6+ and C-->C1+ -->Cn+ charge breeding investigations
Objective: For different types of treatment ions explore the possibilities and limitations of the charge breeding stage linking the radioactive beam production and post-accelerator
Expected Results: A. Ion throughput capability of the charge breeding system as is for different type of treatment ions and the means of increasing it., by e.g. implementing alternative cooling methods in the Penning trap or using continuous mode injection into the Electron-Beam Ion-Source (EBIS). B. In collaboration with ESR1 address the beam purity by 11C16O breakup efficiency inside the Penning trap and EBIS, and stable beam contamination. C. Establish the operational conditions such as injection repetition rate, extracted pulse length and mass-to-charge ratio.. D. Literature study on Electron Cyclotron Resonance Ion Source (ECRIS) alternative charge breeding in collaboration with MEDAUSTRON.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Open training event (summer school)
Open training events (summer schools) in months 25 & 37 with the possibility of additional schools if deemed necessary.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Other |
2019-07-23 |
Cell-nucleus targeting with bioligands for Auger-thera
Design, synthesis and pre-clinical evaluation of multifunctional 161Tb complexes for cell specific targeting of DNA
Objective: 161Terbium Auger-emitting radiopharmaceuticals for the eradication of large tumor masses or small metastases for ovarian cancers
Expected Results: A Synthesis and characterization of macrocyclic bifunctional chelators (e.g. 1,4,7,10-tetraazacyclododecane DOTA) bearing a tumor-specific MAb fragment targeting moiety and a DNA-binding moiety). B Synthesis of cold Tb complexes and characterization by spectroscopic techniques. C biological evaluation of Tb-161 complexes (Damage in plasmid DNA, Cell uptake using human tumor cell lines, Radiotoxicity and mechanisms of cell death, Biodistribution and SPECT imaging in tumor-bearing mice)
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Production of theranostics 149/152Tb at CERN-MEDICIS and shipping
Production of 149/152Terbium theranostics isotopes at CERN-MEDICIS and shipping
Objective : to define the proper operational conditions and safety boundaries for the production and shipping of radioisotopes from radioactive ion beams
Expected Results: The CERN-MEDICIS facility is the first facility to start operation for the production of medical istope batches by mass separation. The necessary engineering validation and documentation steps will be elaborated for its safety file. This includes the procedure and design of isotope batch collection chambers, coupling of radiochemical purification modules to the isotope mass separator. The efficiencies for the collection of 149/152Terbium will be determined, and different engineering systems, such as targets and ion sources will be selected and optimized to achieve the best figures.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Cyclotron production and mass-separation of 47/48/49Sc
Large scale production of a beta-/gamma emitter radioisotope for therapy using a middle sized high-current cyclotron and the CERN-MEDICIS mass separation system
Objectives: feasibility study for a large scale production of selected isotopes using a middle sized high current cyclotron and the CERN-MEDICIS mass separation system
Expected Results: Perform a explorative study based on theoretical analysis and Monte Carlo simulations in order to identify radioisotopes with favourable characteristics, namely: β- spectrum for therapy; γ emission for SPECT imaging; half-life for logistics and clinical use, corresponding β+ (positron) emitting isotope to be used as companion diagnostic agent; favourable chemistry for targeted radiometabolic therapy suitability; effective production yield, for 30-70 MeV protons, target feasibility, effective extraction yield with the CERN-MEDICIS mass separation system.)
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Remote laser ion source operation system for installation at medical cyclotrons
Remotely operated Laser Ion Source for radiolanthanide purification at medical cyclotrons
Objectives: efficient mono-isobaric ion beam production via elemental selective laser ionization
Expected Results: Each chemical element needs a defined 2 or 3 –steps laser ionization scheme. Terbium, Lutetium and Erbium isotopes will first be considered, using solid-state diode lasers that are better suited for remote operation. The ion source cavity (length, material, temperature) at the mass separator will afterward be developed to increase the ionization efficiencies. Finally a fully automated control software and monitoring will be implemented fo foresee its transfer at a medical cyclotron.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Laser molecular break-up in RFQ cooler for beam purification
Molecular break-up by laser in RFQ cooler
Objective : To study the impact of the chemical nature of the molecules on their break up in a RFQ-Cooler device before or after mass separation of molecular isotope beams
Expected Results: A :Different types of molecular ions will be injected in a RFQ Cooler, such as LnF+, CO+, CH4+. B The efficiencies of transmission, time of residence will be investigated by varying the cooling gas pressure, its nature (He, H2, H2O). C The molecular break-up by UV laser light excitation will be investigated. The precise required repetition rate, wavelength, plasma induction will be investigated. D The presence of other beam components on the results, such as alkali metals, will be investigated, to decide if the purification step must take place before or after mass-separation.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Personnalized 11C PET aided hadron therapy
Personalized 11Carbon PET aided hadron therapy
Objective: to adapt the treatment plan according to PET response halfway through the course of hadron therapy, to investigate hypoxia tracers, fluorinated aminoacides or DNA synthesis markers and to validate PET for early response assessment.
Expected Results: select most suitable PET tracers for adaptive hadron therapy and early response evaluation. New tracers will be investigated including hypoxia tracer (a non exhaustive list is: 18F-MISO, 18F-FAZA, 62Cu-ATSM) other fluorinated aminoacids (18F-FET, 18F-FACBC, etc.) or DNA synthesis markers (18- fluorothymidine). The tools developed for FLUKA will be verified at CNAO in a clinical scenario. Comparisons with the standard 12C treatment plans will be studied in terms of dose, biological effect and ß+-emitters distributions
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
New robot-assisted instruments and delivery methods for brachytherapy
Technical leader: partner organization UNIGE (CH)
New robot-assisted instruments and delivery methods for brachytherapy
Objective: Develop and validate new delivery techniques for brachytherapy in computerized and large animal models
Expected Results: The aim of this project is to establish new instruments and delivery methods for brachytherapy using stereotactic, endoscopic ultrasonographic-guided or robotic-assisted surgery for the treatment of non-resectable brain, ovarian and pancreatic cancers. New isotopes with specific types of emission, tissue penetration and half-life will be developed at CERN-MEDICIS. For brain tumors, we will use stereotactic and/or image-guided placement of coated particles, based on magnetic resonance imaging. For ovarian and pancreatic cancers, we will evaluate endoscopic ultrasonographic guided delivery of seeds and will establish the Da Vinci robot-assisted system for intra-organ placement of seeds.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-23 |
Website
Creation of project website for internal and external use.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Websites, patent fillings, videos etc. |
2019-07-10 |
Public lecture
Public lecture on advancements in the field of radioisotopes and medical treatment.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Other |
2019-07-10 |
Enrolment in PhD program
Enrolment of the ESRs in PhD programs
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Other |
2019-07-10 |
Investigation of imaging probes for ovarian cancer in animal models
Technical leader: partner organization UNIGE (CH)
Investigation of bimodal imaging probes for ovarian cancer in animal models
Objective: Develop and validate preclinical imaging techniques for assessment of bio-distribution and performance of new tracers in animal models for prediction of therapeutic efficacy of new radio-labelled compounds at Institute of Translational Molecular Imaging (ITMI)
Expected Results: Development of methodology and validation of preclinical techniques. The ESR will be responsible of seeking new methodological techniques and experimental protocols that are suitable for the new compounds that are being evaluated. It will also include the development and validation of biological models that allow quantitative assessment of the efficacy and performance of the tracers as well as their potential efficacy of treatment of the given tumours.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-10 |
Design of new containers for theranostic isotope pairs transportation
New shielded packaging container for nuclear medicine isotopes
Objective: To obtain a new technology type B certified shipping container.
Expected Results: The typical isotopes (149,152,155,161Tb, 177Lu, 47,48,49Sc, etc) and activities for shipment will first be defined. The European shipping regulations will then be studied in details. First dimensioning of the required shielding, mechanical resistance with be done by Monte-Carlo simulations and by Finite Element Model Mechanical codes. A first prototype will be constructed and checked for effective shielding capacity, leak tightness, shock resistance, etc. A second packaging will be constructed, learning from the prototype, and documentation will be filed to obtain its homologation. Specific innovations, such as direct transfer of the collected isotopes from the separator into the packaging are foreseen.
Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2014-ETN
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Documents, reports |
2019-07-10 |
