FibreRemodel SIGNED
Frontier research in arterial fibre remodelling for vascular disease diagnosis and tissue engineering
Total Cost €
0EC-Contrib. €
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Project "FibreRemodel" data sheet
The following table provides information about the project.
| Coordinator |
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 1˙521˙875 € |
| EC max contribution | 1˙521˙875 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN | IE (DUBLIN) | coordinator | 1˙521˙875.00 |
Map
Project objective
Each year cardiovascular diseases such as atherosclerosis and aneurysms cause 48% of all deaths in Europe. Arteries may be regarded as fibre-reinforced materials, with the stiffer collagen fibres present in the arterial wall bearing most of the load during pressurisation. Degenerative vascular diseases such as atherosclerosis and aneurysms alter the macroscopic mechanical properties of arterial tissue and therefore change the arterial wall composition and the quality and orientation of the underlying fibrous architecture. Information on the complex fibre architecture of arterial tissues is therefore at the core of understanding the aetiology of vascular diseases. The current proposal aims to use a combination of in vivo Diffusion Tensor Magnetic Resonance Imaging, with parallel in silico modelling, to non-invasively identify differences in the fibre architecture of human carotid arteries which can be directly linked with carotid artery disease and hence used to diagnose vulnerable plaque rupture risk. Knowledge of arterial fibre patterns, and how these fibres alter in response to their mechanical environment, also provides a means of understanding remodelling of tissue engineered vessels. Therefore, in the second phase of this project, this novel imaging framework will be used to determine fibre patterns of decellularised arterial constructs in vitro with a view to directing mesenchymal stem cell growth and differentiation and creating a biologically and mechanically compatible tissue engineered vessel. In silico mechanobiological models will also be used to help identify the optimum loading environment for the vessels to encourage cell repopulation but prevent excessive intimal hyperplasia. This combination of novel in vivo, in vitro and in silico work has the potential to revolutionise approaches to early diagnosis of vascular diseases and vascular tissue engineering strategies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Shahid, S.S., Kerskens, C., Gaul, R. Flamini, V., Lally, C. Ex-vivo arterial collagen fibre tractography using micro-diffusion tensor imaging published pages: , ISSN: , DOI: |
Proceedings of the European Society for Magnetic Resonance in Medicine and Biology, September 29-October 1, Vienna, Austria. September 2016 (yearly) | 2019-11-22 |
| 2016 |
Lally C., Dunphy, S., Mathieu, P., Nolan, D., Cahill, P. Understanding the critical role of strain and structure in vascular remodelling, regeneration and disease. published pages: , ISSN: , DOI: |
Matrix Biology Ireland Abstract Proceedings November 2016 (Yearly) | 2019-11-22 |
| 2017 |
Nolan, D.R., Ghasemi, M, Lally, C Assessment of clinically relevant measure for identifying vulnerable carotid plaque published pages: , ISSN: , DOI: |
Bioengineering in Ireland 23 Conference January 2017 (yearly) | 2019-11-22 |
| 2017 |
CaitrÃona Lally, Syed S. Shahid, Christian Kerskens, Céline Smekens, Robert Johnston, Non-Destructive Characterisation of Arterial Structure using High-Resolution Diffusion MRI published pages: , ISSN: , DOI: |
Proceedings of the Matrix Biology Ireland Conference 2017 Yearly | 2019-11-22 |
| 2018 |
Gaul, R T; Nolan, D R; Ristori, T; Loerakker, S; Lally, C. STRAIN MEDIATED ARTERIAL DEGRADATION IS CRITICALLYINFLUENCED BY MATRIX CONTENT AND COLLAGEN CRIMP published pages: , ISSN: , DOI: |
24th Bioengineering in Ireland Conference yearly | 2019-11-22 |
| 2018 |
Mathieu, P.S., Fitzpatrick, E., Cahill, P.A., Lally, C. VASCULAR SMOOTH MUSCLE CELLS AND MULTIPOTENT VASCULAR STEM CELLS DIFFER IN THEIR RESPONSE TO CYCLIC TENSILE STRAIN published pages: , ISSN: , DOI: |
Proceedings of World Congress of Biomechanics 2018 Every 4 years | 2019-11-22 |
| 2018 |
Ghasemi, M; Nolan, D R; Lally, C. DAMAGE ACCUMULATION IN ARTERIAL TISSUE; EXPERIMENTALOBSERVATIONS ON THE ROLE OF MATRIX AND FIBRES ANDCONSTITUTIVE MODEL DEVELOPMENT published pages: , ISSN: , DOI: |
24th Bioengineering in Ireland Conference Yearly | 2019-11-22 |
| 2018 |
Robert Johnston, David Nolan, Dorian Botella-Barriot, Milad Ghasemi, Christian Kerskens, Caitriona Lally Optimization of Magnetic Resonance Imaging (MRI) based Patient Specific Models with mechanical property estimation from inverse finite element analysis published pages: , ISSN: , DOI: |
Proceedings of the European Mechanics of Materials Conference Yearly | 2019-11-22 |
| 2017 |
Shahid, S.S., Kerskens, C., Gaul, R., Lally, C Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging published pages: , ISSN: , DOI: |
Proceedings of the European Molecular Imaging Meeting April 5-7, Cologne, Germany April 2016 (yearly) | 2019-11-22 |
| 2018 |
Gaul, R.T., Nolan, D.R., Ristori, T., Loerakker S., Lally, C. Degradation of arterial collagen with applied strain: critical influence of matrix content and collagen crimp published pages: , ISSN: , DOI: |
Proceedings of the World Congress of Biomechanics Every 4 years | 2019-11-22 |
| 2017 |
Ghasemi, M., Nolan, D.R., Lally, C Collagen fibre remodelling in arterial soft tissue published pages: , ISSN: , DOI: |
Bioengineering in Ireland 23 Conference January 2017 (yearly) | 2019-11-22 |
| 2018 |
Johnston, R., Nolan, D., Ghasemi, M., Kerskens, C., Lally, C. OPTIMIZATED PATIENT SPECIFIC FINITE ELEMENT MODELS AT THE CAROTID BIFURCATION published pages: , ISSN: , DOI: |
Proceedings of the World Congress of Biomechanics 2018 Every 4 years | 2019-11-22 |
| 2018 |
Smekens, C J; Shahid, S S; Kerskens, C; Lally C. PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE published pages: , ISSN: , DOI: |
24th Bioengineering in Ireland Conference Yearly | 2019-11-22 |
| 2018 |
Johnston, R; Nolan, D; Ghasemi, M; Kerskens, C; Lally, C. AN IN-VIVO STUDY ON THE IMPACT OF AXIAL RESOLUTION ONPEAK STRESSES AT THE CAROTID BIFURCATION published pages: , ISSN: , DOI: |
24th Bioengineering in Ireland Conference Yearly | 2019-11-22 |
| 2016 |
Ghasemi, M., Nolan, D.R., Lally, C A review of arterial tissue remodelling published pages: , ISSN: , DOI: |
Bioengineering in Ireland 22 Conference January 2016 (yearly) | 2019-11-22 |
| 2017 |
Syed Salman Shahid, Robert Gaul, Christian M Kerskens, Vittoria Flamini, Caitriona Lally Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging – comparison of intact vs. open cut tissue published pages: , ISSN: 0031-9155, DOI: 10.1088/1361-6560/aa9159 |
Physics in Medicine and Biology | 2019-11-22 |
| 2018 |
Ghasemi,M., Nolan, D., Lally, C. A constituent specific study of damage accumulation in arterial tissue published pages: , ISSN: , DOI: |
Proceedings of the World Congress of Biomechanics 2018 Every 4 years | 2019-11-22 |
| 2017 |
Shahid, S.S., Kerskens, C., Lally, C. Use of high-resolution micro-diffusion tensor imaging to estimate the ultra-structure of the arterial wall published pages: , ISSN: , DOI: |
Bioengineering in Ireland 23 Conference January 2017 (yearly) | 2019-11-22 |
| 2018 |
Ghasemi, M, Nolan, D, Lally, C. Exploring the influence of damage accumulation on collagen fibre remodelling in arteries under supra-physiological loads published pages: , ISSN: , DOI: |
Proceedings of the European Mechanics of Materials Conference Yearly | 2019-11-22 |
| 2018 |
Smekens, C. J.1,2, Shahid, S. S.3, Kerskens, C.4, Lally, C1,2 PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE published pages: , ISSN: , DOI: |
Proceedings of the World Congress of Biomechanics Every 4 years | 2019-11-22 |
| 2017 |
R.T. Gaul, D.R. Nolan, C. Lally Collagen fibre characterisation in arterial tissue under load using SALS published pages: 359-368, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2017.07.036 |
Journal of the Mechanical Behavior of Biomedical Materials 75 | 2019-11-22 |
| 2017 |
Robert Gaul, CaitrÃona Lally Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design published pages: , ISSN: , DOI: |
Summer Biomechanics, Bioengineering and Biotransport Conference | 2019-11-22 |
| 2018 |
R.T. Gaul, D.R. Nolan, T. Ristori, C.V.C. Bouten, S. Loerakker, C. Lally Strain mediated enzymatic degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp published pages: 301-310, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.06.037 |
Acta Biomaterialia 77 | 2019-11-22 |
| 2018 |
C. Lally, D.R. Nolan, P.S. Mathieu, A. McMahon, P.A. Cahill, E. Fitzpatrick Changes in the collagen fibre architecture within stented arterial tissue may play a critical role in directing the vascular cell response post stenting published pages: , ISSN: , DOI: |
Every four years | 2019-11-22 |
| 2018 |
R.T. Gaul, D.R. Nolan, C. Lally The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo published pages: , ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2018.10.006 |
Journal of Biomechanics | 2019-11-22 |
| 2018 |
Milad Ghasemi, David R. Nolan, CaitrÃona Lally An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development published pages: , ISSN: 1617-7959, DOI: 10.1007/s10237-018-1054-3 |
Biomechanics and Modeling in Mechanobiology | 2019-11-22 |
| 2017 |
Milad Ghasemi, David.R.Nolan, CaitrÃona Lally TOWARD THE DEVELOPMENT OF A CONSTITUTIVE MODEL TOCAPTURE ARTERIAL COLLAGEN FIBRE REMODELLING AND DAMAGE published pages: , ISSN: , DOI: |
Proceedings of the European Society of Biomechanics Congress July 2017 | 2019-11-22 |
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