Report
Teaser, summary, work performed and final results
Periodic Reporting for period 2 - HIRESMEMMANIP (Spiking network mechanisms underlying short term memory)
Teaser
The main goal in this project is to determine the neuronal codes underlying STM per se.
Summary
The main goal in this project is to determine the neuronal codes underlying STM per se.
Work performed
During the first 30 months of the action, efforts have been focused on behavioral, computational, engineering, and theoretical infrastructure. In the context of animal behavior: we identified novel constraints on behavioral paradigms; invented three new tasks that cannot be solved without STM; and developed a hybrid mouse strain with enhanced sensory and cognitive abilities. In the context of determining the contribution of spike timing to memory behavior: we developed a mathematical framework according to which spike timing should be manipulated, and innovated two types of implantable dual-color optical devices for independent multi-site control of neuronal activity. In the context of determining codes sufficient for STM: we designed and fabricated a novel multi-channel stimulation chip in CMOS and an on-head signal processing system, and developed an apparatus and paradigm for teaching an animal to associate arbitrary neuronal patterns with behavioral choices.
Final results
In the second period of the action, we will use this infrastructure for determining the necessary and sufficient codes for STM.