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MESOTAS-SIEVE SIGNED

Sieving neuronal network communication

Total Cost €

EC-Contrib. €

Partnership

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MESOTAS-SIEVE project word cloud

Explore the words cloud of the MESOTAS-SIEVE project. It provides you a very rough idea of what is the project "MESOTAS-SIEVE" about.

mesotas place integrate shape solid initial model vitro viability cell market plan first days contact natural business gt platform basis human starting discoveries chip mea grant erc electrodes intellectual microculture realisation culturing ip efficacy drug poc optimal 2016 toxicity bioreactor assays data attract array mimic provides models physiologically performed financing culture single 3d functional 2011 uniquely micro networks microelectrode competitor capacity network forms readout protection property line function connection commercial sieve industry commercialization neuronal animal brain tissue survives conventional

Project "MESOTAS-SIEVE" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2018-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	coordinator	150˙000.00

Map

Project objective

This project will demonstrate the technical and commercial viability of the MESOTAS-SIEVE bioreactor, a novel 3D brain-on-chip microculture system. This allows the culturing and in vitro functional analysis of neuronal networks that mimic the human brain in a physiologically much more relevant way than conventional cell culture systems or animal models. Therefore, the MESOTAS-SIEVE system has great potential towards the realisation of tissue models of the brain for drug efficacy and toxicity assays. This project is based on exciting discoveries done in the ERC Starting Grant project MESOTAS (2011-2016). In MESOTAS, a bioreactor on a microelectrode array (MEA) has been developed to study the ‘natural’ behaviour of 3D neuronal networks. For this bioreactor, a neuronal cell line has been identified that uniquely survives >30 days and forms neuronal networks. To further improve function and network formation capacity, this project will integrate a micro-sieve at the bottom of the MESOTAS bioreactor to improve cell shape, function and optimal connection to the MEA electrodes for single-cell readout of activity. PoC of this MESOTAS-SIEVE bioreactor provides the basis for further development towards a commercial brain-on-a-chip platform. The first steps towards commercialization of MESOTAS-SIEVE will be performed as part of this project and initial industry contact are already in place. During the project we will establish a solid business model, including intellectual property (IP) protection, a market/competitor analysis, and an exploitation plan. Towards the end of this project the “data package” will be used to attract further financing towards commercialization.

Publications

List of publications.
year	authors and title	journal	last update
2018	Linda H.M. van de Burgwal, Pim van Dorst, Henk ViÃ«tor, Regina Luttge, Eric Claassen Hybrid business models for â€˜Organ-on-a-Chipâ€™ technology: The best of both worlds published pages: 55-63, ISSN: 2213-4344, DOI: 10.1016/j.phanu.2018.02.001	PharmaNutrition 6/2	2019-06-13
2017	Jean-Philippe Frimat, Bart Schurink, Regina Luttge Passive pumping for the parallel trapping of single neurons onto a microsieve electrode array published pages: 06GA01, ISSN: 2166-2754, DOI: 10.1116/1.4991827	Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena 35/6	2019-06-13
2018	Emma Moonen, Regina Luttge, Jean-Philippe Frimat Single cell trapping by capillary pumping using NOA81 replica moulded stencils published pages: , ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.04.010	Microelectronic Engineering	2019-06-13

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