Explore the words cloud of the TRAIN project. It provides you a very rough idea of what is the project "TRAIN" about.
The following table provides information about the project.
Coordinator |
THE UNIVERSITY OF SHEFFIELD
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://train-itn.eu |
Total cost | 3˙818˙970 € |
EC max contribution | 3˙818˙970 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2016 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2016 |
Duration (year-month-day) | from 2016-09-01 to 2020-08-31 |
Take a look of project's partnership.
This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects described in the proposal will investigate regulators of these pathways with a focus on a recently described family of pseudokinases, namely tribbles proteins, which have a key role in controlling immunity, metabolism and cancer, and which here will serve as prototypical examples for integrative metabolocentric cancer research. Tribbles are envisaged to contribute directly to the development and progression of prostate cancer, the prognosis of which is substantially worsened in individuals with immuno-metabolic disease. We therefore propose a multidisciplinary research-training programme with an overall objective to uncover cell-specific aspects of tribbles-mediated control of immuno-metabolism and their impact on prostate cancer progression. We will approach this by integrating cell biology and sophisticated in vivo models of both immuno-metabolic disease and prostate cancer, complemented by specialist human disease biobanks, cutting-edge genomics approaches, plus a drug discovery pipeline. This will be carried out by an alliance of leading academic research groups and specialist SMEs with complementary backgrounds in inflammation, adipose tissue biology, tumourigenesis, genomics, translational models of human disease, medicinal chemistry and drug discovery. This will provide a unique opportunity for a cohort of PhD students to undertake Research Training at the interface of several disciplines and sectors, thereby gaining a diverse portfolio of R&D expertise and transferrable skills as well as exposure to several non-academic career pathways.
8.1 | Documents, reports | 2019-08-20 18:04:14 |
7.1 | Websites, patent fillings, videos etc. | 2019-08-20 18:04:14 |
8.3 | Documents, reports | 2019-08-20 18:04:14 |
8.2 | Websites, patent fillings, videos etc. | 2019-08-20 18:04:14 |
5.2 | Documents, reports | 2019-08-20 18:04:14 |
Take a look to the deliverables list in detail: detailed list of TRAIN deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Chiara Niespolo, Juan Salamanca Viloria, Oscar Villacanas Perez, Heather Wilson, Endre Kiss-Toth Post-transcriptional regulation of trib1 by mirnas in primary macrophages published pages: , ISSN: , DOI: 10.1136/heartjnl-2018-BCS.109 |
Heart Volume 104, Issue Supp 6 | 2019-08-20 |
2018 |
Laura Martinez Campesino, Jessica Johnston, Endre Kiss-Toth, Heather Wilson TRIB3-mediated regulationof macrophage phenotype published pages: , ISSN: , DOI: 10.1136/heartjnl-2018-BCS.113 |
Heart Vol 104, Issue Suppl 6 | 2019-08-20 |
2017 |
Jack P Green, Celine Souilhol, Ioannis Xanthis, Laura Martinez-Campesino, Neil P Bowden, Paul C Evans, Heather L Wilson Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling published pages: 324-335, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx213 |
Cardiovascular Research 114/2 | 2019-08-20 |
2018 |
Jessica M Johnston, Sheila E Francis, Endre Kiss-Toth Experimental models of murine atherosclerosis: does perception match reality? published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvy140 |
Cardiovascular Research | 2019-08-20 |
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The information about "TRAIN" are provided by the European Opendata Portal: CORDIS opendata.