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ROPHARE SIGNED

Insights into the role of phages on the bacterial resistome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ROPHARE project word cloud

Explore the words cloud of the ROPHARE project. It provides you a very rough idea of what is the project "ROPHARE" about.

natural acquired genomics antibiotic contact genetics interactions combines antimicrobial bacteriophages possess bacteria skills molecular biomes clinical genes biology evolution understand there ancient followed vitro abundant drive researcher tools microbial bottlenecks ecological imperative multidisciplinary entities holistic transduction occurring animal phage transferring genomic connectivity amr hence shows experimental computational naturally veterinary attractive competitive metagenomics human profile excellence selective phages centres ecosystems environmental spread indirect antibiotics bioinformatics environments transmission quality earth specialist gain pressure evading additional training agriculture resistance vehicles anthropogenic critical meta modulates

Project "ROPHARE" data sheet

The following table provides information about the project.

Coordinator	FUNDACION RIOJA SALUD-FRS Organization address address: CALLE PIQUERAS 98 city: LOGRONO postcode: 26006 website: www.riojasalud.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.foodmicrobiology.ethz.ch/en/research.html
Total cost	254˙480 €
EC max contribution	254˙480 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-GF
Starting year	2016
Duration (year-month-day)	from 2016-12-26 to 2019-12-25

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACION RIOJA SALUD-FRS FUNDACION RIOJA SALUD-FRS Organization address address: CALLE PIQUERAS 98 city: LOGRONO postcode: 26006 website: www.riojasalud.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LOGRONO)	coordinator	254˙480.00
2	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	partner	0.00

Map

Project objective

There is an imperative need to gain knowledge on the spread and evolution of antimicrobial resistance (AMR). Recent evidence from environmental, animal and human microbial studies shows that AMR is ancient and environments without contact with anthropogenic antibiotics possess abundant AMR genes. Bacteriophages are the most abundant entities in Earth and recent studies provide indirect evidence for the major role of transduction in the dissemination of AMR genes. Hence, phages might be of critical importance for evading one of the bottlenecks (ecological connectivity) that modulates the transmission of AMR genes from natural environments to animal and human biomes. In this proposal, a holistic and multidisciplinary approach that combines molecular genetics, genomics, metagenomics, in-vitro experimental analysis, computational biology, bioinformatics analysis, and modelling will be followed to measure the potential of naturally occurring phages to be vehicles for AMR transmission and spread in environmental systems with different antibiotic selective pressure. This comprehensive approach will allow us to better understand the phage-bacteria interactions that drive the AMR spread in different ecosystems. From this understanding we expect to be able to design and develop new tools for the control of antimicrobial resistance in clinical and veterinary practice as well as in agriculture. This project will contribute to the objectives of the Work Programme by: 1) allowing the researcher to gain new skills and additional training-through-research in phage and phage-bacteria interactions, computational and (meta)genomic analysis; and to become an EU leading specialist in a research field with emerging growth potential; 2) transferring the acquired knowledge to the EU; 3) establish a long-term collaboration between several centres of excellence that will enhance the quality of research of Europe and make it more competitive and attractive for high-profile researchers.

Publications

List of publications.
year	authors and title	journal	last update
2020	Pauline C. GÃ¶ller, Jose M. Haro-Moreno, Francisco Rodriguez-Valera, Martin J. Loessner, Elena GÃ³mez-Sanz Uncovering a hidden diversity: optimized protocols for the extraction of dsDNA bacteriophages from soil published pages: , ISSN: 2049-2618, DOI: 10.1186/s40168-020-0795-2	Microbiome 8/1	2020-02-27
2019	Elena GÃ³mez-Sanz, Sara Ceballos, Laura Ruiz-Ripa, Myriam Zarazaga, Carmen Torres Clonally Diverse Methicillin and Multidrug Resistant Coagulase Negative Staphylococci Are Ubiquitous and Pose Transfer Ability Between Pets and Their Owners published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00485	Frontiers in Microbiology 10	2020-02-27

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The information about "ROPHARE" are provided by the European Opendata Portal: CORDIS opendata.