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Report

Teaser, summary, work performed and final results

Periodic Reporting for period 1 - CARBOMET (Metrology of Carbohydrates for Enabling European Bioindustries)

Teaser

Summary

CarboMet will foster and drive collaboration, cross-fertilisation and communication among stakeholders to facilitate a uniform approach to the metrology and/or measurement of carbohydrates for exploitation in biopharmaceuticals, diagnosis of disease and precision medicine, food and personal care and sustainable material BioIndustries. This will be achieved through a consolidated approach towards the modification of key emerging technologies or identification of radically new technologies currently unforeseen by technology roadmaps. CarboMet will use a range of communication and dissemination tools (meetings, workshops, website, surveys, briefing papers) to engage key stakeholders, to establish the current emerging technologies, limitations, and barriers to implementation. Priority areas, future challenges and a wish list of capabilities will then be defined, culminating in the production of a roadmap for 2030, setting out a Europe-wide vision. These capabilities will lead to new robust metrologies for the exploitation of carbohydrates.

Work performed

In the reporting period CarboMet has held 3 scoping workshops, organised by BioIndustry Sector namely in the topics of Carbohydrate based vaccines; Carbohydrates in the microbiome; & Glycomaterials. These workshops brought key players from industry giving an industrial focus as well as providing a forum for the CarboMet community to network and engage with industry. Another vital activity in the period has been updating the website, to fulfil the associated deliverables and to address feedback from the year 1 review where it was noted that the website is a key dissemination strategy which should be completed in order to reach the targeted stakeholders and end users more effectively. This was achieved using feedback from workshops and an online survey designed specifically for that purpose i.e. to gain input from the glycoscience community to fill knowledge gaps. Efforts towards improving the website architecture to allow ease of finding expertise as advised by the project reviewers are ongoing and will be fulfilled as outputs from activities in year 3. 2 positioning papers on â€˜Targeting Antimicrobial Resistance with Carbohydrate-Based Vaccinesâ€™ and â€˜The Essential Roles of Carbohydrates in Promoting Gut Microbiota Function Through All Stages of Lifeâ€™ (and a 3rd which is currently being written on glycomaterials) have been produced which have proved important in a number of ways, above and beyond records of workshop discussions. They have proved important documents for the community to input to parallel activities such as writing funding proposals as well as being important materials for informing policy discussions and meetings. CarboMet has so far identified three areas where metrology will be important: 1. Development of carbohydrate-based vaccines, which includes strong components of diagnostic tools; 2. The role of carbohydrates in the microbiome; and, 3. Glycomaterials. A portfolio of case studies to highlight achievements in bringing carbohydrate based innovations to market and the metrological challenges that had to be overcome in order to do so. These cover a number of high value areas including biopharmaceuticals (7 of the top ten selling drugs are biologics), and human milk oligosaccharides: The infant formula ingredients market was valued at $13.99 bn in 2016 and is projected to reach around $23.79 bn by 2022. As we reach the mid point of the project and finalise the information gathering period, these positioning papers and case studies provide an important platform going into the second phase of the project. The challenges identified during the information gathering stage will now be communicated and disseminated to decision makers, policy makers, funding bodies, regulatory bodies in stage 2 of the project. Part of this work includes holding training workshops in each Enabling Technology Area as a means to highlight the current state of the art in carbohydrate metrology and engage with early stage researchers and scientists outside the glycoscience community. One of these workshops has already taken place. The successful Glycoinformatics Masterclass held in Lisbon, July 2018 had a high level of engagement (over 100 participants including ~65 Early Career Researchers). In summary, work has been completed during the period to complete the first stage of the project which has focused on engaging with the stakeholders and key players and preparing materials for the second stage of the project. By obtaining input from diverse elements of the glycoscience community together and formulating common goals, representatives from CarboMet can confidently act as a focal point on behalf of the community to engage decision makers, policy makers, funding and regulatory bodies.

Final results

Objective 1 Establish a European Glycoscience User Group, a large group of experts drawn from all relevant disciplines and sectors that facilitates the exchange of non-competitive metrological know how between stakeholders. CarboMet has brought together a group of experts from a number of academic institutions as well as industry representatives from the 4 BioIndustry Sectors, policy makers and economists, including the following companies: BASF, Bio-Shape, Covance, Dextra, DSM, Elicityl, Fermentalg, Friesland Campina, Glycomix, GlycoSeLect, GSK, Inbiose, Intellihep, LGC, Ludger, MedImmune, Nestec, Polymaris Technology, Prozomix, Sanofi, TdB Consultancy, UCB, Unilever, Waters.
Objective 2 Identify Common Scientific and Technical Challenges in each of the 4 BioIndustry Sectors using as tools the 3 Enabling Technology Areas and assess their relevance of these challenges to the other BIS. CarboMet has identified a number of common strategic scientific and industrial challenges. These challenges identified through CarboMet workshop discussions have been captured in 2 positioning papers on â€˜Targeting Antimicrobial Resistance with Carbohydrate-Based Vaccinesâ€™ and â€˜The Essential Roles of Carbohydrates in Promoting Gut Microbiota Function Through All Stages of Lifeâ€™. A third positioning paper is currently being written on glycomaterials.
Objective 3 Establish a Common Vision, Roadmap for 2030 and an Associated Implementation Plan â€“ to enable European Bioindustries to achieve global leadership for the delivery of standardised carbohydrate and glycoconjugate metrology methods.
A fully validated strategic roadmap and implementation plan will be created and published by year 4/2020. Validation will be achieved by having input from all CarboMet stakeholders and a dedicated scoping workshop will be held to formulate an initial draft roadmap, in late 2019.
Objective 4 Through Knowledge Exchange Activities Facilitate the Formation of a Cross- Sectorial Glycoscience Metrology Platform â€“ CarboMet will draw on the actions and activities described in Obj. 2 & 3 to create a Knowledge Platform on Glycoscience priorities and challenge areas. These will be captured in a series of briefing papers that will form a basis for the European National Measurement Institutes (NMI) to construct a future set of priorities and a possible program on metrology needs for carbohydrates and glycoconjugates under EMPIR.