TRoMBONE
Therapy for regeneration of Heart Muscle based on targeted delivery of exosomes
Total Cost €
0EC-Contrib. €
0Partnership
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0TRoMBONE project word cloud
Explore the words cloud of the TRoMBONE project. It provides you a very rough idea of what is the project "TRoMBONE" about.
Project "TRoMBONE" data sheet
The following table provides information about the project.
| Coordinator |
CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Project website | https://explore.openaire.eu/search/project |
| Total cost | 160˙635 € |
| EC max contribution | 160˙635 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-04-01 to 2019-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO | PT (COIMBRA) | coordinator | 160˙635.00 |
Map
Project objective
Given the poor regenerative potential of the adult heart after heart failure (HF), therapies capable of contributing for cardioprotection and cardio-regeneration are of great need. Recent advances in pharmacologic therapy and stem cells are currently not enough to address HF. The hypothesis of this project is that exosomes, nanovesicles secreted by cells may be a potential therapy for HF. Exosomes may offer advantages relatively to cell-based therapies regarding efficacy (does not require engraftment and survival), processing and cost. The main objective of the current project is to develop an effective strategy to deliver exosomes by intravenous (IV) injection into the heart (targeting) and to maximize exosome regenerative potential (bioactivity). Therefore, the project aims to develop a non-cellular-based therapy to regenerate the heart after infarction based on the targeted delivery of exosomes. Undertaking this research along with formal training and mentoring will enhance my academic profile, scientific experience, and content expertise in nanobiotechnology, to enable me to develop into an independent, leading researcher. The proposed research contributes to the EU priority of addressing the societal challenge of improving lifelong health and wellbeing of all.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Arnab Banerjee, Vitor Alves, Tiago Rondão, José Sereno, Ângela Neves, Miguel Lino, Andreia Ribeiro, Antero J. Abrunhosa, Lino S. Ferreira A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles published pages: 13243-13248, ISSN: 2040-3364, DOI: 10.1039/c9nr02512j |
Nanoscale 11/28 | 2019-10-29 |
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The information about "TROMBONE" are provided by the European Opendata Portal: CORDIS opendata.